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Mol Cell Biol
1994 May 01;145:3115-29. doi: 10.1128/mcb.14.5.3115-3129.1994.
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A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription.
Grépin C
,
Dagnino L
,
Robitaille L
,
Haberstroh L
,
Antakly T
,
Nemer M
.
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In contrast to skeletal muscle, the mechanisms responsible for activation and maintenance of tissue-specific transcription in cardiac muscle remain poorly understood. A family of hormone-encoding genes is expressed in a highly specific manner in cardiac but not skeletal myocytes. This includes the A- and B-type natriuretic peptide (ANP and BNP) genes, which encode peptide hormones with crucial roles in the regulation of blood volume and pressure. Since these genes are markers of cardiac cells, we have used them to probe the mechanisms for cardiac muscle-specific transcription. Cloning and functional analysis of the rat BNP upstream sequences revealed unexpected structural resemblance to erythroid but not to muscle-specific promoters and enhancers, including a requirement for regulatory elements containing GATA motifs. A cDNA clone corresponding to a member of the GATA family of transcription factors was isolated from a cardiomyocyte cDNA library. Transcription of this GATA gene is restricted mostly to the heart and is undetectable in skeletal muscle. Within the heart, GATA transcripts are localized in ANP- and BNP-expressing myocytes, and forced expression of the GATA protein in heterologous cells markedly activates transcription from the natural cardiac muscle-specific ANP and BNP promoters. This GATA-dependent pathway defines the first mechanism for cardiac muscle-specific transcription. Moreover, the present findings reveal striking similarities between the mechanisms controlling gene expression in hematopoietic and cardiac cells and may have important implications for studies of cardiogenesis.
Amacher,
Multiple regulatory elements contribute differentially to muscle creatine kinase enhancer activity in skeletal and cardiac muscle.
1993, Pubmed
Amacher,
Multiple regulatory elements contribute differentially to muscle creatine kinase enhancer activity in skeletal and cardiac muscle.
1993,
Pubmed
Andrews,
Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein.
1993,
Pubmed
Antakly,
Demonstration of the intracellular localization and up-regulation of glucocorticoid receptor by in situ hybridization and immunocytochemistry.
1989,
Pubmed
Antakly,
Induced expression of the glucocorticoid receptor in the rat intermediate pituitary lobe.
1985,
Pubmed
Arceci,
Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.
1993,
Pubmed
Ardati,
A nuclear pathway for alpha 1-adrenergic receptor signaling in cardiac cells.
1993,
Pubmed
Argentin,
Developmental stage-specific regulation of atrial natriuretic factor gene transcription in cardiac cells.
1994,
Pubmed
Argentin,
Distal cis-acting promoter sequences mediate glucocorticoid stimulation of cardiac atrial natriuretic factor gene transcription.
1991,
Pubmed
Argentin,
The gene for rat atrial natriuretic factor.
1985,
Pubmed
Barton,
The myosin alkali light chain proteins and their genes.
1985,
Pubmed
Bloch,
Neonatal atria and ventricles secrete atrial natriuretic factor via tissue-specific secretory pathways.
1986,
Pubmed
Braun,
Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death.
1992,
Pubmed
Chapeau,
Localization of immunoreactive synthetic atrial natriuretic factor (ANF) in the heart of various animal species.
1985,
Pubmed
Chomczynski,
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
1987,
Pubmed
Dagnino,
Increased transcripts for B-type natriuretic peptide in spontaneously hypertensive rats. Quantitative polymerase chain reaction for atrial and brain natriuretic peptide transcripts.
1992,
Pubmed
Dagnino,
Differential expression of natriuretic peptide genes in cardiac and extracardiac tissues.
1991,
Pubmed
de Bold,
Atrial natriuretic factor: a hormone produced by the heart.
1985,
Pubmed
Donald,
Immunohistochemical localisation of natriuretic peptides in the heart and brain of the gulf toadfish Opsanus beta.
1992,
Pubmed
Emerson,
Erythroid-specific activation and derepression of the chick beta-globin promoter in vitro.
1989,
Pubmed
Evans,
The erythroid-specific transcription factor Eryf1: a new finger protein.
1989,
Pubmed
Evans,
trans-Activation of a globin promoter in nonerythroid cells.
1991,
Pubmed
Evans,
An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes.
1988,
Pubmed
Fong,
The erythroid-specific protein cGATA-1 mediates distal enhancer activity through a specialized beta-globin TATA box.
1992,
Pubmed
Gossett,
A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.
1989,
Pubmed
Hasty,
Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene.
1993,
Pubmed
Ho,
Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.
1991,
Pubmed
Ito,
Erythroid transcription factor GATA-1 is abundantly transcribed in mouse testis.
