Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia.
Taulman PD
,
Haycraft CJ
,
Balkovetz DF
,
Yoder BK
.
???displayArticle.abstract???
Mutations in Tg737 cause a wide spectrum of phenotypes, including random left-right axis specification, polycystic kidney disease, liver and pancreatic defects, hydrocephalus, and skeletal patterning abnormalities. To further assess the biological function of Tg737 and its role in the mutant pathology, we identified the cell population expressing Tg737 and determined the subcellular localization of its protein product called Polaris. Tg737 expression is associated with cells possessing either motile or immotile cilia and sperm. Similarly, Polaris concentrated just below the apical membrane in the region of the basal bodies and within the cilia or flagellar axoneme. The data suggest that Polaris functions in a ciliogenic pathway or in cilia maintenance, a role supported by the loss of cilia on the ependymal cell layer in ventricles of Tg737(orpk) brains and by the lack of node cilia in Tg737(Delta2-3betaGal) mutants.
Afzelius,
A human syndrome caused by immotile cilia.
1976, Pubmed
Afzelius,
A human syndrome caused by immotile cilia.
1976,
Pubmed
Balci,
New syndrome?: Three sibs diagnosed prenatally with situs inversus totalis, renal and pancreatic dysplasia, and cysts.
2000,
Pubmed
Balkovetz,
Hepatocyte growth factor alters the polarity of Madin-Darby canine kidney cell monolayers.
1997,
Pubmed
Bannister,
Ventricular ependyma of normal and hydrocephalic subjects: a scanning electronmicroscopic study.
1980,
Pubmed
Blatch,
The tetratricopeptide repeat: a structural motif mediating protein-protein interactions.
1999,
Pubmed
Blatt,
Forkhead transcription factor HFH-4 expression is temporally related to ciliogenesis.
1999,
Pubmed
Brody,
Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice.
2000,
Pubmed
Bulger,
Scanning and transmission electron microscopy of the rat kidney.
1974,
Pubmed
Chen,
Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry.
1998,
Pubmed
Cole,
Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons.
1998,
Pubmed
Del Cerro,
The Purkinje cell cilium.
1969,
Pubmed
Händel,
Selective targeting of somatostatin receptor 3 to neuronal cilia.
1999,
Pubmed
Kozminski,
A motility in the eukaryotic flagellum unrelated to flagellar beating.
1993,
Pubmed
Kozminski,
The Chlamydomonas kinesin-like protein FLA10 is involved in motility associated with the flagellar membrane.
1995,
Pubmed
LEBLOND,
Definition of the stages of the cycle of the seminiferous epithelium in the rat.
1952,
Pubmed
Marszalek,
Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II.
1999,
Pubmed
Mochizuki,
Cloning of inv, a gene that controls left/right asymmetry and kidney development.
1998,
Pubmed
Moyer,
Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice.
1994,
Pubmed
Murcia,
The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination.
2000,
Pubmed
,
Xenbase
Nakamura,
Role of disturbance of ependymal ciliary movement in development of hydrocephalus in rats.
1993,
Pubmed
Nonaka,
Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.
1998,
Pubmed
Okada,
Abnormal nodal flow precedes situs inversus in iv and inv mice.
1999,
Pubmed
Renthal,
Beta IV is the major beta-tubulin isotype in bovine cilia.
1993,
Pubmed
Richards,
Isolation and characterization of liver epithelial cell lines from wild-type and mutant TgN737Rpw mice.
1997,
Pubmed
Satir,
The physiology of cilia and mucociliary interactions.
1990,
Pubmed
Shimizu,
Ultrastructure and movement of the ependymal and tracheal cilia in congenitally hydrocephalic WIC-Hyd rats.
1992,
Pubmed
Supp,
Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries.
1999,
Pubmed
Supp,
Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice.
1997,
Pubmed
Takeda,
Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis.
1999,
Pubmed
Wagner,
Left-right development: the roles of nodal cilia.
2000,
Pubmed
Webber,
Fine structure of mammalian renal cilia.
1975,
Pubmed
Wheatley,
Expression of primary cilia in mammalian cells.
1996,
Pubmed
Yoder,
Functional correction of renal defects in a mouse model for ARPKD through expression of the cloned wild-type Tg737 cDNA.
1996,
Pubmed
Yoder,
Insertional mutagenesis and molecular analysis of a new gene associated with polycystic kidney disease.
1995,
Pubmed
Yoder,
Differential rescue of the renal and hepatic disease in an autosomal recessive polycystic kidney disease mouse mutant. A new model to study the liver lesion.
1997,
Pubmed
Yokoyama,
Reversal of left-right asymmetry: a situs inversus mutation.
1993,
Pubmed
