Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Intracellular magnesium blocks sodium outward currents in a voltage- and dose-dependent manner.
Pusch M
,
Conti F
,
Stühmer W
.
???displayArticle.abstract??? Tail currents through Na+ channels have been measured in inside-out patches from Xenopus laevis oocytes injected with cDNA-derived mRNA coding for the rat brain type II Na+ channel. It is shown that intracellular Mg2+ blocks outward currents in a voltage- and dose-dependent manner with a half blocking concentration between 3 and 4 mM at 0 mV and a voltage dependence of e-fold per 49 mV.
Almers,
Voltage clamp of rat and human skeletal muscle: measurements with an improved loose-patch technique.
1984, Pubmed
Almers,
Voltage clamp of rat and human skeletal muscle: measurements with an improved loose-patch technique.
1984,
Pubmed
Alvarez-Leefmans,
Intracellular free magnesium in frog skeletal muscle fibres measured with ion-selective micro-electrodes.
1986,
Pubmed
Begenisich,
Sodium channel permeation in squid axons. I: Reversal potential experiments.
1980,
Pubmed
Begenisich,
Sodium channel permeation in squid axons. II: Non-independence and current-voltage relations.
1980,
Pubmed
Bezanilla,
Inactivation of the sodium channel. I. Sodium current experiments.
1977,
Pubmed
Hamill,
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.
1981,
Pubmed
Horie,
Voltage-dependent magnesium block of adenosine-triphosphate-sensitive potassium channel in guinea-pig ventricular cells.
1987,
Pubmed
Horie,
Rectification of muscarinic K+ current by magnesium ion in guinea pig atrial cells.
1987,
Pubmed
Matsuda,
Open-state substructure of inwardly rectifying potassium channels revealed by magnesium block in guinea-pig heart cells.
1988,
Pubmed
Mayer,
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones.
,
Pubmed
Methfessel,
Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels.
1986,
Pubmed
,
Xenbase
Nilius,
Calcium block of guinea-pig heart sodium channels with and without modification by the piperazinylindole DPI 201-106.
1988,
Pubmed
Noda,
Existence of distinct sodium channel messenger RNAs in rat brain.
,
Pubmed
Pappone,
Voltage-clamp experiments in normal and denervated mammalian skeletal muscle fibres.
1980,
Pubmed
Stühmer,
Patch clamp characterization of sodium channels expressed from rat brain cDNA.
1987,
Pubmed
,
Xenbase
White,
Effects of intracellular free magnesium on calcium current in isolated cardiac myocytes.
1988,
Pubmed
