Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-28178
FEBS Lett 1987 Apr 20;2142:253-8.
Show Gene links Show Anatomy links

Functional properties of nicotinic acetylcholine receptor subunits expressed in various combinations.

Kurosaki T , Fukuda K , Konno T , Mori Y , Tanaka K , Mishina M , Numa S .


???displayArticle.abstract???
The four kinds of subunits of the Torpedo californica nicotinic acetylcholine receptor have been produced in various combinations by injecting Xenopus oocytes with the corresponding subunit-specific mRNAs synthesized by transcription in vitro of the cloned cDNAs. Functional analysis suggests that association of the alpha-subunit with either the gamma- or the delta-subunit is a prerequisite for generating the conformation necessary for agonist binding. The acetylcholine receptor devoid of either the beta-, gamma- or delta-subunit exhibits weak channel activity.

???displayArticle.pubmedLink??? 2436944