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A cDNA encoding the precursor of a bombesinlike peptide was isolated from brain of Xenopus laevis. The predicted end product resembles neuromedin B, which was originally isolated from mammalian spinal cord. The mRNA for this precursor was also present in gastrointestinal tract and in ovaries. Moreover, it could be detected in early embryos (stage 2 and stage 10) of X. laevis. These findings suggest novel roles for peptides of the bombesin family in oocyte maturation and early amphibian development.
FIG. 1. Nucleotide and deduced amino acid sequence of clone
B5A from brain ofX. laevis. The amino acid sequence is given in the
single-letter code; only the sequence of the bombesinlike peptide is
emphasized by using the three-letter code. The stop codon is marked
(/), and the polyadenylylation signal is underlined. The sense and
antisense oligonucleotides used for the PCR experiments are overlined.
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