Mech Dev 2000 Mar 01;911-2:227-35. doi: 10.1016/s0925-4773(99)00303-2.

Regulation of early expression of Dlx3, a Xenopus anti-neural factor, by beta-catenin signaling.

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The ectoderm of the pre-gastrula Xenopus embryo has previously been shown to be at least partially patterned along the dorsal-ventral axis. The early expression of the anti-neural homeodomain gene Dlx3 is localized to the ventral ectoderm by a mechanism that occurs prior to gastrulation and is independent of the Spemann organizer. The repression of Dlx3 is mediated by signaling though beta-catenin, but is probably not dependent on the induction of the Xnr3 or chordin genes by beta-catenin. We propose a model in which this early regulation of Dlx3 accounts for the pro-neural bias of dorsal ectoderm.

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Species referenced: Xenopus laevis
Genes referenced: chrd dlx3 mrc1 nodal3.1 tbxt


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