Dev Growth Differ 1989 Dec 01;316:531-541. doi: 10.1111/j.1440-169X.1989.00531.x.

Marked Alteration at Midblastula Transition in the Effect of Lithium on Formation of the Larval Body Pattern of Xenopus laevis: (midblastula transition/LiCl/pattern formation/half-egg fragment/Xenopus laevis).

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Embryos of Xenopus laevis were exposed to 0.4 M LiCl for 5 min at various stages of development. The effect of lithium on the larval body pattern could be detected from the 2-cell to the late gastrula stage, but changed from reduction of posterior structures ("anteriorization") to reduction of anterior structures ("posteriorization") just after the 12th cleavage, the time of midblastula transition (MBT). Temporal coincidence of MBT with alteration of the effect of lithium was observed even with embryos derived from half-egg fragment, in which MBT occurs just after the 11th cleavage. These results suggest the existence of a mechanism for formation of the basic plan of the larval body whose function changes at MBT. Combinations of the pre- and post-MBT exposures to lithium induced marked posteriorization in most larvae, indicating that the basic plan is not irreversibly determined until MBT, but is fixed during post-MBT stages.

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