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Protocadherins have homophilic adhesion properties and mediate selective cell-cell adhesion and cell sorting. Knockdown of paraxial protocadherin (PAPC) function in the Xenopus embryo impairs tissue separation, a process that regulates separation of cells of ectodermal and mesodermal origin during gastrulation. We show that PAPC can modulate the activity of the Rho GTPase and c-jun N-terminal kinase, two regulators of the cytoskeletal architecture and effectors of the planar cell polarity pathway. This novel signaling function of PAPC is essential for the regulation of tissue separation. In addition, PAPC can interact with the Xenopus Frizzled 7 receptor, and both proteins contribute to the development of separation behavior by activating Rho and protein kinase Calpha.
Alagramam,
The mouse Ames waltzer hearing-loss mutant is caused by mutation of Pcdh15, a novel protocadherin gene.
2001, Pubmed
Alagramam,
The mouse Ames waltzer hearing-loss mutant is caused by mutation of Pcdh15, a novel protocadherin gene.
2001,
Pubmed
Alagramam,
Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F.
2001,
Pubmed
Bradley,
NF-protocadherin, a novel member of the cadherin superfamily, is required for Xenopus ectodermal differentiation.
1998,
Pubmed
,
Xenbase
Clark,
Dachsous encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis in Drosophila.
1995,
Pubmed
Das,
The atypical cadherin Flamingo links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye.
2002,
Pubmed
Davidson,
Mesendoderm extension and mantle closure in Xenopus laevis gastrulation: combined roles for integrin alpha(5)beta(1), fibronectin, and tissue geometry.
2002,
Pubmed
,
Xenbase
Davis,
Signal transduction by the JNK group of MAP kinases.
2000,
Pubmed
Epstein,
Patterning of the embryo along the anterior-posterior axis: the role of the caudal genes.
1997,
Pubmed
,
Xenbase
Frank,
Protocadherins.
2002,
Pubmed
Green,
Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate.
1990,
Pubmed
,
Xenbase
Habas,
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation.
2003,
Pubmed
,
Xenbase
Hadeball,
Xenopus cadherin-11 (Xcadherin-11) expression requires the Wg/Wnt signal.
1998,
Pubmed
,
Xenbase
Heggem,
The cytoplasmic domain of Xenopus NF-protocadherin interacts with TAF1/set.
2003,
Pubmed
,
Xenbase
Heisenberg,
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation.
2000,
Pubmed
Homayouni,
Disabled-1 interacts with a novel developmentally regulated protocadherin.
2001,
Pubmed
Huelsken,
New aspects of Wnt signaling pathways in higher vertebrates.
2001,
Pubmed
,
Xenbase
Hukriede,
Conserved requirement of Lim1 function for cell movements during gastrulation.
2003,
Pubmed
,
Xenbase
Keller,
Mechanisms of convergence and extension by cell intercalation.
2000,
Pubmed
Keller,
Cellular basis of amphibian gastrulation.
1992,
Pubmed
Kim,
The protocadherin PAPC establishes segmental boundaries during somitogenesis in xenopus embryos.
2000,
Pubmed
,
Xenbase
Kim,
The role of paraxial protocadherin in selective adhesion and cell movements of the mesoderm during Xenopus gastrulation.
1998,
Pubmed
,
Xenbase
Kohmura,
Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.
1998,
Pubmed
Kuroda,
Axial protocadherin is a mediator of prenotochord cell sorting in Xenopus.
2002,
Pubmed
,
Xenbase
Leckband,
Mechanism of homophilic cadherin adhesion.
2000,
Pubmed
Ma,
Fidelity in planar cell polarity signalling.
2003,
Pubmed
Medina,
Xenopus frizzled 7 can act in canonical and non-canonical Wnt signaling pathways: implications on early patterning and morphogenesis.
2000,
Pubmed
,
Xenbase
Mlodzik,
Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?
2002,
Pubmed
Narumiya,
Signal transduction underlying cell morphogenesis: editorial overview.
2003,
Pubmed
Nobes,
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia.
1995,
Pubmed
Ohan,
RHO-associated protein kinase alpha potentiates insulin-induced MAP kinase activation in Xenopus oocytes.
1999,
Pubmed
,
Xenbase
Peifer,
The ballet of morphogenesis: unveiling the hidden choreographers.
2002,
Pubmed
,
Xenbase
Reintsch,
Dorsoventral differences in cell-cell interactions modulate the motile behaviour of cells from the Xenopus gastrula.
2001,
Pubmed
,
Xenbase
Ren,
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton.
1999,
Pubmed
Sasai,
Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes.
1994,
Pubmed
,
Xenbase
Smith,
Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center.
1991,
Pubmed
,
Xenbase
Tada,
Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway.
2000,
Pubmed
,
Xenbase
Tahinci,
Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulation.
2003,
Pubmed
,
Xenbase
Takeichi,
Cadherin cell adhesion receptors as a morphogenetic regulator.
1991,
Pubmed
TIEDEMANN,
[Experiments on the chemical identification of embryonal induction substances].
1956,
Pubmed
Veeman,
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
2003,
Pubmed
Wacker,
Development and control of tissue separation at gastrulation in Xenopus.
2000,
Pubmed
,
Xenbase
Wallingford,
Dishevelled controls cell polarity during Xenopus gastrulation.
2000,
Pubmed
,
Xenbase
Winklbauer,
Vegetal rotation, a new gastrulation movement involved in the internalization of the mesoderm and endoderm in Xenopus.
1999,
Pubmed
,
Xenbase
Winklbauer,
Frizzled-7 signalling controls tissue separation during Xenopus gastrulation.
2001,
Pubmed
,
Xenbase
Wünnenberg-Stapleton,
Involvement of the small GTPases XRhoA and XRnd1 in cell adhesion and head formation in early Xenopus development.
1999,
Pubmed
,
Xenbase
Yamanaka,
JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates.
2002,
Pubmed
,
Xenbase
Yang,
Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye.
2002,
Pubmed
Yoshida,
BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain.
1999,
Pubmed
