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XB-ART-8008
FEBS Lett 2001 Nov 30;5091:126-30. doi: 10.1016/s0014-5793(01)03151-9.
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BMP signaling regulates Nkx2-5 activity during cardiomyogenesis.

Jamali M , Karamboulas C , Rogerson PJ , Skerjanc IS .


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Nkx2-5 regulates the transcription of muscle-specific genes during cardiomyogenesis. Nkx2-5 expression can induce cardiomyogenesis in aggregated P19 cells but not in monolayer cultures. In order to investigate the mechanism by which cellular aggregation regulates Nkx2-5 function, we examined the role of bone morphogenetic protein 4 (BMP4). We showed that the expression of the BMP inhibitor, noggin, was sufficient to inhibit the induction of cardiomyogenesis by Nkx2-5 during cellular aggregation. Furthermore, soluble BMP4 could activate Nkx2-5 function in monolayer cultures, resulting in the formation of cardiomyocytes. Therefore, BMP signaling is necessary and sufficient for the regulation of Nkx2-5 activity during cardiomyogenesis in P19 cells.

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Species referenced: Xenopus
Genes referenced: bmp4 nkx2-5 nog