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XB-ART-21171
Dev Biol 1994 Jun 01;1632:521-4. doi: 10.1006/dbio.1994.1168.
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MAP kinase is activated during mesoderm induction in Xenopus laevis.

Hartley RS , Lewellyn AL , Maller JL .


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MAP kinase (MAPK) is activated in animal cap explants from Xenopus embryos in response to mesoderm induction by FGF. This activation is rapid, appearing within 1 min of treatment with FGF, and prolonged, lasting for at least 2 hr. By immunoblot analysis, this activation of MAPK is coupled with an electrophoretic shift to the slowly migrating, phosphorylated form of MAPK. Activin-stimulated mesoderm induction also results in the activation of MAPK, but only upon prolonged exposure. However, activin can potentiate the activation of MAPK by FGF as early as 1 min after administration. These findings suggest that MAPK is involved in the early signaling events of FGF-mediated mesoderm induction, and this involvement is modulated by other mesoderm inducers such as activin.

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Species referenced: Xenopus laevis
Genes referenced: mapk1