1993,
Pubmed
Joulin,
A T-cell specific TCR delta DNA binding protein is a member of the human GATA family.
1991,
Pubmed
Kelley,
GATA-4 is a novel transcription factor expressed in endocardium of the developing heart.
1993,
Pubmed
,
Xenbase
Keynes,
Mechanisms of vertebrate segmentation.
1988,
Pubmed
Ko,
Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.
1991,
Pubmed
Lee,
Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells.
1991,
Pubmed
Linask,
Precardiac cell migration: fibronectin localization at mesoderm-endoderm interface during directional movement.
1986,
Pubmed
McBride,
fos/jun repression of cardiac-specific transcription in quiescent and growth-stimulated myocytes is targeted at a tissue-specific cis element.
1993,
Pubmed
Miller,
A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins.
1993,
Pubmed
Minty,
Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily conserved repeated motif.
1986,
Pubmed
Nakatsuji,
A single MEF-2 site is a major positive regulatory element required for transcription of the muscle-specific subunit of the human phosphoglycerate mutase gene in skeletal and cardiac muscle cells.
1992,
Pubmed
Navankasattusas,
A ubiquitous factor (HF-1a) and a distinct muscle factor (HF-1b/MEF-2) form an E-box-independent pathway for cardiac muscle gene expression.
1992,
Pubmed
Needleman,
The biochemical pharmacology of atrial peptides.
1989,
Pubmed
Nemer,
Gene structure of human cardiac hormone precursor, pronatriodilatin.
,
Pubmed
Nemer,
Expression of atrial natriuretic factor gene in heart ventricular tissue.
1986,
Pubmed
Netchitailo,
Localization and characterization of atrial natriuretic factor (ANF)-like peptide in the frog atrium.
1986,
Pubmed
Ogawa,
Natriuretic peptides as cardiac hormones in normotensive and spontaneously hypertensive rats. The ventricle is a major site of synthesis and secretion of brain natriuretic peptide.
1991,
Pubmed
Olson,
MyoD family: a paradigm for development?
1990,
Pubmed
Pevny,
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1.
1991,
Pubmed
Plumb,
GATAAG; a cis-control region binding an erythroid-specific nuclear factor with a role in globin and non-globin gene expression.
1989,
Pubmed
Pollock,
Human SRF-related proteins: DNA-binding properties and potential regulatory targets.
1991,
Pubmed
Rudnicki,
Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development.
1992,
Pubmed
Sassoon,
Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis.
1989,
Pubmed
Schreiber,
Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells.
1989,
Pubmed
Seidman,
Nucleotide sequences of the human and mouse atrial natriuretic factor genes.
1984,
Pubmed
Sudoh,
A new natriuretic peptide in porcine brain.
1988,
Pubmed
Suzuki,
Cellular mechanisms for synthesis and secretion of atrial natriuretic peptide and brain natriuretic peptide in cultured rat atrial cells.
1992,
Pubmed
Takei,
Amino acid sequence and relative biological activity of eel atrial natriuretic peptide.
1989,
Pubmed
Tanaka,
Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation.
1990,
Pubmed
Thibault,
Rat brain natriuretic peptide is localized in atrial granules and released into the circulation.
1992,
Pubmed
Toshimori,
Chicken atrial natriuretic peptide (chANP) and its secretion.
1990,
Pubmed
Tsai,
Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells.
1989,
Pubmed
Vandekerckhove,
Simultaneous expression of skeletal muscle and heart actin proteins in various striated muscle tissues and cells. A quantitative determination of the two actin isoforms.
1986,
Pubmed
Vesely,
The most primitive heart in the animal kingdom contains the atrial natriuretic peptide hormonal system.
1992,
Pubmed
Vlasuk,
Structure and analysis of the bovine atrial natriuretic peptide precursor gene.
1986,
Pubmed
Walters,
Functional erythroid promoters created by interaction of the transcription factor GATA-1 with CACCC and AP-1/NFE-2 elements.
1992,
Pubmed
Weintraub,
The myoD gene family: nodal point during specification of the muscle cell lineage.
1991,
Pubmed
Wilson,
A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells.
1990,
Pubmed
Yamamoto,
Activity and tissue-specific expression of the transcription factor NF-E1 multigene family.
1990,
Pubmed
Yang,
Distinct roles for the two cGATA-1 finger domains.
1992,
Pubmed
Yu,
Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors.
1992,
Pubmed
Yu,
The CACC box upstream of human embryonic epsilon globin gene binds Sp1 and is a functional promoter element in vitro and in vivo.
1991,
Pubmed
Zeller,
Localized expression of the atrial natriuretic factor gene during cardiac embryogenesis.
1987,
Pubmed
