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Dual innervation of end-plate sites and its consequences for neuromuscular transmission in muscles of adult Xenopus laevis.
Angaut-Petit D
,
Mallart A
.
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1. Electrophysiological study of dually innervated end-plate sites was carried out in Xenopus laevis pectoral muscle fibres. End-plate potentials (e.p.p.s) and miniature end-plate potentials (m.e.p.p.s) have been recorded in Mg-blocked preparations. 2. The mean quantal content (m) of each e.p.p. at dually innervated end-plates was significantly smaller than the corresponding values obtained at singly innervated ones. At a given doubly innervated end-plate site the values of m tended to be inversely related, so that the compound value of m (obtained by adding them) was in the same range as that found in singly innervated junctions. These findings were taken to suggest the existence of an upper limit in the average amount of transmitter released at a synaptic site. 3. It was found that neither intermittent presynaptic conduction block, nor particular muscle fibre properties could account for the low values of m in dual end plates. The small size of the nerve terminals appears to be the most likely explanation. 4. The sensitivity to acetylcholine and muscle fibre electrical properties were investigated; no differences were found between fibres with sub- or suprathreshold e.p.p.s. 5. The nature of the factors responsible for this presumed small size of the nerve endings (competition between nerve endings for a limited synaptic space on the muscle membrane or reciprocal interaction between closely located terminals) as well as the possible origins of polyinnervation are discussed.
Adams,
Upper and lower bounds on the non-linearity of summation of end-plate potentials.
1976, Pubmed
Adams,
Upper and lower bounds on the non-linearity of summation of end-plate potentials.
1976,
Pubmed
Aguilar,
Evidence that axoplasmic transport of trophic factors is involved in the regulation of peripheral nerve fields in salamanders.
1973,
Pubmed
Bennett,
The formation of synapses in amphibian striated muscle during development.
1975,
Pubmed
Bennett,
The formation and regression of synapses during the re-innervation of axolotl striated muscles.
1977,
Pubmed
Benoit,
Consequences of tenotomy on the evolution of multiinnervation in developing rat soleus muscle.
1975,
Pubmed
Bittner,
A reconsideration of the Poisson hypothesis for transmitter release at the crayfish neuromuscular junction.
1970,
Pubmed
Brown,
Polyneuronal innervation of skeletal muscle in new-born rats and its elimination during maturation.
1976,
Pubmed
Brown,
Sprouting and regression of neuromuscular synapses in partially denervated mammalian muscles.
1978,
Pubmed
BROWN,
An investigation into the possible existence of polyneuronal innervation of individual skeletal muscle fibres in certain hind-limb muscles of the cat.
1960,
Pubmed
Cooper,
The effects of nerve section and of colchicine treatment on the density of mechanosensory nerve endings in salamander skin.
1977,
Pubmed
DEL CASTILLO,
Quantal components of the end-plate potential.
1954,
Pubmed
DEL CASTILLO,
The nature of the neuromuscular block produced by magnesium.
1954,
Pubmed
Dennis,
Characteristics of transmitter release at regenerating frog neuromuscular junctions.
1974,
Pubmed
Diamond,
Trophic regulation of nerve sprouting.
1976,
Pubmed
Dreyer,
Iontophoretic application of acetylcholine: advantages of high resistance micropipettes in connection with an electronic current pump.
1974,
Pubmed
FATT,
An analysis of the end-plate potential recorded with an intracellular electrode.
1951,
Pubmed
Feltz,
An analysis of acetylcholine responses of junctional and extrajunctional receptors of frog muscle fibres.
1971,
Pubmed
Fex,
Nerve implants in botulinum poisoned mammalian muscle.
1966,
Pubmed
Gage,
An analysis of the relationship between the current and potential generated by a quantum of acetylcholine in muscle fibers without transverse tubules.
1973,
Pubmed
Grinnell,
Mutual repression of synaptic efficacy by pairs of foreign nerves innervating frog skeletal muscle.
1977,
Pubmed
Hatt,
Synaptic depression related to presynaptic axon conduction block.
1976,
Pubmed
HOFFMAN,
Fate of interrupted nerve-fibres regenerating into partially denervated muscles.
1951,
Pubmed
HUBBARD,
The electrical constants and the component conductances of frog skeletal muscle after denervation.
1963,
Pubmed
Jansen,
Hyperinnervation of skeletal muscle fibers: dependence on muscle activity.
1973,
Pubmed
Kuffler,
The elimination of synapses in multiply-innervated skeletal muscle fibres of the rat: dependence on distance between end-plates.
1977,
Pubmed
Kuno,
Correlation between nerve terminal size and transmitter release at the neuromuscular junction of the frog.
1971,
Pubmed
Letinsky,
The development of nerve-muscle junctions in Rana catesbeiana tadpoles.
1974,
Pubmed
Letinsky,
Acetylcholine sensitivity changes in tadpole tail muscle fibers innervated by developing motor neurons.
1975,
Pubmed
Lømo,
Control of acetylcholine sensitivity and synapse formation by muscle activity.
1978,
Pubmed
Magherini,
Electrical properties of frog motoneurons in the in situ spinal cord.
1976,
Pubmed
Mallart,
The effects of pH and curare on the time course of end-plate currents at the neuromuscular junction of the frog.
1978,
Pubmed
Nakajima,
Double sucrose-gap method applied to single muscle fiber of Xenopus laevis.
1974,
Pubmed
,
Xenbase
Redfern,
Neuromuscular transmission in new-born rats.
1970,
Pubmed
Rotshenker,
Altered patterns of innervation in frog muscle after denervation.
1976,
Pubmed
Stefani,
Resting potential and electrical properties of frog slow muscle fibres. Effect of different external solutions.
1969,
Pubmed
Tuffery,
Growth and degeneration of motor end-plates in normal cat hind limb muscles.
1971,
Pubmed
Van Harreveld,
Innervation and reinnervation of cricothyroid muscle in the rabbit.
1961,
Pubmed
Vigny,
Active-site catalytic efficiency of acetylcholinesterase molecular forms in Electrophorus, torpedo, rat and chicken.
1978,
Pubmed
Vyskocil,
Dual end-plate potentials at the single neuromuscular junction of the adult frog.
1977,
Pubmed
Wernig,
Estimates of statistical release parameters from crayfish and frog neuromuscular junctions.
1975,
Pubmed
