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Figure 1. . Model of inward rectification. Structural model of the closed KirBac1.1 channel, outlining the transmembrane and cytoplasmic pore regions. For comparison with channel pore dimensions, DA4, DA9, DA12, and spermine (SPM) are shown from left to right as space filling molecules. Relative distances (in angstroms) between the selectivity filter (SF), D172, and E224/E229 in Kir2.1 are assumed to be the same as between the corresponding positions in KirBac1.1.
Chang,
The effects of spermine on the accessibility of residues in the M2 segment of Kir2.1 channels expressed in Xenopus oocytes.
2003, Pubmed,
Xenbase
Chang,
The effects of spermine on the accessibility of residues in the M2 segment of Kir2.1 channels expressed in Xenopus oocytes.
2003,
Pubmed
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Xenbase
Dibb,
Molecular basis of ion selectivity, block, and rectification of the inward rectifier Kir3.1/Kir3.4 K(+) channel.
2003,
Pubmed
Guo,
Interaction mechanisms between polyamines and IRK1 inward rectifier K+ channels.
2003,
Pubmed
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Xenbase
Guo,
Mechanism of rectification in inward-rectifier K+ channels.
2003,
Pubmed
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Xenbase
Ishihara,
Two modes of polyamine block regulating the cardiac inward rectifier K+ current IK1 as revealed by a study of the Kir2.1 channel expressed in a human cell line.
2004,
Pubmed
Kubo,
Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channel.
2001,
Pubmed
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Xenbase
Kuo,
Crystal structure of the potassium channel KirBac1.1 in the closed state.
2003,
Pubmed
Pearson,
Block of the Kir2.1 channel pore by alkylamine analogues of endogenous polyamines.
1998,
Pubmed
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Xenbase
Phillips,
Ligand-induced closure of inward rectifier Kir6.2 channels traps spermine in the pore.
2003,
Pubmed
Stanfield,
Spermine is fit to block inward rectifier (Kir) channels.
2003,
Pubmed
Xie,
Spermine block of the strong inward rectifier potassium channel Kir2.1: dual roles of surface charge screening and pore block.
2002,
Pubmed
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Xenbase
Xie,
Inward rectification by polyamines in mouse Kir2.1 channels: synergy between blocking components.
2003,
Pubmed
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Xenbase
