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Retinoic acid regulation of Cdx1: an indirect mechanism for retinoids and vertebral specification.
Houle M
,
Prinos P
,
Iulianella A
,
Bouchard N
,
Lohnes D
.
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Retinoic acid (RA) is required for diverse developmental programs, including vertebral specification. Both RA receptor disruption and excess RA result in homeotic transformations of the axial skeleton. These effects are believed to occur through altered expression of Hox genes, several of which have been demonstrated to be direct RA targets. Members of the cdx (caudal) homeobox gene family are also implicated in regulating Hox expression. Disruption of cdx1 results in vertebral homeotic transformations and alteration of Hox expression boundaries; similar homeosis is also observed in cdx2 heterozygotes. In Xenopus, gain or loss of Cdx function affects vertebral morphogenesis through a mechanism that also correlates with altered Hox expression. Taken together with the finding of putative Cdx binding motifs in several Hox promoters, these data strongly support a role for Cdx members in direct regulation of expression of at least some Hox genes. Most retinoid-responsive Hox genes have not been demonstrated to be direct RA targets, suggesting that intermediaries are involved. Based on these findings, we hypothesized that one or more cdx members may transduce the effects of RA on Hox transcription. Consistent with this, we present evidence that cdx1 is a direct RA target gene, suggesting an additional pathway for retinoid-dependent vertebral specification.
Abu-Abed,
Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha.
1998, Pubmed
Abu-Abed,
Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha.
1998,
Pubmed
Allenby,
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.
1993,
Pubmed
Balkan,
Transgenic indicator mice for studying activated retinoic acid receptors during development.
1992,
Pubmed
Beck,
Expression of Cdx-2 in the mouse embryo and placenta: possible role in patterning of the extra-embryonic membranes.
1995,
Pubmed
Chambon,
A decade of molecular biology of retinoic acid receptors.
1996,
Pubmed
Charité,
Transducing positional information to the Hox genes: critical interaction of cdx gene products with position-sensitive regulatory elements.
1998,
Pubmed
Chawengsaksophak,
Homeosis and intestinal tumours in Cdx2 mutant mice.
1997,
Pubmed
Cho,
Differential activation of Xenopus homeo box genes by mesoderm-inducing growth factors and retinoic acid.
1990,
Pubmed
,
Xenbase
Conlon,
Retinoic acid and pattern formation in vertebrates.
1995,
Pubmed
Dupé,
In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE).
1997,
Pubmed
Gamer,
Murine Cdx-4 bears striking similarities to the Drosophila caudal gene in its homeodomain sequence and early expression pattern.
1993,
Pubmed
Gellon,
Shaping animal body plans in development and evolution by modulation of Hox expression patterns.
1998,
Pubmed
Heyman,
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.
1992,
Pubmed
Hu,
Isolation and characterization of the murine homeobox gene Cdx-1. Regulation of expression in intestinal epithelial cells.
1993,
Pubmed
Isaacs,
Regulation of Hox gene expression and posterior development by the Xenopus caudal homologue Xcad3.
1998,
Pubmed
,
Xenbase
Iulianella,
A molecular basis for retinoic acid-induced axial truncation.
1999,
Pubmed
Iulianella,
Contribution of retinoic acid receptor gamma to retinoid-induced craniofacial and axial defects.
1997,
Pubmed
Kenyon,
The dance of the Hox genes: patterning the anteroposterior body axis of Caenorhabditis elegans.
1997,
Pubmed
Kessel,
Respecification of vertebral identities by retinoic acid.
1992,
Pubmed
Kessel,
Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid.
1991,
Pubmed
Kolm,
Xenopus hindbrain patterning requires retinoid signaling.
1997,
Pubmed
,
Xenbase
Langston,
Retinoic acid-responsive enhancers located 3' of the Hox A and Hox B homeobox gene clusters. Functional analysis.
1997,
Pubmed
Lohnes,
Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants.
1994,
Pubmed
Lohnes,
Function of retinoic acid receptor gamma in the mouse.
1993,
Pubmed
Lufkin,
High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice.
1993,
Pubmed
Maden,
Vitamin A-deficient quail embryos have half a hindbrain and other neural defects.
1996,
Pubmed
Mangelsdorf,
Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.
1992,
Pubmed
Marom,
The chicken caudal genes establish an anterior-posterior gradient by partially overlapping temporal and spatial patterns of expression.
1997,
Pubmed
Marshall,
Retinoids and Hox genes.
1996,
Pubmed
Marshall,
A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1.
1994,
Pubmed
Mendelsohn,
Retinoic acid receptor beta 2 (RAR beta 2) null mutant mice appear normal.
1994,
Pubmed
Meyer,
Mouse Cdx-1 expression during gastrulation.
1993,
Pubmed
Morrison,
In vitro and transgenic analysis of a human HOXD4 retinoid-responsive enhancer.
1996,
Pubmed
Noden,
The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues.
1983,
Pubmed
Nordeen,
Luciferase reporter gene vectors for analysis of promoters and enhancers.
1988,
Pubmed
Packer,
Expression of the murine Hoxa4 gene requires both autoregulation and a conserved retinoic acid response element.
1998,
Pubmed
Pöpperl,
Identification of a retinoic acid response element upstream of the murine Hox-4.2 gene.
1993,
Pubmed
Pownall,
eFGF, Xcad3 and Hox genes form a molecular pathway that establishes the anteroposterior axis in Xenopus.
1996,
Pubmed
,
Xenbase
Rossant,
Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.
1991,
Pubmed
Sasai,
Ectodermal patterning in vertebrate embryos.
1997,
Pubmed
,
Xenbase
Studer,
Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning.
1998,
Pubmed
Studer,
Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1.
1994,
Pubmed
Subramanian,
Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes.
1995,
Pubmed
Sucov,
Retinoic acid and retinoic acid receptors in development.
1995,
Pubmed
Taneja,
Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types.
1995,
Pubmed
Umesono,
Retinoic acid and thyroid hormone induce gene expression through a common responsive element.
1988,
Pubmed
