Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Mol Cell Biol
1999 Feb 01;192:1262-70. doi: 10.1128/MCB.19.2.1262.
Show Gene links
Show Anatomy links
A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development.
Nielsen J
,
Christiansen J
,
Lykke-Andersen J
,
Johnsen AH
,
Wewer UM
,
Nielsen FC
.
???displayArticle.abstract???
Insulin-like growth factor II (IGF-II) is a major fetal growth factor. The IGF-II gene generates multiple mRNAs with different 5' untranslated regions (5' UTRs) that are translated in a differential manner during development. We have identified a human family of three IGF-II mRNA-binding proteins (IMPs) that exhibit multiple attachments to the 5' UTR from the translationally regulated IGF-II leader 3 mRNA but are unable to bind to the 5' UTR from the constitutively translated IGF-II leader 4 mRNA. IMPs contain the unique combination of two RNA recognition motifs and four hnRNP K homology domains and are homologous to the Xenopus Vera and chicken zipcode-binding proteins. IMP localizes to subcytoplasmic domains in a growth-dependent and cell-specific manner and causes a dose-dependent translational repression of IGF-II leader 3 -luciferase mRNA. Mouse IMPs are produced in a burst at embryonic day 12.5 followed by a decline towards birth, and, similar to IGF-II, IMPs are especially expressed in developing epithelia, muscle, and placenta in both mouse and human embryos. The results imply that cytoplasmic 5' UTR-binding proteins control IGF-II biosynthesis during late mammalian development.
Allain,
Structural basis of the RNA-binding specificity of human U1A protein.
1997, Pubmed
Allain,
Structural basis of the RNA-binding specificity of human U1A protein.
1997,
Pubmed
Andersson,
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme.
1989,
Pubmed
Baker,
Role of insulin-like growth factors in embryonic and postnatal growth.
1993,
Pubmed
Brice,
Temporal changes in the expression of the insulin-like growth factor II gene associated with tissue maturation in the human fetus.
1989,
Pubmed
Chomczynski,
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
1987,
Pubmed
Davydova,
Overexpression in COS cells of p50, the major core protein associated with mRNA, results in translation inhibition.
1997,
Pubmed
De Boulle,
A point mutation in the FMR-1 gene associated with fragile X mental retardation.
1993,
Pubmed
DeChiara,
Parental imprinting of the mouse insulin-like growth factor II gene.
1991,
Pubmed
Delbridge,
A human candidate spermatogenesis gene, RBM1, is conserved and amplified on the marsupial Y chromosome.
1997,
Pubmed
Del Tito,
Effects of a minor isoleucyl tRNA on heterologous protein translation in Escherichia coli.
1995,
Pubmed
de Moor,
Proteins binding to the leader of the 6.0 kb mRNA of human insulin-like growth factor 2 influence translation.
1995,
Pubmed
Deshler,
A highly conserved RNA-binding protein for cytoplasmic mRNA localization in vertebrates.
1998,
Pubmed
,
Xenbase
Eggenschwiler,
Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes.
1997,
Pubmed
Ghetti,
hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs.
1992,
Pubmed
Havin,
RNA-binding protein conserved in both microtubule- and microfilament-based RNA localization.
1998,
Pubmed
,
Xenbase
Kim-Ha,
Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential.
1995,
Pubmed
Kislauskis,
Isoform-specific 3'-untranslated sequences sort alpha-cardiac and beta-cytoplasmic actin messenger RNAs to different cytoplasmic compartments.
1993,
Pubmed
Melton,
Translocation of a localized maternal mRNA to the vegetal pole of Xenopus oocytes.
,
Pubmed
,
Xenbase
Müeller-Pillasch,
Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein.
1997,
Pubmed
Musco,
The solution structure of the first KH domain of FMR1, the protein responsible for the fragile X syndrome.
1997,
Pubmed
Newell,
Discriminating translation of insulin-like growth factor-II (IGF-II) during mouse embryogenesis.
1994,
Pubmed
Nielsen,
Receptor binding, endocytosis, and mitogenesis of insulin-like growth factors I and II in fetal rat brain neurons.
1991,
Pubmed
Nielsen,
Translational discrimination of mRNAs coding for human insulin-like growth factor II.
1990,
Pubmed
Nielsen,
Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway.
1995,
Pubmed
Reijo,
Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene.
1995,
Pubmed
Ross,
Characterization of a beta-actin mRNA zipcode-binding protein.
1997,
Pubmed
Siomi,
RNA-binding proteins as regulators of gene expression.
1997,
Pubmed
Stylianopoulou,
Pattern of the insulin-like growth factor II gene expression during rat embryogenesis.
1988,
Pubmed
Sun,
Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome.
1997,
Pubmed
Sussenbach,
The gene structure of the insulin-like growth factor family.
1989,
Pubmed
Weksberg,
Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndrome.
1993,
Pubmed
Wewer,
Tetranectin is a novel marker for myogenesis during embryonic development, muscle regeneration, and muscle cell differentiation in vitro.
1998,
Pubmed
Wewer,
Extrasynaptic location of laminin beta 2 chain in developing and adult human skeletal muscle.
1997,
Pubmed
