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We have cloned Xenopus orthologues of the Drosophila planar cell polarity (PCP) gene Prickle. Xenopus Prickle (XPk) is expressed in tissues at the dorsal midline during gastrulation and early neurulation. XPk is later expressed in a segmental pattern in the presomitic mesoderm and then in recently formed somites. XPk is also expressed in the tailbud, pronephric duct, retina, and the otic vesicle. The complex expression pattern of XPk suggests that PCP signaling is used in a diverse array of developmental processes in vertebrate embryos.
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12128221
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prickle1 (prickle homolog 1) gene expression in Xenopus laevis embryos, NF stage 10.25, as assayed by in situ hybridization, vegetal view.
prickle1 (prickle homolog 1) gene expression in Xenopus laevis embryos, NF stage 32, as assayed by in situ hybridization, lateral view, anteriorleft, dorsal up.
prickle1 (prickle homolog 1) gene expression in Xenopus laevis embryos, NF stage 30, as assayed by in situ hybridization. Lateral view: anteriorleft, dorsal up.
prickle1 (prickle homolog 1) gene expression in Xenopus laevis embryos, NF stage 26, as assayed by in situ hybridization, lateral view: anteriorleft, dorsal up.
prickle1 (prickle homolog 1) gene expression in Xenopus laevis embryos, NF stage 17, as assayed by in situ hybridization, dorsal view, anteriorleft.
prickle1 (prickle homolog 1) gene expression in Xenopus laevis embryos, NF stage 12, as assayed by in situ hybridization, posterior-dorsal view.
prickle1 (prickle homolog 1) gene expression in Xenopus laevis embryos, NF stage 10.5, as assayed by in situ hybridization, vegetal view.
Fig. 2. Early expression of XPk. (A–C) Vegetal view, dorsal at top. (A) st. 10+. (B) st. 10.5. (C) st. 11.5. (D) Sagittal section of st. 11.5, dorsal to right; arrowhead indicates weakening expression in mesoderm, arrow indicates strong expression in posterior neural ectoderm (PNE); ANE=anterior neural ectoderm. (E) Dorsal view, anterior at top. st 12. (F) Cleared embryo st. 13; sagittal view, anterior to left. AR=archenteron.
Fig. 3. Later expression of XPk. (A) st. 17, dorsal view, anterior to left. (a′) Transverse section though stage 17 embryo. (B) st 26. (C–D) St. 30; sagittal view, anterior to left. (D) Cleared embryo. PND=pronephric duct; SOM=forming somites; NC=notochord; TB=tailbud; FP=floorplate (d1–d3). Transverse sections at leveles indicated by lines in panel (D). (E) Head of stage 32 embryo. OV=otic vesicle. (e′) Section through eye, st. 32.
