Lade AG , Monga SP .

R01 CA124414 NCI NIH HHS , R01 DK062277 NIDDK NIH HHS , T32 EB001026 NIBIB NIH HHS

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Aberle, Single amino acid substitutions in proteins of the armadillo gene family abolish their binding to alpha-catenin. 1996, Pubmed
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Aberle, beta-catenin is a target for the ubiquitin-proteasome pathway. 1997, Pubmed
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Apte, Wnt/beta-catenin signaling mediates oval cell response in rodents. 2008, Pubmed
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Barrow, Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. 2007, Pubmed
Battle, Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. 2006, Pubmed
Bayha, Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis. 2009, Pubmed
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Benhamouche, Apc tumor suppressor gene is the "zonation-keeper" of mouse liver. 2006, Pubmed
Berg, Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation. 2007, Pubmed
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Bi, Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells. 2009, Pubmed
Bort, Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development. 2006, Pubmed
Brembeck, Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. 2004, Pubmed
Brennan, Nodal activity in the node governs left-right asymmetry. 2002, Pubmed
Brennan, Nodal signalling in the epiblast patterns the early mouse embryo. 2001, Pubmed
Burke, The Wnt/beta-catenin pathway: master regulator of liver zonation? 2006, Pubmed
Butler, The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthetase 1. 2008, Pubmed
Cheng, HNF factors form a network to regulate liver-enriched genes in zebrafish. 2006, Pubmed
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Clotman, Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors. 2005, Pubmed
Clotman, The onecut transcription factor HNF6 is required for normal development of the biliary tract. 2002, Pubmed
Coffinier, Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1beta. 2002, Pubmed
Colletti, Convergence of Wnt signaling on the HNF4alpha-driven transcription in controlling liver zonation. 2009, Pubmed
Conlon, A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. 1994, Pubmed
Cook, Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C. 1996, Pubmed
Crawford, Histology atlas of the developing mouse hepatobiliary system with emphasis on embryonic days 9.5-18.5. 2010, Pubmed
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Ehrman, Anterior expression of the caudal homologue cCdx-B activates a posterior genetic program in avian embryos. 2001, Pubmed
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Erker, Signaling networks in hepatic oval cell activation. 2007, Pubmed
Finley, The mouse secreted frizzled-related protein 5 gene is expressed in the anterior visceral endoderm and foregut endoderm during early post-implantation development. 2003, Pubmed
Friedman, Orthogonal analysis of C/EBPbeta targets in vivo during liver proliferation. 2004, Pubmed
Gadue, Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. 2006, Pubmed
Galli, Differential inhibition of Wnt-3a by Sfrp-1, Sfrp-2, and Sfrp-3. 2006, Pubmed
Gao, Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. 1998, Pubmed
Germain, Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. 2000, Pubmed , Xenbase
Giera, Wnt/beta-catenin signaling activates and determines hepatic zonal expression of glutathione S-transferases in mouse liver. 2010, Pubmed
Gkretsi, Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. 2008, Pubmed
Goessling, APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. 2008, Pubmed
Graham, Crystal structure of a beta-catenin/Tcf complex. 2000, Pubmed , Xenbase
Hagos, The role of maternal Activin-like signals in zebrafish embryos. 2007, Pubmed , Xenbase
Hand, The microRNA-30 family is required for vertebrate hepatobiliary development. 2009, Pubmed
Haramoto, Xenopus tropicalis nodal-related gene 3 regulates BMP signaling: an essential role for the pro-region. 2004, Pubmed , Xenbase
Hart, The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. 1999, Pubmed
Heller, Misexpression of the pancreatic homeodomain protein IDX-1 by the Hoxa-4 promoter associated with agenesis of the cecum. 1998, Pubmed
Howard, Regulation of the Xenopus Xsox17alpha(1) promoter by co-operating VegT and Sox17 sites. 2007, Pubmed , Xenbase
Hu, Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells. 2007, Pubmed
Huber, Nuclear localization of beta-catenin by interaction with transcription factor LEF-1. 1996, Pubmed , Xenbase
Hudson, Xsox17alpha and -beta mediate endoderm formation in Xenopus. 1997, Pubmed , Xenbase
Huelsken, Requirement for beta-catenin in anterior-posterior axis formation in mice. 2000, Pubmed
Hunter, The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis. 2007, Pubmed
Hussain, Wnt impacts growth and differentiation in ex vivo liver development. 2004, Pubmed
Ikeda, Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. 1998, Pubmed
Imamura, Oncostatin M induces upregulation of claudin-2 in rodent hepatocytes coinciding with changes in morphology and function of tight junctions. 2007, Pubmed
Jacquemin, Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2. 2003, Pubmed
Jung, Initiation of mammalian liver development from endoderm by fibroblast growth factors. 1999, Pubmed
Kamiya, Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. 1999, Pubmed
Kamiya, TNF-alpha regulates mouse fetal hepatic maturation induced by oncostatin M and extracellular matrices. 2004, Pubmed
Kanai-Azuma, Depletion of definitive gut endoderm in Sox17-null mutant mice. 2002, Pubmed
Kelly, The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. 2001, Pubmed
Kelly, The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. 2004, Pubmed
Kemler, Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. 2004, Pubmed
Kemp, Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development. 2005, Pubmed
Kodama, The role of notch signaling in the development of intrahepatic bile ducts. 2004, Pubmed
Kumar, Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate. 2003, Pubmed
Kyrmizi, Plasticity and expanding complexity of the hepatic transcription factor network during liver development. 2006, Pubmed
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Lemaigre, Development of the biliary tract. 2003, Pubmed
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Li, Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha. 2000, Pubmed
Lilien, The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin. 2005, Pubmed
