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Drosophila goosecoid participates in neural development but not in body axis formation.
Hahn M
,
Jäckle H
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In vertebrate embryos, the homeobox gene goosecoid (gsc) is expressed in the gastrulaorganizer region and in later arising embryonic tissues including the foregut anlage. Ectopic expression and loss-of-function studies have demonstrated that Xenopus gsc elicits a dorsalizing activity that contributes to body axis formation. Here we report that the gsc gene is conserved in invertebrates. In Drosophila, D-gsc is expressed most strongly in the foregut anlage, which gives rise to the foregut proper and the stomatogastric nervous system (SNS). D-gsc expression overlaps with one of the three SNS precursor groups invaginating from the foregut anlage. Embryos mutant for D-gsc gastrulate normally but show disrupted invagination in the SNS primordium and lack one specific SNS ganglion. In addition, D-gsc mutant embryos show a less well defined defect in foregut arrangement. Our results indicate that this invertebrate homolog of gsc is not required for gastrulation but plays a role in neurogenesis in post-gastrula Drosophila embryos.
Berleth,
The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo.
1988, Pubmed
Berleth,
The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo.
1988,
Pubmed
Blum,
Gastrulation in the mouse: the role of the homeobox gene goosecoid.
1992,
Pubmed
,
Xenbase
Blum,
Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32.1.
1994,
Pubmed
,
Xenbase
Blumberg,
Organizer-specific homeobox genes in Xenopus laevis embryos.
1991,
Pubmed
,
Xenbase
Cheyette,
The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system.
1994,
Pubmed
Cho,
Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid.
1991,
Pubmed
,
Xenbase
Cohen,
apterous, a gene required for imaginal disc development in Drosophila encodes a member of the LIM family of developmental regulatory proteins.
1992,
Pubmed
Cooley,
Insertional mutagenesis of the Drosophila genome with single P elements.
1988,
Pubmed
Finkelstein,
The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures.
1990,
Pubmed
Gaunt,
Expression of the mouse goosecoid gene during mid-embryogenesis may mark mesenchymal cell lineages in the developing head, limbs and body wall.
1993,
Pubmed
González-Gaitán,
Redundant functions of the genes knirps and knirps-related for the establishment of anterior Drosophila head structures.
1994,
Pubmed
González-Gaitán,
Invagination centers within the Drosophila stomatogastric nervous system anlage are positioned by Notch-mediated signaling which is spatially controlled through wingless.
1995,
Pubmed
Hartenstein,
Embryonic development of the stomatogastric nervous system in Drosophila.
1994,
Pubmed
Izpisúa-Belmonte,
The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm.
1993,
Pubmed
,
Xenbase
Karpen,
Analysis of subtelomeric heterochromatin in the Drosophila minichromosome Dp1187 by single P element insertional mutagenesis.
1992,
Pubmed
Poulson,
Chromosomal Deficiencies and the Embryonic Development of Drosophila Melanogaster.
1937,
Pubmed
Rivera-Pérez,
Goosecoid is not an essential component of the mouse gastrula organizer but is required for craniofacial and rib development.
1995,
Pubmed
,
Xenbase
Simeone,
A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo.
1993,
Pubmed
Stachel,
Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish.
1993,
Pubmed
Steinbeisser,
Xenopus goosecoid: a gene expressed in the prechordal plate that has dorsalizing activity.
1993,
Pubmed
,
Xenbase
Steinbeisser,
The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: a loss-of-function study using antisense RNA.
1995,
Pubmed
,
Xenbase
Steinbeisser,
Xenopus axis formation: induction of goosecoid by injected Xwnt-8 and activin mRNAs.
1993,
Pubmed
,
Xenbase
Tepass,
crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia.
1990,
Pubmed
Thisse,
Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas.
1994,
Pubmed
Treisman,
The homeodomain: a new face for the helix-turn-helix?
1992,
Pubmed
Treisman,
A single amino acid can determine the DNA binding specificity of homeodomain proteins.
1989,
Pubmed
Weigel,
The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo.
1989,
Pubmed
Yamada,
Targeted mutation of the murine goosecoid gene results in craniofacial defects and neonatal death.
1995,
Pubmed
Zipursky,
Neuronal development in the Drosophila retina: monoclonal antibodies as molecular probes.
1984,
Pubmed
