Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Proc Natl Acad Sci U S A
1992 Nov 01;8921:10484-8.
Show Gene links
Show Anatomy links
Glutamate receptors of Drosophila melanogaster: cloning of a kainate-selective subunit expressed in the central nervous system.
Ultsch A
,
Schuster CM
,
Laube B
,
Schloss P
,
Schmitt B
,
Betz H
.
???displayArticle.abstract???
We report the isolation and functional characterization of cDNAs encoding a Drosophila kainate-selective glutamate receptor. The deduced mature 964-residue protein (DGluR-I) is 108,482 Da and exhibits significant homology to mammalian glutamate receptor subunits. Injection of DGluR-I cRNA into Xenopus oocytes generated kainate-operated ion channels which were blocked by the selective non-N-methyl-D-aspartate receptor antagonist 6-cyano-7-nitro-quinoxaline-2,3-dione and philanthotoxin. DGluR-I transcripts are differentially expressed during Drosophila development and, in late embryogenesis, accumulate in the central nervous system.
Betz,
Ligand-gated ion channels in the brain: the amino acid receptor superfamily.
1990, Pubmed
Betz,
Ligand-gated ion channels in the brain: the amino acid receptor superfamily.
1990,
Pubmed
Blair,
Single subunits of the GABAA receptor form ion channels with properties of the native receptor.
1988,
Pubmed
,
Xenbase
Bolshakov VYu,
Different types of glutamate receptors in isolated and identified neurones of the mollusc Planorbarius corneus.
1991,
Pubmed
Cull-Candy,
Two types of extrajunctional L-glutamate receptors in locust muscle fibres.
1976,
Pubmed
Egebjerg,
Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA.
1991,
Pubmed
,
Xenbase
Fraser,
Amino acid receptors from insect muscle: electrophysiological characterization in Xenopus oocytes following expression by injection of mRNA.
1990,
Pubmed
,
Xenbase
Giles,
The effects of putative amino acid neurotransmitters on somata isolated from neurons of the locust central nervous system.
1985,
Pubmed
Harvey,
Sequence of a functional invertebrate GABAA receptor subunit which can form a chimeric receptor with a vertebrate alpha subunit.
1991,
Pubmed
,
Xenbase
Hermans-Borgmeyer,
Primary structure of a developmentally regulated nicotinic acetylcholine receptor protein from Drosophila.
1986,
Pubmed
Hollmann,
Cloning by functional expression of a member of the glutamate receptor family.
1989,
Pubmed
,
Xenbase
Horseman,
The effects of L-glutamate on cultured insect neurones.
1988,
Pubmed
Hutton,
Cloning of a cDNA that encodes an invertebrate glutamate receptor subunit.
1991,
Pubmed
Jan,
L-glutamate as an excitatory transmitter at the Drosophila larval neuromuscular junction.
1976,
Pubmed
Kawai,
Differential expression of glutamate receptors in Xenopus oocytes injected with messenger RNA from lobster muscle.
1988,
Pubmed
,
Xenbase
Keinänen,
A family of AMPA-selective glutamate receptors.
1990,
Pubmed
Kennedy,
Regulation of synaptic transmission in the central nervous system: long-term potentiation.
1989,
Pubmed
Kornfeld,
Structure and expression of a family of Ultrabithorax mRNAs generated by alternative splicing and polyadenylation in Drosophila.
1989,
Pubmed
Marshall,
Sequence and functional expression of a single alpha subunit of an insect nicotinic acetylcholine receptor.
1990,
Pubmed
,
Xenbase
Monaghan,
The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system.
1989,
Pubmed
Moriyoshi,
Molecular cloning and characterization of the rat NMDA receptor.
1991,
Pubmed
,
Xenbase
Needleman,
A general method applicable to the search for similarities in the amino acid sequence of two proteins.
1970,
Pubmed
Olney,
Excitotoxic amino acids and neuropsychiatric disorders.
1990,
Pubmed
Patlak,
Single glutamate-activated channels in locust muscle.
1979,
Pubmed
Sansom,
Single-channel studies of glutamate receptors.
1990,
Pubmed
Sawruk,
SBD, a novel structural subunit of the Drosophila nicotinic acetylcholine receptor, shares its genomic localization with two alpha-subunits.
1990,
Pubmed
Sawruk,
Heterogeneity of Drosophila nicotinic acetylcholine receptors: SAD, a novel developmentally regulated alpha-subunit.
1990,
Pubmed
,
Xenbase
Schmieden,
Functional expression in Xenopus oocytes of the strychnine binding 48 kd subunit of the glycine receptor.
1989,
Pubmed
,
Xenbase
Schuster,
Molecular cloning of an invertebrate glutamate receptor subunit expressed in Drosophila muscle.
1991,
Pubmed
,
Xenbase
Sommer,
Glutamate receptor channels: novel properties and new clones.
1992,
Pubmed
Sommer,
Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS.
1990,
Pubmed
Tautz,
A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback.
1989,
Pubmed
von Heijne,
A new method for predicting signal sequence cleavage sites.
1986,
Pubmed
Watkins,
Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists.
1990,
Pubmed
Werner,
Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells.
1991,
Pubmed
