Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Differences in expression of acetylcholinesterase and collagen Q control the distribution and oligomerization of the collagen-tailed forms in fast and slow muscles.
Krejci E
,
Legay C
,
Thomine S
,
Sketelj J
,
Massoulié J
.
???displayArticle.abstract???
The collagen-tailed forms of acetylcholinesterase (AChE) are accumulated at mammalian neuromuscular junctions. The A(4), A(8), and A(12) forms are expressed differently in the rat fast and slow muscles; the sternomastoid muscle contains essentially the A(12) form at end plates, whereas the soleus muscle also contains extrajunctional A(4) and A(8) forms. We show that collagen Q (ColQ) transcripts become exclusively junctional in the adult sternomastoid but remain uniformly expressed in the soleus. By coinjecting Xenopus oocytes with AChE(T) and ColQ mRNAs, we reproduced the muscle patterns of collagen-tailed forms. The soleus contains transcripts ColQ1 and ColQ1a, whereas the sternomastoid only contains ColQ1a. Collagen-tailed AChE represents the first evidence that synaptic components involved in cholinergic transmission may be differently regulated in fast and slow muscles.
Anderson,
Aggregates of acetylcholine receptors are associated with plaques of a basal lamina heparan sulfate proteoglycan on the surface of skeletal muscle fibers.
1983, Pubmed,
Xenbase
Anderson,
Aggregates of acetylcholine receptors are associated with plaques of a basal lamina heparan sulfate proteoglycan on the surface of skeletal muscle fibers.
1983,
Pubmed
,
Xenbase
Bevan,
The distribution of alpha-bungarotoxin binding sites of mammalian skeletal muscle developing in vivo.
1977,
Pubmed
Bon,
The dependence of acetylcholinesterase aggregation at low ionic strength upon a polyanionic component.
1978,
Pubmed
Bon,
Quaternary associations of acetylcholinesterase. II. The polyproline attachment domain of the collagen tail.
1997,
Pubmed
Bon,
Quaternary associations of acetylcholinesterase. I. Oligomeric associations of T subunits with and without the amino-terminal domain of the collagen tail.
1997,
Pubmed
Brandan,
Anchorage of collagen-tailed acetylcholinesterase to the extracellular matrix is mediated by heparan sulfate proteoglycans.
1985,
Pubmed
Brandan,
Binding of the asymmetric forms of acetylcholinesterase to heparin.
1984,
Pubmed
Carson,
Distribution of acetylcholinesterase molecular forms in neural and non-neural sections of human muscle.
1979,
Pubmed
Chomczynski,
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
1987,
Pubmed
Cresnar,
Neural regulation of muscle acetylcholinesterase is exerted on the level of its mRNA.
1994,
Pubmed
Deprez,
Two heparin-binding domains are present on the collagenic tail of asymmetric acetylcholinesterase.
1995,
Pubmed
Dolenc,
Satellite cells in slow and fast rat muscles differ in respect to acetylcholinesterase regulation mechanisms they convey to their descendant myofibers during regeneration.
1994,
Pubmed
Donger,
Mutation in the human acetylcholinesterase-associated collagen gene, COLQ, is responsible for congenital myasthenic syndrome with end-plate acetylcholinesterase deficiency (Type Ic).
1998,
Pubmed
ELLMAN,
A new and rapid colorimetric determination of acetylcholinesterase activity.
1961,
Pubmed
Feng,
Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and function.
1999,
Pubmed
Fernandez,
Subcellular distribution of acetylcholinesterase asymmetric forms during postnatal development of mammalian skeletal muscle.
1984,
Pubmed
Fernandez,
Exercise selectively increases G4 AChe activity in fast-twitch muscle.
1988,
Pubmed
Hall,
Synaptic structure and development: the neuromuscular junction.
1993,
Pubmed
Hall,
Enzymatic detachment of endplate acetylcholinesterase from muscle.
1971,
Pubmed
Hall,
Multiple forms of acetylcholinesterase and their distribution in endplate and non-endplate regions of rat diaphragm muscle.
1973,
Pubmed
Jasmin,
Regulation by exercise of the pool of G4 acetylcholinesterase characterizing fast muscles: opposite effect of running training in antagonist muscles.
1990,
Pubmed
KOELLE,
A histochemical method for localizing cholinesterase activity.
1949,
Pubmed
Koenig,
Biochemical stability of the AChE molecular forms after cytochemical staining: postnatal focalization of the 16S AChE in rat muscle.
1981,
Pubmed
Krejci,
Primary structure of a collagenic tail peptide of Torpedo acetylcholinesterase: co-expression with catalytic subunit induces the production of collagen-tailed forms in transfected cells.
1991,
Pubmed
Krejci,
The mammalian gene of acetylcholinesterase-associated collagen.
1997,
Pubmed
Lai,
Neural control of the forms of acetylcholinesterase in slow mammalian muscles.
,
Pubmed
Legay,
Developmental regulation of acetylcholinesterase transcripts in the mouse diaphragm: alternative splicing and focalization.
1995,
Pubmed
Lømo,
Stimulation of denervated rat soleus muscle with fast and slow activity patterns induces different expression of acetylcholinesterase molecular forms.
1985,
Pubmed
Marsh,
An immunological study of rat acetylcholinesterase: comparison with acetylcholinesterases from other vertebrates.
1984,
Pubmed
Martin,
A synaptic localization domain in the synaptic cleft protein laminin beta 2 (s-laminin).
1995,
Pubmed
Massoulié,
Structure and functions of acetylcholinesterase and butyrylcholinesterase.
1993,
Pubmed
Moscoso,
N-CAM, 43K-rapsyn, and S-laminin mRNAs are concentrated at synaptic sites in muscle fibers.
1995,
Pubmed
Ohno,
Human endplate acetylcholinesterase deficiency caused by mutations in the collagen-like tail subunit (ColQ) of the asymmetric enzyme.
1998,
Pubmed
Peng,
Acetylcholinesterase clustering at the neuromuscular junction involves perlecan and dystroglycan.
1999,
Pubmed
,
Xenbase
Rossi,
Localization of "non-extractable" acetylcholinesterase to the vertebrate neuromuscular junction.
1993,
Pubmed
Rossi,
Transient interactions between collagen-tailed acetylcholinesterase and sulfated proteoglycans prior to immobilization on the extracellular matrix.
1996,
Pubmed
Rotundo,
Transplantation of quail collagen-tailed acetylcholinesterase molecules onto the frog neuromuscular synapse.
1997,
Pubmed
Simon,
A four-to-one association between peptide motifs: four C-terminal domains from cholinesterase assemble with one proline-rich attachment domain (PRAD) in the secretory pathway.
1998,
Pubmed
,
Xenbase
Sketelj,
Asymmetric molecular forms of acetylcholinesterase in mammalian skeletal muscles.
1985,
Pubmed
Sketelj,
Acetylcholinesterase mRNA level and synaptic activity in rat muscles depend on nerve-induced pattern of muscle activation.
1998,
Pubmed
Sketelj,
16 S acetylcholinesterase in endplate-free regions of developing rat diaghragm.
1980,
Pubmed
Sketelj,
Attachment of acetylcholinesterase to structures of the motor endplate.
1979,
Pubmed
Sketelj,
Influence of denervation on the molecular forms of junctional and extrajunctional acetylcholinesterase in fast and slow muscles of the rat.
1992,
Pubmed
Vigny,
Interactions of asymmetric forms of acetylcholinesterase with basement membrane components.
1983,
Pubmed
Vigny,
The motor end-plate specific form of acetylcholinesterase: appearance during embryogenesis and re-innervation of rat muscle.
1976,
Pubmed
