XB-ART-12546
Semin Cell Dev Biol
1999 Jun 01;103:311-7. doi: 10.1006/scdb.1999.0307.
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Activin as a morphogen in Xenopus mesoderm induction.
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Activin, a member of the Transforming Growth Factor beta (TGF-beta) superfamily, can behave as a morphogen in cells of the early Xenopus embryo by inducing a range of mesodermal genes in a concentration-dependent manner. This review examines the behaviour of activin as it forms a morphogen gradient. It also discusses how a cell can perceive its position in a concentration gradient in order to activate appropriate mesodermal gene responses.
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Species referenced: Xenopus
Genes referenced: tgfb1