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XB-ART-42433
EMBO Rep 2011 Jan 01;121:43-9. doi: 10.1038/embor.2010.185.
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Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling.

Puppo F , Thomé V , Lhoumeau AC , Cibois M , Gangar A , Lembo F , Belotti E , Marchetto S , Lécine P , Prébet T , Sebbagh M , Shin WS , Lee ST , Kodjabachian L , Borg JP .


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The receptor protein tyrosine kinase 7 (PTK7) was recently shown to participate in noncanonical Wnt/planar cell polarity signalling during mouse and frog embryonic development. In this study, we report that PTK7 interacts with β-catenin in a yeast two-hybrid assay and mammalian cells. PTK7-deficient cells exhibit weakened β-catenin/T-cell factor transcriptional activity on Wnt3a stimulation. Furthermore, Xenopus PTK7 is required for the formation of Spemann's organizer and for Siamois promoter activation, events that require β-catenin transcriptional activity. Using epistatic assays, we demonstrate that PTK7 functions upstream from glycogen synthase kinase 3. Taken together, our data reveal a new and conserved role for PTK7 in the Wnt canonical signalling pathway.

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Species referenced: Xenopus laevis
Genes referenced: ctnnb1 ptk7 sia1 wnt3a
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References [+] :
Angers, Proximal events in Wnt signal transduction. 2009, Pubmed