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XB-ART-37086
Differentiation 2007 Jul 01;756:507-18. doi: 10.1111/j.1432-0436.2007.00159.x.
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Ribonucleoprotein remodeling during RNA localization.

Lewis RA , Mowry KL .


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Cytoplasmic RNA localization is a means to create polarity by restricting protein expression to a discrete subcellular location. RNA localization is a multistep process that begins with the recognition of cis-acting sequences within the RNA by specific trans-factors, and RNAs are localized in ribonucleoprotein (RNP) complexes that contain both the RNA and numerous protein components. Components of the localization machinery transport the RNP complex, usually in a translationally repressed state, to a distinct subcellular region, resulting in spatially restricted gene expression. Recent efforts to identify both the cis- and trans-factors required for RNA localization have elucidated RNA-protein interactions that are remodeled during localization.

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