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The mechanisms by which transforming growth factor beta (TGF-beta) and related ligands regulate transcription remain poorly understood. The winged-helix (WH) transcription factor fork head activin signal transducer 1 (FAST-1) was identified as a mediator of activin signaling in Xenopus embryos (X. Chen, M. J. Rubock, and M. Whitman, Nature 383:691-696, 1996). We have cloned a novel WH gene from the mouse which shares many properties with FAST-1. We find that this gene, which we call FAST-2, is able to mediate transcriptional activation by TGF-beta. FAST-2 also interacts directly with Smad2, a cytoplasmic protein which is translocated to the nucleus in response to TGF-beta, and forms a multimeric complex with Smad2 and Smad4 on the activin response element, a high-affinity binding site for FAST-1. Analysis of the sequences of FAST-1 and FAST-2 reveals substantial protein sequence divergence compared to known vertebrate orthologs in the WH family. This suggests that FAST-2 represents a new WH gene related to FAST-1, which functions to mediate TGF-beta signals in mammals. We have also examined the structure of the FAST-2 gene and find that it overlaps with a kinesin motor protein gene. The genes are transcribed in opposite orientations, and their transcripts overlap in the 3' untranslated region.
Ang,
HNF-3 beta is essential for node and notochord formation in mouse development.
1994, Pubmed
Ang,
HNF-3 beta is essential for node and notochord formation in mouse development.
1994,
Pubmed
Brissette,
The product of the mouse nude locus, Whn, regulates the balance between epithelial cell growth and differentiation.
1996,
Pubmed
Bristow,
Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B.
1993,
Pubmed
Chen,
A transcriptional partner for MAD proteins in TGF-beta signalling.
1996,
Pubmed
,
Xenbase
Chen,
Smad4 and FAST-1 in the assembly of activin-responsive factor.
1997,
Pubmed
,
Xenbase
Clark,
Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5.
1993,
Pubmed
Dou,
TWH regulates the development of subsets of spinal cord neurons.
1997,
Pubmed
Frohman,
Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.
1988,
Pubmed
Hanlon,
Characterization of KIFC2, a neuronal kinesin superfamily member in mouse.
1997,
Pubmed
Hatini,
Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2.
1996,
Pubmed
Huang,
Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo.
1995,
Pubmed
,
Xenbase
Kaufmann,
Five years on the wings of fork head.
1996,
Pubmed
Kume,
The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus.
1998,
Pubmed
Labbé,
Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2.
1998,
Pubmed
,
Xenbase
Labosky,
The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex.
1997,
Pubmed
Lai,
Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function.
1993,
Pubmed
Li,
Characterization of the structure and function of the gene for transcription factor BF-1, an essential regulator of forebrain development.
1996,
Pubmed
Liu,
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.
1997,
Pubmed
,
Xenbase
Massaous,
TGF-beta signalling through the Smad pathway.
1997,
Pubmed
Miyajima,
Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus.
1989,
Pubmed
Saito,
KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles.
1997,
Pubmed
Sussman,
Short-term, high-efficiency expression of transfected DNA.
1984,
Pubmed
Weinstein,
The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo.
1994,
Pubmed
Winnier,
The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo.
1997,
Pubmed
Xuan,
Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres.
1995,
Pubmed
Zhou,
Characterization of human FAST-1, a TGF beta and activin signal transducer.
1998,
Pubmed
,
Xenbase
