XB-ART-46890
Semin Cell Dev Biol
2013 May 01;245:480-9. doi: 10.1016/j.semcdb.2013.03.008.
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Wnt signaling during cochlear development.
Munnamalai V
,
Fekete DM
.
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Wnt signaling is a hallmark of all embryonic development with multiple roles at multiple developmental time points. Wnt signaling is also important in the development of several organs, one of which is the inner ear, where it participates in otic specification, the formation of vestibular structures, and the development of the cochlea. In particular, we focus on Wnt signaling in the auditory organ, the cochlea. Attempting to dissect the multiple Wnt signaling pathways in the mammalian cochlea is a challenging task due to limited expression data, particularly at proliferating stages. To offer predictions about Wnt activity, we compare cochlear development with that of other biological systems such as Xenopus retina, brain, cancer cells and osteoblasts. Wnts are likely to regulate development through crosstalk with other signaling pathways, particularly Notch and FGF, leading to changes in the expression of Sox2 and proneural (pro-hair cell) genes. In this review we have consolidated the known signaling pathways in the cochlea with known developmental roles of Wnts from other systems to generate a potential timeline of cochlear development.
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Species referenced: Xenopus
Genes referenced: notch1 sox2
References [+] :
Agathocleous,
A directional Wnt/beta-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina.
2009, Pubmed,
Xenbase
Agathocleous, A directional Wnt/beta-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina. 2009, Pubmed , Xenbase
Alvarez, Requirements for FGF3 and FGF10 during inner ear formation. 2003, Pubmed , Xenbase
Aman, Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression. 2008, Pubmed
Bermingham-McDonogh, Expression of Prox1 during mouse cochlear development. 2006, Pubmed
Bernard, Wnt4 inhibits beta-catenin/TCF signalling by redirecting beta-catenin to the cell membrane. 2008, Pubmed
Berndt, Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling. 2011, Pubmed
Blanton, A novel locus for autosomal dominant non-syndromic deafness (DFNA41) maps to chromosome 12q24-qter. 2002, Pubmed
Bok, Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear. 2005, Pubmed
Bordonaro, A switch from canonical to noncanonical Wnt signaling mediates drug resistance in colon cancer cells. 2011, Pubmed
Brooker, Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. 2006, Pubmed
Bylund, Vertebrate neurogenesis is counteracted by Sox1-3 activity. 2003, Pubmed
Chai, Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea. 2011, Pubmed
Chai, Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. 2012, Pubmed
Chamorro, FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. 2005, Pubmed , Xenbase
Chen, Jagged1 expression regulated by Notch3 and Wnt/β-catenin signaling pathways in ovarian cancer. 2010, Pubmed
Chen, p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti. 1999, Pubmed
Chien, A Wnt survival guide: from flies to human disease. 2009, Pubmed
Dabdoub, Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea. 2008, Pubmed
Dabdoub, Planar cell polarity and a potential role for a Wnt morphogen gradient in stereociliary bundle orientation in the mammalian inner ear. 2005, Pubmed
Dabdoub, Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea. 2003, Pubmed
de Lau, Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. 2011, Pubmed
Denayer, Canonical Wnt signaling controls proliferation of retinal stem/progenitor cells in postembryonic Xenopus eyes. 2008, Pubmed , Xenbase
Ehm, RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus. 2010, Pubmed
Fantetti, Wnts and Wnt inhibitors do not influence axon outgrowth from chicken statoacoustic ganglion neurons. 2011, Pubmed
Ferrer-Vaquer, A sensitive and bright single-cell resolution live imaging reporter of Wnt/ß-catenin signaling in the mouse. 2010, Pubmed
Fre, Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. 2009, Pubmed
Goodrich, Principles of planar polarity in animal development. 2011, Pubmed
Graham, SOX2 functions to maintain neural progenitor identity. 2003, Pubmed
Groves, Shaping sound in space: the regulation of inner ear patterning. 2012, Pubmed
Hartman, Notch signaling specifies prosensory domains via lateral induction in the developing mammalian inner ear. 2010, Pubmed
Hayashi, Fgf20 is required for sensory epithelial specification in the developing cochlea. 2008, Pubmed
Hayashi, Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea. 2008, Pubmed
Hemond, Formation of the cochlea in the chicken embryo: sequence of innervation and localization of basal lamina-associated molecules. 1991, Pubmed
Jacques, A dual function for canonical Wnt/β-catenin signaling in the developing mammalian cochlea. 2012, Pubmed
Jayasena, Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode. 2008, Pubmed
Kageyama, Roles of Hes genes in neural development. 2008, Pubmed
