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Mol Cell Biol
1998 Jan 01;181:269-75. doi: 10.1128/MCB.18.1.269.
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Telomere variation in Xenopus laevis.
Bassham S
,
Beam A
,
Shampay J
.
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Eukaryotic telomeres are variable at several levels, from the length of the simple sequence telomeric repeat tract in different cell types to the presence or number of telomere-adjacent DNA sequence elements in different strains or individuals. We have investigated the sequence organization of Xenopus laevis telomeres by use of the vertebrate telomeric repeat (TTAGGG)n and blot hybridization analysis. The (TTAGGG)n-hybridizing fragments, which ranged from less than 10 to over 50 kb with frequently cutting enzymes, defined a pattern that was polymorphic between individuals. BAL 31 exonuclease treatment confirmed that these fragments were telomeric. The polymorphic fragments analyzed did not hybridize to 5S RNA sequences, which are telomeric according to in situ hybridization. When telomeric fragments from offspring (whole embryos) were compared to those from the spleens of the parents, the inheritance pattern of some bands was found to be unusual. Furthermore, in one cross, the telomeres of the embryo were shorter than the telomeres of the parents' spleen, and in another, the male's testis telomeres were shorter than those of the male's spleen. Our data are consistent with a model for chromosome behavior that involves a significant amount of DNA rearrangement at telomeres and suggest that length regulation of Xenopus telomeres is different from that observed for Mus spretus and human telomeres.
Blackburn,
Telomeres: no end in sight.
1994, Pubmed
Blackburn,
Telomeres: no end in sight.
1994,
Pubmed
Broccoli,
Telomerase activity in normal and malignant hematopoietic cells.
1995,
Pubmed
Broun,
Telomeric arrays display high levels of heritable polymorphism among closely related plant varieties.
1992,
Pubmed
Brown,
Structure and polymorphism of human telomere-associated DNA.
1990,
Pubmed
Callan,
The lampbrush chromosomes of Xenopus laevis: preparation, identification, and distribution of 5S DNA sequences.
1987,
Pubmed
,
Xenbase
Cardenas,
A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins.
1993,
Pubmed
,
Xenbase
Carlson,
Evolution of the dispersed SUC gene family of Saccharomyces by rearrangements of chromosome telomeres.
1985,
Pubmed
Charron,
Molecular evolution of the telomere-associated MAL loci of Saccharomyces.
1989,
Pubmed
Cooke,
Hypervariable telomeric sequences from the human sex chromosomes are pseudoautosomal.
,
Pubmed
Cooper,
Regulation of telomere length and function by a Myb-domain protein in fission yeast.
1997,
Pubmed
Corcoran,
Homologous recombination within subtelomeric repeat sequences generates chromosome size polymorphisms in P. falciparum.
1988,
Pubmed
Cross,
The structure of a subterminal repeated sequence present on many human chromosomes.
1990,
Pubmed
Cross,
Cloning of human telomeres by complementation in yeast.
1989,
Pubmed
de Bruin,
The polymorphic subtelomeric regions of Plasmodium falciparum chromosomes contain arrays of repetitive sequence elements.
1994,
Pubmed
de Lange,
Structure and variability of human chromosome ends.
1990,
Pubmed
Fedoroff,
The nucleotide sequence of oocyte 5S DNA in Xenopus laevis. I. The AT-rich spacer.
1978,
Pubmed
,
Xenbase
Hardy,
A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation.
1992,
Pubmed
Harley,
Telomeres and telomerase in aging and cancer.
1995,
Pubmed
Harper,
Chromosomal mapping of Xenopus 5S genes: somatic-type versus oocyte-type.
1983,
Pubmed
,
Xenbase
Horowitz,
Rearrangements of highly polymorphic regions near telomeres of Saccharomyces cerevisiae.
1984,
Pubmed
Kipling,
Hypervariable ultra-long telomeres in mice.
1990,
Pubmed
Louis,
The chromosome end in yeast: its mosaic nature and influence on recombinational dynamics.
1994,
Pubmed
Louis,
Mitotic recombination among subtelomeric Y' repeats in Saccharomyces cerevisiae.
1990,
Pubmed
Lustig,
Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length.
1990,
Pubmed
Lustig,
Identification of yeast mutants with altered telomere structure.
1986,
Pubmed
Mantell,
Telomerase activity in germline and embryonic cells of Xenopus.
1994,
Pubmed
,
Xenbase
Meyne,
Conservation of the human telomere sequence (TTAGGG)n among vertebrates.
1989,
Pubmed
Narayanswami,
High resolution mapping of Xenopus laevis 5S and ribosomal RNA genes by EM in situ hybridization.
1990,
Pubmed
,
Xenbase
Ness,
RTM1: a member of a new family of telomeric repeated genes in yeast.
1995,
Pubmed
P,
Preparation, restriction, and hybridization analysis of Mammalian genomic DNA for pulsed-field gel electrophoresis.
1992,
Pubmed
Pace,
Long insertions within telomeres contribute to chromosome size polymorphism in Plasmodium berghei.
1990,
Pubmed
Pardue,
Location of the genes for 5S ribosomal RNA in Xenopus laevis.
1973,
Pubmed
,
Xenbase
Prowse,
Developmental and tissue-specific regulation of mouse telomerase and telomere length.
1995,
Pubmed
Röder,
Genetic and physical mapping of barley telomeres.
1993,
Pubmed
Runge,
TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae.
1996,
Pubmed
Shampay,
Generation of telomere-length heterogeneity in Saccharomyces cerevisiae.
1988,
Pubmed
Slagboom,
Genetic determination of telomere size in humans: a twin study of three age groups.
1994,
Pubmed
Starling,
Extensive telomere repeat arrays in mouse are hypervariable.
1990,
Pubmed
van Steensel,
Control of telomere length by the human telomeric protein TRF1.
1997,
Pubmed
Walmsley,
Genetic control of chromosome length in yeast.
1985,
Pubmed
Wilkie,
Stable length polymorphism of up to 260 kb at the tip of the short arm of human chromosome 16.
1991,
Pubmed
Zakian,
Structure and function of telomeres.
1989,
Pubmed
Zakian,
Telomeres: beginning to understand the end.
1995,
Pubmed
Zakian,
Distribution of telomere-associated sequences on natural chromosomes in Saccharomyces cerevisiae.
1988,
Pubmed
