Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-37959
Cell 2008 May 30;1335:767-9. doi: 10.1016/j.cell.2008.05.013.
Show Gene links Show Anatomy links

p53 regulation orchestrates the TGF-beta response.



???displayArticle.abstract???
Among its multiple functions, p53 is a critical regulator of TGF-beta responses. Sasai et al. (2008) now identify a new p53 inhibitory protein, XFDL156. During embryonic development, this factor is expressed in the ectoderm germ layer and maintains the pluripotency of ectodermal cells by inhibiting TGF-beta target genes that promote mesoderm specification.

???displayArticle.pubmedLink??? 18510920
???displayArticle.link??? Cell


Species referenced: Xenopus
Genes referenced: fgf2 smad1 smad2 tbx2 tgfb1 tp53 trim33 znf585b

References :
Sasai, Ectodermal factor restricts mesoderm differentiation by inhibiting p53. 2008, Pubmed, Xenbase