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XB-ART-11886
Brain Res Mol Brain Res 1999 Nov 10;731-2:189-92. doi: 10.1016/s0169-328x(99)00247-8.
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A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.

Wood MW , VanDongen HM , VanDongen AM .


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Alanine 714 of the NMDA receptor NR1 subunit resides in the glycine binding pocket. The Ala714Leu mutation substantially shifts glycine affinity, but here no effect on antagonism by DCK is detected. Ala714Leu is also found to limit the efficacy of a partial agonist without altering its apparent affinity. The differential sensitivity of Ala714Leu to glycine agonists suggests that alanine 714 may be an intermediary in transducing the ligand binding signal.

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Species referenced: Xenopus laevis
Genes referenced: dck grin1 nodal1