Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
Several DEG/ENaC cation channel subunits are expressed in the tongue and in cutaneous sensory neurons, where they are postulated to function as receptors for salt and sour taste and for touch. Because these tissues are exposed to large temperature variations, we examined how temperature affects DEG/ENaC channel function. We found that cold temperature markedly increased the constitutively active Na(+) currents generated by epithelial Na(+) channels (ENaC). Half-maximal stimulation occurred at 25 degrees C. Cold temperature did not induce current from other DEG/ENaC family members (BNC1, ASIC, and DRASIC). However, when these channels were activated by acid, cold temperature potentiated the currents by slowing the rate of desensitization. Potentiation was abolished by a "Deg" mutation that alters channel gating. Temperature changes in the physiologic range had prominent effects on current in cells heterologously expressing acid-gated DEG/ENaC channels, as well as in dorsal root ganglion sensory neurons. The finding that cold temperature modulates DEG/ENaC channel function may provide a molecular explanation for the widely recognized ability of temperature to modify taste sensation and mechanosensation.
Adair,
A model of the detection of warmth and cold by cutaneous sensors through effects on voltage-gated membrane channels.
1999, Pubmed
Adair,
A model of the detection of warmth and cold by cutaneous sensors through effects on voltage-gated membrane channels.
1999,
Pubmed
Adams,
Protons activate brain Na+ channel 1 by inducing a conformational change that exposes a residue associated with neurodegeneration.
1998,
Pubmed
,
Xenbase
Askwith,
Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels.
2000,
Pubmed
,
Xenbase
Benos,
Structure and function of amiloride-sensitive Na+ channels.
1995,
Pubmed
Benson,
Acid-evoked currents in cardiac sensory neurons: A possible mediator of myocardial ischemic sensation.
1999,
Pubmed
Boughter,
From channels to behavior: an integrative model of NaCl taste.
1999,
Pubmed
Boulant,
Temperature receptors in the central nervous system.
1986,
Pubmed
Canessa,
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits.
1994,
Pubmed
,
Xenbase
Caterina,
The capsaicin receptor: a heat-activated ion channel in the pain pathway.
1997,
Pubmed
,
Xenbase
Caterina,
A capsaicin-receptor homologue with a high threshold for noxious heat.
1999,
Pubmed
,
Xenbase
Cruz,
Thermal stimulation of taste.
2000,
Pubmed
Drummond,
Localization of beta and gamma subunits of ENaC in sensory nerve endings in the rat foot pad.
2000,
Pubmed
Fricke,
Epithelial Na+ channels and stomatin are expressed in rat trigeminal mechanosensory neurons.
2000,
Pubmed
García-Añoveros,
BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels.
1997,
Pubmed
García-Añoveros,
The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations.
1998,
Pubmed
,
Xenbase
Garty,
Epithelial sodium channels: function, structure, and regulation.
1997,
Pubmed
Green,
The effect of cooling on the perception of carbohydrate and intensive sweeteners.
1988,
Pubmed
Iggo,
The structure and function of a slowly adapting touch corpuscle in hairy skin.
1969,
Pubmed
Kuismanen,
Low temperature-induced transport blocks as tools to manipulate membrane traffic.
1989,
Pubmed
Li,
Expression and localization of amiloride-sensitive sodium channel indicate a role for non-taste cells in taste perception.
1994,
Pubmed
Lin,
Epithelial Na+ channel subunits in rat taste cells: localization and regulation by aldosterone.
1999,
Pubmed
Lingueglia,
A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells.
1997,
Pubmed
Lingueglia,
Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel.
1995,
Pubmed
,
Xenbase
Mano,
DEG/ENaC channels: a touchy superfamily that watches its salt.
1999,
Pubmed
Mazzoleni,
Conductivity values of tissue culture medium from 20 degrees C to 40 degrees C.
1986,
Pubmed
McBurney,
Temperature dependence of human taste responses.
1973,
Pubmed
McDonald,
Cloning, expression, and tissue distribution of a human amiloride-sensitive Na+ channel.
1994,
Pubmed
,
Xenbase
McDonald,
Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel.
1995,
Pubmed
,
Xenbase
Price,
Cloning and expression of a novel human brain Na+ channel.
1996,
Pubmed
,
Xenbase
Price,
The mammalian sodium channel BNC1 is required for normal touch sensation.
2000,
Pubmed
Snyder,
Gating induces a conformational change in the outer vestibule of ENaC.
2000,
Pubmed
,
Xenbase
Snyder,
Electrophysiological and biochemical evidence that DEG/ENaC cation channels are composed of nine subunits.
1998,
Pubmed
,
Xenbase
Spray,
Cutaneous temperature receptors.
1986,
Pubmed
Sutherland,
Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons.
2001,
Pubmed
Tavernarakis,
Molecular modeling of mechanotransduction in the nematode Caenorhabditis elegans.
1997,
Pubmed
Ugawa,
Receptor that leaves a sour taste in the mouth.
1998,
Pubmed
,
Xenbase
Waldmann,
H(+)-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels.
1998,
Pubmed
Waldmann,
The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans.
1996,
Pubmed
Waldmann,
A proton-gated cation channel involved in acid-sensing.
1997,
Pubmed
,
Xenbase
Waldmann,
Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons.
1997,
Pubmed
