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The Bambi (Bmp and activin membrane-bound inhibitor) gene encodes a transmembrane protein highly similar in amino acid sequence to transforming growth factor-beta (TGF-beta receptors, however, the Bambi intracellular domain is short and lacks a serine/threonine-kinase domain that is essential for transducing TGF beta signaling. Previous biochemical assays showed that Bambi interacts directly with BMP receptors and antagonizes BMP signaling. Interestingly, the expression of Bambi largely overlaps, both temporally and spatially, with that of Bmp4 during early embryonic development in Xenopus, zebrafish, and mice, which led to the hypothesis that Bambi may function to regulate BMP signaling during embryogenesis. To directly analyze the roles of Bambi during embryonic development, we generated mice carrying a conditional allele of Bambi, Bambi(flox), with loxP sequences flanking the first exon that encodes the N-terminus and signal peptide region of the Bambi protein. Mice homozygous for this targeted conditional allele appear normal and fertile. We crossed the Bambi(flox)/+ mice to the EIIa-Cre transgenic mice and generated mice carrying deletion of the first exon of the Bambi gene. Surprisingly, mice homozygous for the deleted allele were viable, fertile and did not exhibit any discernible developmental defect. Our data exclude an essential role for Bambi in mouse embryonic development and postnatal survival.
Bachiller,
The organizer factors Chordin and Noggin are required for mouse forebrain development.
2000, Pubmed
Bachiller,
The organizer factors Chordin and Noggin are required for mouse forebrain development.
2000,
Pubmed
Bachiller,
The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome.
2003,
Pubmed
Balemans,
Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators.
2002,
Pubmed
,
Xenbase
Brunet,
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton.
1998,
Pubmed
Degen,
Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts.
1996,
Pubmed
Dunn,
Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4.
1997,
Pubmed
,
Xenbase
Dupé,
In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE).
1997,
Pubmed
Grotewold,
Bambi is coexpressed with Bmp-4 during mouse embryogenesis.
2001,
Pubmed
,
Xenbase
Lakso,
Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.
1996,
Pubmed
Loveland,
Expression of Bambi is widespread in juvenile and adult rat tissues and is regulated in male germ cells.
2003,
Pubmed
Martin,
The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages.
1995,
Pubmed
McMahon,
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.
1998,
Pubmed
Nohe,
Signal transduction of bone morphogenetic protein receptors.
2004,
Pubmed
Onichtchouk,
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
1999,
Pubmed
,
Xenbase
Shi,
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
2003,
Pubmed
Swiatek,
Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20.
1993,
Pubmed
Tsang,
Zebrafish nma is involved in TGFbeta family signaling.
2000,
Pubmed
,
Xenbase
Winnier,
Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.
1995,
Pubmed
