Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Nat Neurosci
2002 Aug 01;58:721-2. doi: 10.1038/nn888.
Show Gene links
Show Anatomy links
Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol.
Sundstrom-Poromaa I
,
Smith DH
,
Gong QH
,
Sabado TN
,
Li X
,
Light A
,
Wiedmann M
,
Williams K
,
Smith SS
.
???displayArticle.abstract???
Here we report that low concentrations of alcohol (1-3 mM) increased Cl(-) currents gated by a recombinant GABA(A) receptor, alpha(4)beta(2)delta, by 40-50% in Xenopus laevis oocytes. We also found greater hippocampal expression of receptors containing alpha(4) and delta subunits, using a rat model of premenstrual syndrome (PMS) in which 1-3 mM alcohol preferentially enhanced GABA-gated currents, and low doses of alcohol attenuated anxiety and behavioral reactivity. The alcohol sensitivity of delta-containing receptors may underlie the reinforcing effects of alcohol during PMS, when eye saccade responses to low doses of alcohol are increased.
Adkins,
alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential.
2001, Pubmed
Adkins,
alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential.
2001,
Pubmed
Brickley,
Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance.
2001,
Pubmed
Cohen,
The effects of ethanol on EEG activity in males at risk for alcoholism.
1993,
Pubmed
Holford,
Clinical pharmacokinetics of ethanol.
1987,
Pubmed
Kalant,
Sensorimotor and physiological effects of various alcoholic beverages.
1975,
Pubmed
Koob,
Picrotoxinin receptor ligand blocks anti-punishment effects of alcohol.
1988,
Pubmed
Mahmoudi,
Chronic intermittent ethanol treatment in rats increases GABA(A) receptor alpha4-subunit expression: possible relevance to alcohol dependence.
1997,
Pubmed
McLeod,
Family history of alcoholism in women with generalized anxiety disorder who have premenstrual syndrome: patient reports of premenstrual alcohol consumption and symptoms of anxiety.
1994,
Pubmed
Mihalek,
GABA(A)-receptor delta subunit knockout mice have multiple defects in behavioral responses to ethanol.
2001,
Pubmed
Mihic,
Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.
1997,
Pubmed
,
Xenbase
Nusser,
Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells.
1998,
Pubmed
Smith,
GABA(A) receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroid.
1998,
Pubmed
Sundström,
Patients with premenstrual syndrome have a different sensitivity to a neuroactive steroid during the menstrual cycle compared to control subjects.
1998,
Pubmed
Ueno,
Alcohol actions on GABA(A) receptors: from protein structure to mouse behavior.
2001,
Pubmed
Wan,
Low ethanol concentrations enhance GABAergic inhibitory postsynaptic potentials in hippocampal pyramidal neurons only after block of GABAB receptors.
1996,
Pubmed
