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Human recombinant activin A, which is identical with erythroid differentiation factor (EDF), was tested for its mesoderm-inducing activity in concentrations from 0.3-50 ng/ml, using ectoderm of Xenopus late blastula (Stage 9) as the responding tissue. At a low concentration of activin A, blood-like cells, mesenchyme, and coelomic epithelium were induced; at a moderate concentration muscle and neural tissue, and at a high concentration notochord. Activin A thus induced all mesodermal tissues in a dose-dependent manner, such that a low dose induced ventral structures and a high dose induced dorsal structures. Activin may act as an intrinsic inducing molecule responsible for establishing the dorso-ventral axis in early Xenopus development.
Asashima,
The vegetalizing factor belongs to a family of mesoderm-inducing proteins related to erythroid differentiation factor.
1990, Pubmed,
Xenbase
Asashima,
The vegetalizing factor belongs to a family of mesoderm-inducing proteins related to erythroid differentiation factor.
1990,
Pubmed
,
Xenbase
Asashima,
Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor).
1990,
Pubmed
,
Xenbase
Boterenbrood,
The formation of the mesoderm in urodelean amphibians : V. Its regional induction by the endoderm.
1973,
Pubmed
Cooke,
Mesoderm-inducing factors and Spemann's organiser phenomenon in amphibian development.
1989,
Pubmed
,
Xenbase
Dale,
Regional specification within the mesoderm of early embryos of Xenopus laevis.
1987,
Pubmed
,
Xenbase
Eto,
Purification and characterization of erythroid differentiation factor (EDF) isolated from human leukemia cell line THP-1.
1987,
Pubmed
Geithe,
A vegetalizing inducing factor. Isolation and chemical properties.
1981,
Pubmed
Green,
The biological effects of XTC-MIF: quantitative comparison with Xenopus bFGF.
1990,
Pubmed
,
Xenbase
Green,
Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate.
1990,
Pubmed
,
Xenbase
Grunz,
Induction of mesodermal tissues by acidic and basic heparin binding growth factors.
1988,
Pubmed
,
Xenbase
Kimelman,
The presence of fibroblast growth factor in the frog egg: its role as a natural mesoderm inducer.
1988,
Pubmed
,
Xenbase
Knöchel,
Mesoderm-inducing factors. Their possible relationship to heparin-binding growth factors and transforming growth factor-beta.
1987,
Pubmed
Knöchel,
Mesoderm induction by transforming growth factor beta: medium conditioned by TGF-beta-treated ectoderm enhances the inducing activity.
1989,
Pubmed
,
Xenbase
Mason,
Activin B: precursor sequences, genomic structure and in vitro activities.
1989,
Pubmed
Murata,
Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain.
1988,
Pubmed
Nieuwkoop,
The formation of the mesoderm in urodelean amphibians : IV. Qualitative evidence for the purely "ectodermal" origin of the entire mesoderm and of the pharyngeal endoderm.
1972,
Pubmed
Rosa,
Mesoderm induction in amphibians: the role of TGF-beta 2-like factors.
1988,
Pubmed
,
Xenbase
Slack,
Mesoderm induction in early Xenopus embryos by heparin-binding growth factors.
,
Pubmed
,
Xenbase
Smith,
Mesoderm induction and mesoderm-inducing factors in early amphibian development.
1989,
Pubmed
Smith,
Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A.
1990,
Pubmed
,
Xenbase
Thomsen,
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures.
1990,
Pubmed
,
Xenbase
van den Eijnden-Van Raaij,
Activin-like factor from a Xenopus laevis cell line responsible for mesoderm induction.
1990,
Pubmed
,
Xenbase