Kan, Sox1 acts through multiple independent pathways to promote neurogenesis. 2004, Pubmed
Kiernan, The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear. 2006, Pubmed
Kirjavainen, Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia. 2008, Pubmed
Kopp, Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cells. 2008, Pubmed
Kubo, Wnt2b controls retinal cell differentiation at the ciliary marginal zone. 2003, Pubmed
Kubo, Wnt2b inhibits differentiation of retinal progenitor cells in the absence of Notch activity by downregulating the expression of proneural genes. 2005, Pubmed
Ladher, From shared lineage to distinct functions: the development of the inner ear and epibranchial placodes. 2010, Pubmed
Ladher, Identification of synergistic signals initiating inner ear development. 2000, Pubmed
Ladher, FGF8 initiates inner ear induction in chick and mouse. 2005, Pubmed
Lin, Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling. 2005, Pubmed
Louvi, Notch signalling in vertebrate neural development. 2006, Pubmed
Macheda, The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling. 2012, Pubmed
Mansukhani, Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. 2005, Pubmed
Masiakowski, A novel family of cell surface receptors with tyrosine kinase-like domain. 1992, Pubmed
Mikels, Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. 2006, Pubmed
Munnamalai, Notch prosensory effects in the Mammalian cochlea are partially mediated by Fgf20. 2012, Pubmed
Neves, The prosensory function of Sox2 in the chicken inner ear relies on the direct regulation of Atoh1. 2012, Pubmed
Nusse, Wnt signaling. 2012, Pubmed
Ohyama, BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. 2010, Pubmed
Ohyama, Wnt signals mediate a fate decision between otic placode and epidermis. 2006, Pubmed
Osakada, Wnt signaling promotes regeneration in the retina of adult mammals. 2007, Pubmed
Pan, Notch signaling is required for the generation of hair cells and supporting cells in the mammalian inner ear. 2010, Pubmed
Parr, Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. 1993, Pubmed
Petersen, Wnt signaling and the polarity of the primary body axis. 2009, Pubmed
Qian, Wnt5a functions in planar cell polarity regulation in mice. 2007, Pubmed , Xenbase
Que, Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. 2007, Pubmed
Rehm, Vascular defects and sensorineural deafness in a mouse model of Norrie disease. 2002, Pubmed
Riccomagno, Specification of the mammalian cochlea is dependent on Sonic hedgehog. 2002, Pubmed
Riccomagno, Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh. 2005, Pubmed
Rodilla, Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. 2009, Pubmed
Ruben, Development of the inner ear of the mouse: a radioautographic study of terminal mitoses. 1967, Pubmed
Schuijers, Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins. 2012, Pubmed
Shi, Beta-catenin up-regulates Atoh1 expression in neural progenitor cells by interaction with an Atoh1 3' enhancer. 2010, Pubmed
Shi, Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea. 2012, Pubmed
Sienknecht, Comprehensive Wnt-related gene expression during cochlear duct development in chicken. 2008, Pubmed
Sienknecht, Mapping of Wnt, frizzled, and Wnt inhibitor gene expression domains in the avian otic primordium. 2009, Pubmed
Stevens, Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner ear. 2003, Pubmed
Stoick-Cooper, Distinct Wnt signaling pathways have opposing roles in appendage regeneration. 2007, Pubmed
van Amerongen, Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development. 2012, Pubmed
van Amerongen, Towards an integrated view of Wnt signaling in development. 2009, Pubmed
Van Raay, Frizzled 5 signaling governs the neural potential of progenitors in the developing Xenopus retina. 2005, Pubmed , Xenbase
Wallingford, Planar cell polarity and the developmental control of cell behavior in vertebrate embryos. 2012, Pubmed
Wang, Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx. 2004, Pubmed
Wang, The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. 2006, Pubmed
Wang, Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene. 2001, Pubmed
Whitehead, The growth of cochlear fibers and the formation of their synaptic endings in the avian inner ear: a study with the electron microscope. 1985, Pubmed
Wright, Fgf3 and Fgf10 are required for mouse otic placode induction. 2003, Pubmed
Xu, Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. 2004, Pubmed
Yamaguchi, Histone deacetylase 1 regulates retinal neurogenesis in zebrafish by suppressing Wnt and Notch signaling pathways. 2005, Pubmed
Yamamoto, Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. 2008, Pubmed
Yamamoto, Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2. 2007, Pubmed
Ye, Expression of the Norrie disease gene (Ndp) in developing and adult mouse eye, ear, and brain. 2011, Pubmed
Yu, Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes. 2010, Pubmed
Zorn, Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin. 1999, Pubmed , Xenbase
Zou, Morphogens as conserved axon guidance cues. 2007, Pubmed