Lindsley, Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. 2006, Pubmed
Liu, Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. 2002, Pubmed , Xenbase
Liu, Requirement for Wnt3 in vertebrate axis formation. 1999, Pubmed
Liu, Coordinated molecular control of otic capsule differentiation: functional role of Wnt5a signaling and opposition by sfrp3 activity. 2008, Pubmed
Loeppen, A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors. 2005, Pubmed
Loomes, Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage. 2007, Pubmed
Lozier, Notch signaling regulates bile duct morphogenesis in mice. 2008, Pubmed
Lu, Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning. 2004, Pubmed
Luzzatto, Hepatocyte differentiation during early fetal development in the rat. 1981, Pubmed
Margagliotti, The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration. 2007, Pubmed
Margagliotti, Role of metalloproteinases at the onset of liver development. 2008, Pubmed
Martín, Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. 2005, Pubmed
Matsui, K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development. 2002, Pubmed
Matsui, Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. 2005, Pubmed , Xenbase
Matsumoto, Wnt9a secreted from the walls of hepatic sinusoids is essential for morphogenesis, proliferation, and glycogen accumulation of chick hepatic epithelium. 2008, Pubmed
Matsumoto, Liver organogenesis promoted by endothelial cells prior to vascular function. 2001, Pubmed
McCrea, A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin. 1991, Pubmed , Xenbase
McCrea, Purification of a 92-kDa cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvomorulin). Characterization and extractability of the protein complex from the cell cytostructure. 1991, Pubmed , Xenbase
McLin, Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development. 2007, Pubmed , Xenbase
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Michalopoulos, HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures. 2003, Pubmed
Micsenyi, Beta-catenin is temporally regulated during normal liver development. 2004, Pubmed
Mikels, Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. 2006, Pubmed
Mohamed, Beta-catenin signaling marks the prospective site of primitive streak formation in the mouse embryo. 2004, Pubmed , Xenbase
Monga, Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes. 2002, Pubmed
Monga, Role of Wnt/β-catenin signaling in liver metabolism and cancer. 2011, Pubmed
Monga, Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification. 2003, Pubmed
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Nakamura, Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level. 1998, Pubmed
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Naldini, Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. 1991, Pubmed
Negishi, Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka. 2010, Pubmed
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Nyeng, FGF10 signaling controls stomach morphogenesis. 2007, Pubmed
Nyeng, FGF10 maintains distal lung bud epithelium and excessive signaling leads to progenitor state arrest, distalization, and goblet cell metaplasia. 2008, Pubmed
Ober, Mesodermal Wnt2b signalling positively regulates liver specification. 2006, Pubmed
Odom, Control of pancreas and liver gene expression by HNF transcription factors. 2004, Pubmed
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Onuma, Xnr2 and Xnr5 unprocessed proteins inhibit Wnt signaling upstream of dishevelled. 2005, Pubmed , Xenbase
Ornitz, Fibroblast growth factors. 2001, Pubmed
Ozawa, Altered cell adhesion activity by pervanadate due to the dissociation of alpha-catenin from the E-cadherin.catenin complex. 1998, Pubmed
Papkoff, Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes. 1996, Pubmed
Papkoff, WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells. 1998, Pubmed
Parviz, Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. 2003, Pubmed
Perea-Gomez, Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks. 2002, Pubmed
Piedra, p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. 2003, Pubmed
Piedra, Regulation of beta-catenin structure and activity by tyrosine phosphorylation. 2001, Pubmed
Pilcher, Expression of the Wnt inhibitor, sFRP5, in the gut endoderm of Xenopus. 2002, Pubmed , Xenbase
Preisegger, Atypical ductular proliferation and its inhibition by transforming growth factor beta1 in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine mouse model for chronic alcoholic liver disease. 1999, Pubmed
Qian, Wnt5a functions in planar cell polarity regulation in mice. 2007, Pubmed , Xenbase
Rastegar, CCAAT/enhancer-binding protein-alpha is a component of the growth hormone-regulated network of liver transcription factors. 2000, Pubmed
Rhee, Cables links Robo-bound Abl kinase to N-cadherin-bound beta-catenin to mediate Slit-induced modulation of adhesion and transcription. 2007, Pubmed , Xenbase
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Roberts, Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut. 1995, Pubmed
Rossi, Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. 2001, Pubmed
Roura, Regulation of E-cadherin/Catenin association by tyrosine phosphorylation. 1999, Pubmed
Rubinfeld, Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. 1996, Pubmed
Sakanaka, Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function. 1999, Pubmed , Xenbase
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Sell, Liver cancer stem cells. 2008, Pubmed
Serls, Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. 2005, Pubmed
Shin, Bmp and Fgf signaling are essential for liver specification in zebrafish. 2007, Pubmed
Simion, MiR-495 and miR-218 regulate the expression of the Onecut transcription factors HNF-6 and OC-2. 2010, Pubmed
Sinner, Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes. 2004, Pubmed , Xenbase
Spee, Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling. 2010, Pubmed
Stafford, A conserved role for retinoid signaling in vertebrate pancreas development. 2004, Pubmed , Xenbase
Strick-Marchand, Inducible differentiation and morphogenesis of bipotential liver cell lines from wild-type mouse embryos. 2002, Pubmed
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Tan, Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development. 2008, Pubmed
Tatsumi, Neurturin-GFRalpha2 signaling controls liver bud migration along the ductus venosus in the chick embryo. 2007, Pubmed
Thompson, Disparate cellular basis of improved liver repair in beta-catenin-overexpressing mice after long-term exposure to 3,5-diethoxycarbonyl-1,4-dihydrocollidine. 2010, Pubmed
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