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XB-ART-15125
Neuroreport 1998 Mar 09;94:583-7. doi: 10.1097/00001756-199803090-00004.
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Activation of inwardly rectifying K+ channels by GABA-B receptors expressed in Xenopus oocytes.

Uezono Y , Akihara M , Kaibara M , Kawano C , Shibuya I , Ueda Y , Yanagihara N , Toyohira Y , Yamashita H , Taniyama K , Izumi F .


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In Xenopus oocytes coinjected with poly(A)+ RNA derived from the rat cerebellum and cRNAs for the cloned G protein-gated inwardly rectifying K+ channel (GIRK), GIRK1 and GIRK2, the GABA-B agonist baclofen elicited inwardly rectifying K+ currents. The inward K+ currents elicited by baclofen were inhibited by the selective GABA-B antagonists 2-OH saclofen and CGP 35348, and by the GIRK inhibitor Ba2+. In contrast, baclofen caused no currents in oocytes injected with the cerebellar poly(A)+ RNA alone, the poly(A)+ RNA and cRNA for GIRK1 or GIRK2, or only cRNAs for GIRK1 and GIRK2. These findings indicate that GABA-B receptors in the rat cerebellum were functionally expressed in Xenopus oocytes and activated the cloned GIRKs composed of GIRK1 and GIRK2 as heteromultimers.

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Species referenced: Xenopus laevis
Genes referenced: kcnj3 kcnj6