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Proc Natl Acad Sci U S A
2001 Jun 19;9813:7414-9. doi: 10.1073/pnas.131090498.
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A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans.
Xu EY
,
Moore FL
,
Pera RA
.
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The Deleted in AZoospermia (DAZ) genes encode potential RNA-binding proteins that are expressed exclusively in prenatal and postnatal germ cells and are strong candidates for human fertility factors. Here we report the identification of an additional member of the DAZ gene family, which we have called BOULE. With the identification of this gene, it is clear that the human DAZ gene family contains at least three members: DAZ, a Y-chromosome gene cluster that arose 30-40 million years ago and whose deletion is linked to infertility in men; DAZL, the "father" of DAZ, a gene that maps to human chromosome 3 and has homologs required for both female and male germ cell development in other organisms; and BOULE, a gene that we propose is the "grandfather" of DAZ and maps to human chromosome 2. Human and mouse BOULE resemble the invertebrate meiotic regulator Boule, the proposed ortholog of DAZ, in sequence and expression pattern and hence likely perform a similar meiotic function. In contrast, the previously identified human DAZ and DAZL are expressed much earlier than BOULE in prenatal germ stem cells and spermatogonia; DAZL also is expressed in female germ cells. These data suggest that homologs of the DAZ gene family can be grouped into two subfamilies (BOULE and DAZL) and that members of the DAZ family evolved from an ancestral meiotic regulator, Boule, to assume distinct, yet overlapping, functions in germ cell development.
Agulnik,
Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations.
1998, Pubmed
Agulnik,
Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations.
1998,
Pubmed
Bielawski,
Positive and negative selection in the DAZ gene family.
2001,
Pubmed
Burd,
Conserved structures and diversity of functions of RNA-binding proteins.
1994,
Pubmed
Carani,
cynDAZLA: a cynomolgus monkey homologue of the human autosomal DAZ gene.
1997,
Pubmed
Chai,
A putative human male infertility gene DAZLA: genomic structure and methylation status.
1997,
Pubmed
Cheng,
Biphasic subcellular localization of the DAZL-related protein boule in Drosophila spermatogenesis.
1998,
Pubmed
Cooke,
RNA-binding proteins and human male infertility.
1997,
Pubmed
Cooke,
A murine homologue of the human DAZ gene is autosomal and expressed only in male and female gonads.
1996,
Pubmed
Dorfman,
Human DAZL1 encodes a candidate fertility factor in women that localizes to the prenatal and postnatal germ cells.
1999,
Pubmed
Eberhart,
Meiotic cell cycle requirement for a fly homologue of human Deleted in Azoospermia.
1996,
Pubmed
Gromoll,
The Old World monkey DAZ (Deleted in AZoospermia) gene yields insights into the evolution of the DAZ gene cluster on the human Y chromosome.
1999,
Pubmed
Haag,
Rolling back to BOULE.
2001,
Pubmed
Houston,
A critical role for Xdazl, a germ plasm-localized RNA, in the differentiation of primordial germ cells in Xenopus.
2000,
Pubmed
,
Xenbase
Houston,
A Xenopus DAZ-like gene encodes an RNA component of germ plasm and is a functional homologue of Drosophila boule.
1998,
Pubmed
,
Xenbase
Karashima,
Caenorhabditis elegans homologue of the human azoospermia factor DAZ is required for oogenesis but not for spermatogenesis.
2000,
Pubmed
Maegawa,
Maternal mRNA localization of zebrafish DAZ-like gene.
1999,
Pubmed
,
Xenbase
Maines,
Post-transcriptional regulation of the meiotic Cdc25 protein Twine by the Dazl orthologue Boule.
1999,
Pubmed
Maiwald,
Isolation of a mouse homolog of the human DAZ (Deleted in Azoospermia) gene.
1996,
Pubmed
Menke,
Expression of DAZ, an azoospermia factor candidate, in human spermatogonia.
1997,
Pubmed
Mita,
Expression of Xenopus Daz-like protein during gametogenesis and embryogenesis.
2000,
Pubmed
,
Xenbase
Reijo,
Mouse autosomal homolog of DAZ, a candidate male sterility gene in humans, is expressed in male germ cells before and after puberty.
1996,
Pubmed
Reijo,
Severe oligozoospermia resulting from deletions of azoospermia factor gene on Y chromosome.
1996,
Pubmed
Reijo,
Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene.
1995,
Pubmed
Reijo,
DAZ family proteins exist throughout male germ cell development and transit from nucleus to cytoplasm at meiosis in humans and mice.
2000,
Pubmed
Ruggiu,
The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis.
1997,
Pubmed
Saxena,
The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.
1996,
Pubmed
Saxena,
Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome.
2000,
Pubmed
Seboun,
Gene sequence, localization, and evolutionary conservation of DAZLA, a candidate male sterility gene.
1997,
Pubmed
Shan,
A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad.
1996,
Pubmed
Tsui,
Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.
2000,
Pubmed
Yen,
The human autosomal gene DAZLA: testis specificity and a candidate for male infertility.
1996,
Pubmed
