Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-17545
Science 1996 Oct 25;2745287:614-7.
Show Gene links Show Anatomy links

An asymmetric model for the nucleosome: a binding site for linker histones inside the DNA gyres.

Pruss D , Bartholomew B , Persinger J , Hayes J , Arents G , Moudrianakis EN , Wolffe AP .


???displayArticle.abstract???
Histone-DNA contacts within a nucleosome influence the function of trans-acting factors and the molecular machines required to activate the transcription process. The internal architecture of a positioned nucleosome has now been probed with the use of photoactivatable cross-linking reagents to determine the placement of histones along the DNA molecule. A model for the nucleosome is proposed in which the winged-helix domain of the linker histone is asymmetrically located inside the gyres of DNA that also wrap around the core histones. This domain extends the path of the protein superhelix to one side of the core particle.

???displayArticle.pubmedLink??? 8849453
???displayArticle.link??? Science



References :
Pennisi, Linker histones, DNA's protein custodians, gain new respect. 1996, Pubmed, Xenbase