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XB-ART-6431
Nat Neurosci 2002 Nov 01;511:1169-76. doi: 10.1038/nn952.
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A transient receptor potential channel expressed in taste receptor cells.

Pérez CA , Huang L , Rong M , Kozak JA , Preuss AK , Zhang H , Max M , Margolskee RF .


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We used differential screening of cDNAs from individual taste receptor cells to identify candidate taste transduction elements in mice. Among the differentially expressed clones, one encoded Trpm5, a member of the mammalian family of transient receptor potential (TRP) channels. We found Trpm5 to be expressed in a restricted manner, with particularly high levels in taste tissue. In taste cells, Trpm5 was coexpressed with taste-signaling molecules such as alpha-gustducin, Ggamma13, phospholipase C-beta2 (PLC-beta2) and inositol 1,4,5-trisphosphate receptor type III (IP3R3). Our heterologous expression studies of Trpm5 indicate that it functions as a cationic channel that is gated when internal calcium stores are depleted. Trpm5 may be responsible for capacitative calcium entry in taste receptor cells that respond to bitter and/or sweet compounds.

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Species referenced: Xenopus laevis
Genes referenced: trpm4 trpm5