XB-ART-28609
Anal Biochem
1986 Jul 01;1561:257-62. doi: 10.1016/0003-2697(86)90181-8.
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Li+ uptake into Xenopus and Cynops oocytes injected with exogenous mRNA, observed by flame emission spectroscopy.
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Li+ uptake into Xenopus oocytes was measured by flame emission spectroscopy. Li+ uptake into the oocytes increased proportionally with incubation time and was dependent on either pH or temperature. Maximum uptake of Li+ was observed around pH 7. Li+ uptake into Xenopus oocytes increased by a factor of roughly 7 over the range 4-30 degrees C. When mRNA prepared from electroplax of Electrophorus electricus was injected into Xenopus or Cynops oocytes, Li+ uptake into the injected oocytes increased by the addition of carbamylcholine (Carb), an agonist of the acetylcholine receptor (AChR). This increase of Li+ uptake by Carb was inhibited by d-tubocurarine, an antagonist of nicotinic AChR. Thus, a new method was established for detection of the activity of nicotinic AChR synthesized in oocytes injected with exogenous mRNA.
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