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A method is presented for detecting the cellular location of specific DNA fractions. The technique involves the hybridization of a radioactive test DNA in solution to the stationary DNA of a cytological preparation. Sites of DNA binding are then detected by autoradiography. Experiments with DNA of the toad Xenopus are described.
Britten,
Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms.
1968, Pubmed
Britten,
Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms.
1968,
Pubmed
Brown,
Specific gene amplification in oocytes. Oocyte nuclei contain extrachromosomal replicas of the genes for ribosomal RNA.
1968,
Pubmed
CONGER,
A quick-freeze method for making smear slides permanent.
1953,
Pubmed
Corneo,
Isolation and characterization of mouse and guinea pig satellite deoxyribonucleic acids.
1968,
Pubmed
COWIE,
HOMOLOGY BETWEEN BACTERIOPHAGE LAMBDA DNA AND E. COLI DNA.
1963,
Pubmed
Evans,
Localization of amplified ribosomal DNA in the oocyte of Xenopus laevis.
1968,
Pubmed
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Xenbase
Flamm,
Some properties of the single strands isolated from the DNA of the nuclear satellite of the mouse (Mus musculus).
1969,
Pubmed
Gall,
The genes for ribosomal RNA during oögenesis.
1969,
Pubmed
Gall,
Differential synthesis of the genes for ribosomal RNA during amphibian oögenesis.
1968,
Pubmed
Gall,
Formation and detection of RNA-DNA hybrid molecules in cytological preparations.
1969,
Pubmed
,
Xenbase
HYER,
A MOLECULAR APPROACH IN THE SYSTEMATICS OF HIGHER ORGANISMS. DNA INTERACTIONS PROVIDE A BASIS FOR DETECTING COMMON POLYNUCLEOTIDE SEQUENCES AMONG DIVERSE ORGANISMS.
1964,
Pubmed
John,
RNA-DNA hybrids at the cytological level.
1969,
Pubmed
KIT,
Equilibrium sedimentation in density gradients of DNA preparations from animal tissues.
1961,
Pubmed
MCCARTHY,
An approach to the measurement of genetic relatedness among organisms.
1963,
Pubmed
SCHILDKRAUT,
The formation of hybrid DNA molecules and their use in studies of DNA homologies.
1961,
Pubmed
Wallace,
Ribosomal cistrons and the nucleolar organizer.
1966,
Pubmed
Westmoreland,
Mapping of deletions and substitutions in heteroduplex DNA molecules of bacteriophage lambda by electron microscopy.
1969,
Pubmed
