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Activation of protein kinase C differentially modulates neuronal Na+, Ca2+, and gamma-aminobutyrate type A channels.
Sigel E
,
Baur R
.
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Xenopus oocytes were used to study the interaction of neuronal quisqualate receptors with neuronal ion channels. Total mRNA was isolated from chick forebrain and injected into Xenopus oocytes. This technique led to the expression of functional voltage-gated Na+ and Ca2+ channels, of ligand-gated gamma-aminobutyrate and kainate receptor channels, and of quisqualate receptors that could activate endogenous chloride channels by means of inositol trisphosphate-mediated Ca2+ release. Exposure of the oocytes to quisqualate decreased the amplitude of the Na+ current and of the gamma-aminobutyrate type A-gated current and increased the amplitude of the Ba2+ current through Ca2+ channels. This modulation of neuronal ion channels by quisqualate could be mimicked by the protein kinase C activator phorbol 12-myristate 13-acetate and the diacylglycerol analogue 1,2-oleoylacetylglycerol. The kainate-gated channel was not affected by these agents. Phorbol esters that do not activate protein kinase C, alpha-phorbol 12-myristate 13-acetate and alpha-phorbol, were without effect. The inhibitor of protein kinase C, tamoxifen, prevented the modulatory effects of phorbol 12-myristate 13-acetate. The present evidence suggests that the activity of the neuronal Na+ and Ca2+ channels and the ligand-gated gamma-aminobutyrate type A receptor channel are under the control of protein kinase C and that neurotransmitters that activate protein kinase C could profoundly affect neuronal signaling.
Artola,
Long-term potentiation and NMDA receptors in rat visual cortex.
, Pubmed
Artola,
Long-term potentiation and NMDA receptors in rat visual cortex.
,
Pubmed
Baraban,
Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons: electrophysiological effects of phorbol esters.
1985,
Pubmed
Barish,
A transient calcium-dependent chloride current in the immature Xenopus oocyte.
1983,
Pubmed
,
Xenbase
Barnard,
Translation of exogenous messenger RNA coding for nicotinic acetylcholine receptors produces functional receptors in Xenopus oocytes.
1982,
Pubmed
,
Xenbase
Belin,
Immunohistochemical evidence for the presence of gamma-aminobutyric acid and serotonin in one nerve cell. A study on the raphe nuclei of the rat using antibodies to glutamate decarboxylase and serotonin.
1983,
Pubmed
Berridge,
Inositol trisphosphate and diacylglycerol as second messengers.
1984,
Pubmed
Cathala,
A method for isolation of intact, translationally active ribonucleic acid.
1983,
Pubmed
Costa,
Phosphorylation of the alpha subunit of the sodium channel by protein kinase C.
1984,
Pubmed
Cull-Candy,
Multiple-conductance channels activated by excitatory amino acids in cerebellar neurons.
,
Pubmed
Dascal,
Expression and modulation of voltage-gated calcium channels after RNA injection in Xenopus oocytes.
1986,
Pubmed
,
Xenbase
DeRiemer,
Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C.
,
Pubmed
Farley,
Protein kinase C activation induces conductance changes in Hermissenda photoreceptors like those seen in associative learning.
,
Pubmed
Foster,
Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationship to synaptic receptors.
1984,
Pubmed
Galizzi,
Regulation of calcium channels in aortic muscle cells by protein kinase C activators (diacylglycerol and phorbol esters) and by peptides (vasopressin and bombesin) that stimulate phosphoinositide breakdown.
1987,
Pubmed
Gundersen,
Glutamate and kainate receptors induced by rat brain messenger RNA in Xenopus oocytes.
1984,
Pubmed
,
Xenbase
Gundersen,
Messenger RNA from human brain induces drug- and voltage-operated channels in Xenopus oocytes.
,
Pubmed
,
Xenbase
Gusovsky,
Regulation of phosphatidylinositol turnover in brain synaptoneurosomes: stimulatory effects of agents that enhance influx of sodium ions.
1986,
Pubmed
Hammond,
Cholecystokinin induces a decrease in Ca2+ current in snail neurons that appears to be mediated by protein kinase C.
,
Pubmed
Hirono,
Neurotensin and acetylcholine evoke common responses in frog oocytes injected with rat brain messenger ribonucleic acid.
1987,
Pubmed
,
Xenbase
Houamed,
Expression of functional GABA, glycine and glutamate receptors in Xenopus oocytes injected with rat brain mRNA.
,
Pubmed
,
Xenbase
Jahr,
Glutamate activates multiple single channel conductances in hippocampal neurons.
,
Pubmed
Kaibuchi,
Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.
1983,
Pubmed
Kishimoto,
Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.
1980,
Pubmed
Leonard,
Ca channels induced in Xenopus oocytes by rat brain mRNA.
1987,
Pubmed
,
Xenbase
Levitan,
Phosphorylation of ion channels.
1985,
Pubmed
Malenka,
Potentiation of synaptic transmission in the hippocampus by phorbol esters.
,
Pubmed
Nishizuka,
The role of protein kinase C in cell surface signal transduction and tumour promotion.
,
Pubmed
Olsen,
Drug interactions at the GABA receptor-ionophore complex.
1982,
Pubmed
Rane,
Kinase C activator 1,2-oleoylacetylglycerol attenuates voltage-dependent calcium current in sensory neurons.
1986,
Pubmed
Rossie,
Cyclic-AMP-dependent phosphorylation of voltage-sensitive sodium channels in primary cultures of rat brain neurons.
1987,
Pubmed
Sekar,
The role of phosphoinositides in signal transduction.
1986,
Pubmed
Sigel,
Properties of single sodium channels translated by Xenopus oocytes after injection with messenger ribonucleic acid.
1987,
Pubmed
,
Xenbase
Sigel,
Allosteric modulation by benzodiazepine receptor ligands of the GABAA receptor channel expressed in Xenopus oocytes.
1988,
Pubmed
,
Xenbase
Sigel,
Effect of avermectin B1a on chick neuronal gamma-aminobutyrate receptor channels expressed in Xenopus oocytes.
1987,
Pubmed
,
Xenbase
Strong,
Stimulation of protein kinase C recruits covert calcium channels in Aplysia bag cell neurons.
,
Pubmed
Su,
Effect of tamoxifen, a nonsteroidal antiestrogen, on phospholipid/calcium-dependent protein kinase and phosphorylation of its endogenous substrate proteins from the rat brain and ovary.
1985,
Pubmed
Sugiyama,
A new type of glutamate receptor linked to inositol phospholipid metabolism.
,
Pubmed
,
Xenbase
