XB-ART-50947
Nat Rev Mol Cell Biol
2015 Aug 01;168:455-60. doi: 10.1038/nrm4015.
Show Gene links
Show Anatomy links
DNA-protein crosslink repair.
Stingele J
,
Jentsch S
.
???displayArticle.abstract???
DNA-protein crosslinks (DPCs) are highly toxic DNA adducts, but whether dedicated DPC-repair mechanisms exist was until recently unknown. This has changed with discoveries made in yeast and Xenopus laevis that revealed a protease-based DNA-repair pathway specific for DPCs. Importantly, mutations in the gene encoding the putative human homologue of a yeast DPC protease cause a human premature ageing and cancer predisposition syndrome. Thus, DPC repair is a previously overlooked genome-maintenance mechanism that may be essential for tumour suppression.
???displayArticle.pubmedLink??? 26130008
???displayArticle.link??? Nat Rev Mol Cell Biol
References [+] :
Baker,
Nucleotide excision repair eliminates unique DNA-protein cross-links from mammalian cells.
2007, Pubmed
Baker, Nucleotide excision repair eliminates unique DNA-protein cross-links from mammalian cells. 2007, Pubmed
Barker, DNA-protein crosslinks: their induction, repair, and biological consequences. 2005, Pubmed
Basler, Formaldehyde-induced sister chromatid exchanges in vitro and the influence of the exogenous metabolizing systems S9 mix and primary rat hepatocytes. 1985, Pubmed
Cannavo, Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks. 2014, Pubmed
Centore, Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response. 2012, Pubmed
Chen, New mechanistic and functional insights into DNA topoisomerases. 2013, Pubmed
Chválová, Mechanism of the formation of DNA-protein cross-links by antitumor cisplatin. 2007, Pubmed
Davis, DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage. 2012, Pubmed
de Graaf, Cellular pathways for DNA repair and damage tolerance of formaldehyde-induced DNA-protein crosslinks. 2009, Pubmed
Delabaere, The Spartan ortholog maternal haploid is required for paternal chromosome integrity in the Drosophila zygote. 2014, Pubmed
Duxin, Repair of a DNA-protein crosslink by replication-coupled proteolysis. 2014, Pubmed , Xenbase
Fang, DNA-protein crosslinks processed by nucleotide excision repair and homologous recombination with base and strand preference in E. coli model system. 2013, Pubmed
Fornace, Detection of DNA single-strand breaks produced during the repair of damage by DNA-protein cross-linking agents. 1982, Pubmed
Fornace, DNA crosslinking induced by x-rays and chemical agents. 1977, Pubmed
Fu, Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase. 2011, Pubmed , Xenbase
Garaycoechea, Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function. 2012, Pubmed
Ghosal, Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. 2012, Pubmed
Grogan, Formaldehyde-induced mutagenesis in Saccharomyces cerevisiae: molecular properties and the roles of repair and bypass systems. 2012, Pubmed
Hartsuiker, Ctp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions. 2009, Pubmed
Hartsuiker, Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA. 2009, Pubmed
Hoeijmakers, DNA damage, aging, and cancer. 2009, Pubmed
Jackson, The DNA-damage response in human biology and disease. 2009, Pubmed
Juhasz, Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance. 2012, Pubmed
Kiianitsa, A rapid and sensitive assay for DNA-protein covalent complexes in living cells. 2013, Pubmed
Kuo, 5-Azacytidine induced methyltransferase-DNA adducts block DNA replication in vivo. 2007, Pubmed
Langevin, Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice. 2011, Pubmed
Lessel, Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features. 2014, Pubmed
Lu, Structural characterization of formaldehyde-induced cross-links between amino acids and deoxynucleosides and their oligomers. 2010, Pubmed
Machida, Spartan/C1orf124 is important to prevent UV-induced mutagenesis. 2012, Pubmed
Maskey, Spartan deficiency causes genomic instability and progeroid phenotypes. 2014, Pubmed
Nakano, Translocation and stability of replicative DNA helicases upon encountering DNA-protein cross-links. 2013, Pubmed , Xenbase
Nakano, Nucleotide excision repair and homologous recombination systems commit differentially to the repair of DNA-protein crosslinks. 2007, Pubmed
Nakano, Homologous recombination but not nucleotide excision repair plays a pivotal role in tolerance of DNA-protein cross-links in mammalian cells. 2009, Pubmed
Nakano, T7 RNA polymerases backed up by covalently trapped proteins catalyze highly error prone transcription. 2012, Pubmed
Nitiss, Targeting DNA topoisomerase II in cancer chemotherapy. 2009, Pubmed
Novakova, DNA-protein cross-linking by trans-[PtCl(2)(E-iminoether)(2)]. A concept for activation of the trans geometry in platinum antitumor complexes. 2003, Pubmed
Orta, 5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair. 2013, Pubmed
Pommier, Topoisomerase I inhibitors: camptothecins and beyond. 2006, Pubmed
Pommier, Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2). 2014, Pubmed
Pourquier, Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I. 1997, Pubmed
Quievryn, Loss of DNA-protein crosslinks from formaldehyde-exposed cells occurs through spontaneous hydrolysis and an active repair process linked to proteosome function. 2000, Pubmed
Ridpath, Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde. 2007, Pubmed
Rosado, Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway. 2011, Pubmed
Shen, Mechanism and function of oxidative reversal of DNA and RNA methylation. 2014, Pubmed
Shi, Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. 2004, Pubmed
Shoulkamy, Detection of DNA-protein crosslinks (DPCs) by novel direct fluorescence labeling methods: distinct stabilities of aldehyde and radiation-induced DPCs. 2012, Pubmed
Solomon, Mapping protein-DNA interactions in vivo with formaldehyde: evidence that histone H4 is retained on a highly transcribed gene. 1988, Pubmed
Stingele, DNA-protein crosslink repair: proteases as DNA repair enzymes. 2015, Pubmed
Stingele, A DNA-dependent protease involved in DNA-protein crosslink repair. 2014, Pubmed
Swenberg, Endogenous versus exogenous DNA adducts: their role in carcinogenesis, epidemiology, and risk assessment. 2011, Pubmed
Titenko-Holland, Quantification of epithelial cell micronuclei by fluorescence in situ hybridization (FISH) in mortuary science students exposed to formaldehyde. 1996, Pubmed
Trewick, Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. 2002, Pubmed
Tsukada, Histone demethylation by a family of JmjC domain-containing proteins. 2006, Pubmed
Ward, The complexity of DNA damage: relevance to biological consequences. 1994, Pubmed
Yeo, Synthesis of site-specific DNA-protein conjugates and their effects on DNA replication. 2014, Pubmed
Zhang, Radiation-induced DNA damage in tumors and normal tissues. III. Oxygen dependence of the formation of strand breaks and DNA-protein crosslinks. 1995, Pubmed