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Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.
Ito I
,
Tanabe S
,
Kohda A
,
Sugiyama H
.
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1. Allosteric potentiation of the ionotropic quisqualate (iQA) receptor by a nootropic drug aniracetam (1-p-anisoyl-2-pyrrolidinone) was investigated using Xenopus oocytes injected with rat brain mRNA and rat hippocampal slices. 2. Aniracetam potentiates the iQA responses induced in Xenopus oocytes by rat brain mRNA in a reversible manner. This effect was observed above the concentrations of 0.1 mM. Kainate. N-methyl-D-aspartate and gamma-aminobutyric acid responses induced in the same oocytes were not affected. 3. The specific potentiation of iQA responses was accompanied by an increase in the conductance change of iQA and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) responses, but the affinity of receptors for agonist and the ion-selectivity of the channels (reversal potentials) were not changed. 4. Aniracetam reversibly potentiated the iQA responses recorded intracellularly from the pyramidal cells in the CA1 region of rat hippocampal slices. The excitatory postsynaptic potentials (EPSPs) in Schaffer collateral-commissural-CA1 synapses were also potentiated by aniracetam. 5. Population EPSPs recorded in the mossy fibre-CA3 synapses as well as Schaffer-commissural synapses were also potentiated by aniracetam. The amplitudes of the potentiation were not changed by the formation of long-term potentiation.
Ascher,
The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in culture.
1988, Pubmed
Ascher,
The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in culture.
1988,
Pubmed
Bormann,
Electrophysiology of GABAA and GABAB receptor subtypes.
1988,
Pubmed
Cumin,
Effects of the novel compound aniracetam (Ro 13-5057) upon impaired learning and memory in rodents.
1982,
Pubmed
Davies,
Temporally distinct pre- and post-synaptic mechanisms maintain long-term potentiation.
1989,
Pubmed
Gundersen,
Glutamate and kainate receptors induced by rat brain messenger RNA in Xenopus oocytes.
1984,
Pubmed
,
Xenbase
Hirono,
Characterization of glutamate receptors induced in Xenopus oocytes after injection of rat brain mRNA.
1988,
Pubmed
,
Xenbase
Ito,
Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapses.
1988,
Pubmed
Johnson,
Glycine potentiates the NMDA response in cultured mouse brain neurons.
,
Pubmed
Kauer,
A persistent postsynaptic modification mediates long-term potentiation in the hippocampus.
1988,
Pubmed
Kiskin,
Excitatory amino acid receptors in hippocampal neurons: kainate fails to desensitize them.
1986,
Pubmed
MacDermott,
NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones.
,
Pubmed
Mayer,
Concanavalin A selectively reduces desensitization of mammalian neuronal quisqualate receptors.
1989,
Pubmed
Mayer,
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones.
,
Pubmed
Muller,
Contributions of quisqualate and NMDA receptors to the induction and expression of LTP.
1988,
Pubmed
Nowak,
Magnesium gates glutamate-activated channels in mouse central neurones.
,
Pubmed
O'Brien,
Characterization of excitatory amino acid receptors expressed by embryonic chick motoneurons in vitro.
1986,
Pubmed
Okada,
Differential effects of phospholipase inhibitors in long-term potentiation in the rat hippocampal mossy fiber synapses and Schaffer/commissural synapses.
1989,
Pubmed
Rassendren,
A specific quisqualate agonist inhibits kainate responses induced in Xenopus oocytes injected with rat brain RNA.
1989,
Pubmed
,
Xenbase
Snutch,
The use of Xenopus oocytes to probe synaptic communication.
1988,
Pubmed
,
Xenbase
Stelzer,
GABAA responses in hippocampal neurons are potentiated by glutamate.
1989,
Pubmed
Sugiyama,
Glutamate receptor subtypes may be classified into two major categories: a study on Xenopus oocytes injected with rat brain mRNA.
1989,
Pubmed
,
Xenbase
Sugiyama,
A new type of glutamate receptor linked to inositol phospholipid metabolism.
,
Pubmed
,
Xenbase
Verdoorn,
Excitatory amino acid receptors expressed in Xenopus oocytes: agonist pharmacology.
1988,
Pubmed
,
Xenbase
Verdoorn,
Rat brain N-methyl-D-aspartate receptors expressed in Xenopus oocytes.
1987,
Pubmed
,
Xenbase
Vincent,
The effects of aniracetam (Ro 13-5057) on the enhancement and protection of memory.
1985,
Pubmed
