Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
The complete sequence of a cloned cDNA derived from the major adult alpha-globin mRNA of Xenopus laevis (the South African Clawed Toad) is presented. The sequence contains the complete coding and 3' non-coding regions of the mRNA and part of the 5' non-coding region. The amino acid sequence of the encoded alpha-globin polypeptide has been deduced and is compared to other alpha-globin polypeptides. We find that the sequence is equally diverged from a bullfrog tadpole alpha-globin polypeptide and human alpha-globin polypeptide suggesting that these three sequences may have diverged from a common ancestral sequence several hundred million years ago.
Battaglia,
Isolation of globin messenger RNA of Xenopus laevis.
1977, Pubmed,
Xenbase
Battaglia,
Isolation of globin messenger RNA of Xenopus laevis.
1977,
Pubmed
,
Xenbase
Berkner,
Polynucleotide kinase exchange reaction: quantitave assay for restriction endonuclease-generated 5'-phosphoroyl termini in DNA.
1977,
Pubmed
Deacon,
Complete nucleotide sequence of a cloned chicken alpha-globin cDNA.
1980,
Pubmed
Goodman,
Darwinian evolution in the genealogy of haemoglobin.
1975,
Pubmed
Heindell,
The primary sequence of rabbit alpha-globin mRNA.
1978,
Pubmed
Hentschel,
Analysis of Xenopus laevis globins during development and erythroid cell maturation and the construction of recombinant plasmids containing sequences derived from adult globin mRNA.
1979,
Pubmed
,
Xenbase
Kay,
Molecular cloning of cDNA sequences coding for the major alpha- and beta-globin polypeptides of adult Xenopus laevis.
1980,
Pubmed
,
Xenbase
Maniatis,
Amplification and characterization of a beta-globin gene synthesized in vitro.
1976,
Pubmed
Maruyama,
Hemoglobins of the tadpole of the bullfrog, Rana catesbeiana. Amino acid sequence of the alpha chain of a major component.
1980,
Pubmed
Maxam,
Sequencing end-labeled DNA with base-specific chemical cleavages.
1980,
Pubmed
Nishioka,
The complete sequence of a chromosomal mouse alpha--globin gene reveals elements conserved throughout vertebrate evolution.
1979,
Pubmed
Partington,
Isolation of a Xenopus laevis alpha-globin gene.
1981,
Pubmed
,
Xenbase
Patient,
Internal organization of the major adult alpha- and beta-globin genes of X. laevis.
1980,
Pubmed
,
Xenbase
Richardson,
Partial sequence analysis of Xenopus alpha- and beta-globin mRNA as determined from recombinant DNA plasmids.
1980,
Pubmed
,
Xenbase
Soeda,
Sequence from early region of polyoma virus DNA containing viral replication origin and encoding small, middle and (part of) large T antigens.
1979,
Pubmed
Weaver,
Mapping of RNA by a modification of the Berk-Sharp procedure: the 5' termini of 15 S beta-globin mRNA precursor and mature 10 s beta-globin mRNA have identical map coordinates.
1979,
Pubmed
Williams,
The nucleotide sequence of the major beta-globin mRNA from Xenopus laevis.
1980,
Pubmed
,
Xenbase
Wilson,
Nucleotide sequence of the coding portion of human alpha globin messenger RNA.
1980,
Pubmed
Zain,
Nucleotide sequence analysis of the leader segments in a cloned copy of adenovirus 2 fiber mRNA.
1979,
Pubmed
