Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Proc Natl Acad Sci U S A
1998 Dec 08;9525:14729-32. doi: 10.1073/pnas.95.25.14729.
Show Gene links
Show Anatomy links
Cleavage planes in frog eggs are altered by strong magnetic fields.
Denegre JM
,
Valles JM
,
Lin K
,
Jordan WB
,
Mowry KL
.
???displayArticle.abstract???
Early cleavages of Xenopus embryos were oriented in strong, static magnetic fields. Third-cleavage planes, normally horizontal, were seen to orient to a vertical plane parallel with a vertical magnetic field. Second cleavages, normally vertical, could also be oriented by applying a horizontal magnetic field. We argue that these changes in cleavage-furrow geometries result from changes in the orientation of the mitotic apparatus. We hypothesize that the magnetic field acts directly on the microtubules of the mitotic apparatus. Considerations of the length of the astral microtubules, their diamagnetic anisotropy, and flexural rigidity predict the required field strength for an effect that agrees with the data. This observation provides a clear example of a static magnetic-field effect on a fundamental cellular process, cell division.
Bjerknes,
Physical theory of the orientation of astral mitotic spindles.
1986, Pubmed
Bjerknes,
Physical theory of the orientation of astral mitotic spindles.
1986,
Pubmed
Black,
The first cleavage plane and the embryonic axis are determined by separate mechanisms in Xenopus laevis. II. Experimental dissociation by lateral compression of the egg.
1988,
Pubmed
,
Xenbase
Bras,
The susceptibility of pure tubulin to high magnetic fields: a magnetic birefringence and x-ray fiber diffraction study.
1998,
Pubmed
Danilchik,
The first cleavage plane and the embryonic axis are determined by separate mechanisms in Xenopus laevis. I. Independence in undisturbed embryos.
1988,
Pubmed
,
Xenbase
Denegre,
Localized maternal proteins in Xenopus revealed by subtractive immunization.
1997,
Pubmed
,
Xenbase
Dogterom,
Measurement of the force-velocity relation for growing microtubules.
1997,
Pubmed
Gard,
Confocal immunofluorescence microscopy of microtubules in amphibian oocytes and eggs.
1993,
Pubmed
,
Xenbase
Gard,
Confocal immunofluorescence microscopy of microtubules, microtubule-associated proteins, and microtubule-organizing centers during amphibian oogenesis and early development.
1995,
Pubmed
,
Xenbase
Holy,
Assembly and positioning of microtubule asters in microfabricated chambers.
1997,
Pubmed
Hong,
Magnetic anisotropy and the orientation of retinal rods in a homogeneous magnetic field.
1971,
Pubmed
Inoué,
Dynamics of mitosis and cleavage.
1990,
Pubmed
Rappaport,
Establishment of the mechanism of cytokinesis in animal cells.
1986,
Pubmed
Torbet,
Oriented fibrin gels formed by polymerization in strong magnetic fields.
1981,
Pubmed
Valles,
Stable magnetic field gradient levitation of Xenopus laevis: toward low-gravity simulation.
1997,
Pubmed
,
Xenbase
White,
Cleavage plane specification in C. elegans: how to divide the spoils.
1996,
Pubmed