XB-ART-19716
Biochim Biophys Acta
1995 May 17;12621:95-8.
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XB/U-cadherin mRNA contains cytoplasmic polyadenylation elements and is polyadenylated during oocyte maturation in Xenopus laevis.
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Cytoplasmic polyadenylation elements (CPE) are distinct sequence motifs in the 3'-untranslated region of mRNAs. They control translation of these RNAs by cytoplasmic polyadenylation. We show that the mRNA of the cell adhesion molecule XB/U-cadherin contains two CPE motifs. With oocyte maturation this mRNA becomes polyadenylated and increasingly recruited into the polysomal fraction. Our results give evidence that CPEs of the XB/U-cadherin mRNA are responsible for the XB/U-cadherin protein increase during oocyte maturation.
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Species referenced: Xenopus laevis
Genes referenced: cdh3