Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Neuron
2004 Dec 16;446:909-16. doi: 10.1016/j.neuron.2004.11.030.
Show Gene links
Show Anatomy links
Calcium mediates bidirectional growth cone turning induced by myelin-associated glycoprotein.
Henley JR
,
Huang KH
,
Wang D
,
Poo MM
.
???displayArticle.abstract???
Cytoplasmic second messengers, Ca2+ and cAMP, regulate nervegrowth cone turning responses induced by many guidance cues, but the causal relationship between these signaling pathways has been unclear. We here report that, for growth cone turning induced by a gradient of myelin-associated glycoprotein (MAG), cAMP acts by modulating MAG-induced Ca2+ signaling. Growth cone repulsion induced by MAG was accompanied by localized Ca2+ signals on the side of the growth cone facing the MAG source, due to Ca2+ release from intracellular stores. Elevating cAMP signaling activity or membrane depolarization enhanced MAG-induced Ca2+ signals and converted growth cone repulsion to attraction. Directly imposing high- or low-amplitude Ca2+ signals with an extracellular gradient of Ca2+ ionophore was sufficient to trigger either attractive or repulsive turning, respectively. Thus, distinct Ca2+ signaling, which can be modulated by cAMP, mediates the bidirectional turning responses induced by MAG.
Bandtlow,
Role of intracellular calcium in NI-35-evoked collapse of neuronal growth cones.
1993, Pubmed
Bandtlow,
Role of intracellular calcium in NI-35-evoked collapse of neuronal growth cones.
1993,
Pubmed
Bruce,
Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling.
2002,
Pubmed
Cai,
Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism.
1999,
Pubmed
Choi,
Calcium and muscarinic agonist stimulation of type I adenylylcyclase in whole cells.
1992,
Pubmed
Domeniconi,
Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth.
2002,
Pubmed
Furuichi,
Intracellular channels.
1994,
Pubmed
Gorbunova,
Dynamic interactions of cyclic AMP transients and spontaneous Ca(2+) spikes.
2002,
Pubmed
,
Xenbase
Gu,
Distinct aspects of neuronal differentiation encoded by frequency of spontaneous Ca2+ transients.
1995,
Pubmed
,
Xenbase
Guirland,
Direct cAMP signaling through G-protein-coupled receptors mediates growth cone attraction induced by pituitary adenylate cyclase-activating polypeptide.
2003,
Pubmed
,
Xenbase
Hain,
Phosphorylation modulates the function of the calcium release channel of sarcoplasmic reticulum from cardiac muscle.
1995,
Pubmed
Henley,
Guiding neuronal growth cones using Ca2+ signals.
2004,
Pubmed
Hong,
Calcium signalling in the guidance of nerve growth by netrin-1.
2000,
Pubmed
,
Xenbase
Kater,
Regulation of growth cone behavior by calcium.
1991,
Pubmed
Liu,
Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor.
2002,
Pubmed
Liu,
Characterization of ionomycin as a calcium ionophore.
1978,
Pubmed
Lohof,
Asymmetric modulation of cytosolic cAMP activity induces growth cone turning.
1992,
Pubmed
,
Xenbase
Löschinger,
Retinal axon growth cone responses to different environmental cues are mediated by different second-messenger systems.
1997,
Pubmed
McKerracher,
Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth.
1994,
Pubmed
Ming,
Electrical activity modulates growth cone guidance by diffusible factors.
2001,
Pubmed
,
Xenbase
Ming,
Adaptation in the chemotactic guidance of nerve growth cones.
2002,
Pubmed
,
Xenbase
Ming,
Phospholipase C-gamma and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance.
1999,
Pubmed
,
Xenbase
Mukhopadhyay,
A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration.
1994,
Pubmed
Neumann,
Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation.
2002,
Pubmed
Nishiyama,
Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning.
2003,
Pubmed
,
Xenbase
Qiu,
Spinal axon regeneration induced by elevation of cyclic AMP.
2002,
Pubmed
Sato,
Susceptibility of the myelin-associated glycoprotein and basic protein to a neutral protease in highly purified myelin from human and rat brain.
1982,
Pubmed
Schäfer,
Disruption of the gene for the myelin-associated glycoprotein improves axonal regrowth along myelin in C57BL/Wlds mice.
1996,
Pubmed
Sculptoreanu,
Voltage-dependent potentiation of L-type Ca2+ channels due to phosphorylation by cAMP-dependent protein kinase.
1993,
Pubmed
Sivasankaran,
PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration.
2004,
Pubmed
Song,
cAMP-induced switching in turning direction of nerve growth cones.
1997,
Pubmed
,
Xenbase
Song,
Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides.
1998,
Pubmed
,
Xenbase
Spitzer,
The development of the action potential mechanism of amphibian neurons isolated in culture.
1976,
Pubmed
,
Xenbase
Tang,
Soluble myelin-associated glycoprotein (MAG) found in vivo inhibits axonal regeneration.
1997,
Pubmed
Tang,
Expression and characterization of calmodulin-activated (type I) adenylylcyclase.
1991,
Pubmed
Thastrup,
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.
1990,
Pubmed
Wang,
P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.
2002,
Pubmed
Wong,
A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein.
2002,
Pubmed
,
Xenbase
Xia,
Calmodulin-regulated adenylyl cyclases and neuromodulation.
1997,
Pubmed
Yamashita,
The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho.
2002,
Pubmed
Zheng,
Turning of nerve growth cones induced by localized increases in intracellular calcium ions.
2000,
Pubmed
,
Xenbase
Zheng,
Turning of nerve growth cones induced by neurotransmitters.
1994,
Pubmed
,
Xenbase
Zucchi,
The sarcoplasmic reticulum Ca2+ channel/ryanodine receptor: modulation by endogenous effectors, drugs and disease states.
1997,
Pubmed
