Curr Opin Neurobiol 2016 Dec 01;41:17-23. doi: 10.1016/j.conb.2016.07.002.

Early development and function of the Xenopus tadpole retinotectal circuit.

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The retinotectal circuit is the major component of the amphibian visual system. It is comprised of the retinal ganglion cells (RGCs) in the eye, which project their axons to the optic tectum and form synapses onto postsynaptic tectal neurons. The retinotectal circuit is relatively simple, and develops quickly: Xenopus tadpoles begin displaying retinotectal-dependent visual avoidance behaviors by approximately 7-8 days post-fertilization, early larval stage. In this review we first provide a summary of the dynamic development of the retinotectal circuit, including the microcircuitry formed by local tectal-tectal connections within the tectum. Second, we discuss the basic visual avoidance behavior generated specifically by this circuit, and how this behavior is being used as an assay to test visual system function.

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