Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract??? Tissue regeneration entails replenishing of damaged cells, appropriate cell differentiation and inclusion of regenerated cells into functioning tissues. In adult humans, the capacity of the injured spinal cord and muscle to self-repair is limited. In contrast, the amphibian larva can regenerate its tail after amputation with complete recovery of muscle, notochord and spinal cord. The cellular and molecular mechanisms underlying this phenomenon are still unclear. Here we show that upon injury muscle cell precursors exhibit Ca(2+) transients that depend on Ca(2+) release from ryanodine receptor-operated stores. Blockade of these transients impairs muscle regeneration. Furthermore, inhibiting Ca(2+) transients in the regenerating tail prevents the activation and proliferation of muscle satellite cells, which results in deficient muscle replenishment. These findings suggest that Ca(2+)-mediated activity is critical for the early stages of muscle regeneration, which may lead to developing effective therapies for tissue repair.
Adams,
H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration.
2007, Pubmed,
Xenbase
Adams,
H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration.
2007,
Pubmed
,
Xenbase
Beck,
Beyond early development: Xenopus as an emerging model for the study of regenerative mechanisms.
2009,
Pubmed
,
Xenbase
Belgacem,
Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord.
2011,
Pubmed
,
Xenbase
Bolteus,
GABA release and uptake regulate neuronal precursor migration in the postnatal subventricular zone.
2004,
Pubmed
Boncompagni,
Structural differentiation of skeletal muscle fibers in the absence of innervation in humans.
2007,
Pubmed
Borodinsky,
Extracellular potassium concentration regulates proliferation of immature cerebellar granule cells.
1998,
Pubmed
Borodinsky,
Activity-dependent homeostatic specification of transmitter expression in embryonic neurons.
2004,
Pubmed
,
Xenbase
Borodinsky,
Activity-dependent neurotransmitter-receptor matching at the neuromuscular junction.
2007,
Pubmed
,
Xenbase
Bortone,
KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner.
2009,
Pubmed
Campbell,
Spatiotemporal characterization of short versus long duration calcium transients in embryonic muscle and their role in myofibrillogenesis.
2006,
Pubmed
,
Xenbase
Campion,
Changes in the satellite cell population during postnatal growth of pig skeletal muscle.
1981,
Pubmed
Chen,
Control of muscle regeneration in the Xenopus tadpole tail by Pax7.
2006,
Pubmed
,
Xenbase
Cooper,
In vivo satellite cell activation via Myf5 and MyoD in regenerating mouse skeletal muscle.
1999,
Pubmed
Demarque,
Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior.
2010,
Pubmed
,
Xenbase
Deuchar,
Regeneration of the tail bud in Xenopus embryos.
1975,
Pubmed
,
Xenbase
Dulcis,
Illumination controls differentiation of dopamine neurons regulating behaviour.
2008,
Pubmed
,
Xenbase
Ferrari,
Calcium signaling in the developing Xenopus myotome.
1999,
Pubmed
,
Xenbase
Ferrari,
Spontaneous calcium transients regulate myofibrillogenesis in embryonic Xenopus myocytes.
1996,
Pubmed
,
Xenbase
Ferrari,
A calcium signaling cascade essential for myosin thick filament assembly in Xenopus myocytes.
1998,
Pubmed
,
Xenbase
Fiszman,
GABA induces proliferation of immature cerebellar granule cells grown in vitro.
1999,
Pubmed
Gamble,
Electron microscope observations on human fetal striated muscle.
1978,
Pubmed
Gardner,
Defining Akt actions in muscle differentiation.
2012,
Pubmed
Gargioli,
Cell lineage tracing during Xenopus tail regeneration.
2004,
Pubmed
,
Xenbase
Gu,
Low-threshold Ca2+ current and its role in spontaneous elevations of intracellular Ca2+ in developing Xenopus neurons.
1993,
Pubmed
,
Xenbase
Guardiola,
Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin.
2012,
Pubmed
Hartley,
Skeletal muscle satellite cells appear during late chicken embryogenesis.
1992,
Pubmed
HAUSER,
Regeneration in isolated tails of Xenopus larvae.
1962,
Pubmed
,
Xenbase
Ho,
TGF-beta signaling is required for multiple processes during Xenopus tail regeneration.
2008,
Pubmed
,
Xenbase
Holliday,
Spontaneous calcium influx and its roles in differentiation of spinal neurons in culture.
1990,
Pubmed
,
Xenbase
Kahn,
Satellite cells in mature, uninjured skeletal muscle of the lizard tail.
1974,
Pubmed
Kannan,
Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells.
1997,
Pubmed
Love,
Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration.
2013,
Pubmed
,
Xenbase
Marek,
cJun integrates calcium activity and tlx3 expression to regulate neurotransmitter specification.
2010,
Pubmed
,
Xenbase
MAURO,
Satellite cell of skeletal muscle fibers.
1961,
Pubmed
Mochii,
Tail regeneration in the Xenopus tadpole.
2007,
Pubmed
,
Xenbase
Mourikis,
A critical requirement for notch signaling in maintenance of the quiescent skeletal muscle stem cell state.
2012,
Pubmed
Rosen,
Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras.
1994,
Pubmed
Schultz,
Satellite cell proliferative compartments in growing skeletal muscles.
1996,
Pubmed
Shen,
The EGF-CFC gene family in vertebrate development.
2000,
Pubmed
Soto,
Inositol kinase and its product accelerate wound healing by modulating calcium levels, Rho GTPases, and F-actin assembly.
2013,
Pubmed
,
Xenbase
Swapna,
Interplay between electrical activity and bone morphogenetic protein signaling regulates spinal neuron differentiation.
2012,
Pubmed
,
Xenbase
Taniguchi,
Spinal cord is required for proper regeneration of the tail in Xenopus tadpoles.
2008,
Pubmed
,
Xenbase
Tran,
Insights into skeletal muscle development and applications in regenerative medicine.
2013,
Pubmed
Tseng,
Apoptosis is required during early stages of tail regeneration in Xenopus laevis.
2007,
Pubmed
,
Xenbase
Tseng,
Induction of vertebrate regeneration by a transient sodium current.
2010,
Pubmed
,
Xenbase
Vandenberghe,
ORAI1 calcium channel orchestrates skin homeostasis.
2013,
Pubmed
Wagers,
Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis.
2005,
Pubmed
Weissman,
Calcium waves propagate through radial glial cells and modulate proliferation in the developing neocortex.
2004,
Pubmed
Xiao,
TRAF6 promotes myogenic differentiation via the TAK1/p38 mitogen-activated protein kinase and Akt pathways.
2012,
Pubmed
