Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Proc Natl Acad Sci U S A
1991 Dec 15;8824:11383-7.
Show Gene links
Show Anatomy links
Premature termination of transcription from the P1 promoter of the mouse c-myc gene.
Wright S
,
Mirels LF
,
Calayag MC
,
Bishop JM
.
???displayArticle.abstract???
Modulation of transcriptional elongation within the c-myc gene is thought to play a major role in determining levels of c-myc mRNA in both normal and tumor cells. A discrete site of blockage to transcriptional elongation has previously been localized at the 3' end of exon 1 of the mouse and human c-myc genes. We here identify an additional site of transcriptional attenuation that is located between the P1 and P2 promoters of the c-myc gene and that mediates premature termination of transcripts initiating from the P1 promoter. A 95-nucleotide DNA fragment derived from this region prematurely terminated transcription when placed downstream from the promoter of the H-2Kbm1 gene and assayed by expression in Xenopus oocytes. We also show that the previously identified attenuation signal in exon 1 of the mouse c-myc gene can mediate premature termination of P1-initiated transcripts. Premature termination of P1-initiated transcripts presumably increases transcription from the downstream P2 promoter; aberrant regulation of this termination may explain the increased use of the P1 promoter that is characteristic of certain tumors in which myc is overexpressed.
Alitalo,
Oncogene amplification in tumor cells.
1986, Pubmed
Alitalo,
Oncogene amplification in tumor cells.
1986,
Pubmed
Barik,
An antitermination protein engages the elongating transcription apparatus at a promoter-proximal recognition site.
1987,
Pubmed
Bender,
Differential expression of c-myb mRNA in murine B lymphomas by a block to transcription elongation.
1987,
Pubmed
Bentley,
Accurate, TATA box-dependent polymerase III transcription from promoters of the c-myc gene in injected Xenopus oocytes.
1989,
Pubmed
,
Xenbase
Bentley,
Sequence requirements for premature termination of transcription in the human c-myc gene.
1988,
Pubmed
,
Xenbase
Bentley,
A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells.
,
Pubmed
Cesarman,
Mutations in the first exon are associated with altered transcription of c-myc in Burkitt lymphoma.
1987,
Pubmed
Chen,
Identification and characterization of transcriptional arrest sites in exon 1 of the human adenosine deaminase gene.
1990,
Pubmed
,
Xenbase
Cole,
The myc oncogene: its role in transformation and differentiation.
1986,
Pubmed
Cory,
Activation of cellular oncogenes in hemopoietic cells by chromosome translocation.
1986,
Pubmed
Cullen,
Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis.
,
Pubmed
Dani,
Increased rate of degradation of c-myc mRNA in interferon-treated Daudi cells.
1985,
Pubmed
Dani,
Extreme instability of myc mRNA in normal and transformed human cells.
1984,
Pubmed
de Vegvar,
3' end formation of U1 snRNA precursors is coupled to transcription from snRNA promoters.
1986,
Pubmed
Eick,
Transcriptional arrest within the first exon is a fast control mechanism in c-myc gene expression.
1986,
Pubmed
Eick,
Transcription of c-myc in human mononuclear cells is regulated by an elongation block.
1987,
Pubmed
Einat,
Close link between reduction of c-myc expression by interferon and, G0/G1 arrest.
,
Pubmed
Faus,
Structural and functional properties of the segments of lambda cro mRNA that interact with transcription termination factor Rho.
1990,
Pubmed
Fort,
Regulation of c-fos gene expression in hamster fibroblasts: initiation and elongation of transcription and mRNA degradation.
1987,
Pubmed
Gottlieb,
The RNA binding protein La influences both the accuracy and the efficiency of RNA polymerase III transcription in vitro.
1989,
Pubmed
Gottlieb,
Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III.
1989,
Pubmed
Grayhack,
Phage lambda gene Q antiterminator recognizes RNA polymerase near the promoter and accelerates it through a pause site.
1985,
Pubmed
Gurdon,
The use of Xenopus oocytes for the expression of cloned genes.
1983,
Pubmed
,
Xenbase
Hann,
A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas.
1988,
Pubmed
,
Xenbase
Hernandez,
Elements required for transcription initiation of the human U2 snRNA gene coincide with elements required for snRNA 3' end formation.
1988,
Pubmed
Horwitz,
An elongation control particle containing the N gene transcriptional antitermination protein of bacteriophage lambda.
1987,
Pubmed
Kuhn,
Specific interaction of the murine transcription termination factor TTF I with class-I RNA polymerases.
1990,
Pubmed
Lazinski,
Sequence-specific recognition of RNA hairpins by bacteriophage antiterminators requires a conserved arginine-rich motif.
1989,
Pubmed
McStay,
An RNA polymerase I termination site can stimulate the adjacent ribosomal gene promoter by two distinct mechanisms in Xenopus laevis.
1990,
Pubmed
,
Xenbase
McStay,
A DNA-binding protein is required for termination of transcription by RNA polymerase I in Xenopus laevis.
1990,
Pubmed
,
Xenbase
Middleton,
Premature termination of transcription can be induced on an injected alpha-tubulin gene in Xenopus oocytes.
1990,
Pubmed
,
Xenbase
Miller,
A cis-acting element in the promoter region of the murine c-myc gene is necessary for transcriptional block.
1989,
Pubmed
Nepveu,
Contributions of transcriptional and post-transcriptional mechanisms to the regulation of c-myc expression in mouse erythroleukemia cells.
1987,
Pubmed
Nepveu,
Intragenic pausing and anti-sense transcription within the murine c-myc locus.
1986,
Pubmed
Nepveu,
Alternative modes of c-myc regulation in growth factor-stimulated and differentiating cells.
1987,
Pubmed
Pfleiderer,
An undecamer DNA sequence directs termination of human ribosomal gene transcription.
1990,
Pubmed
Platt,
Transcription termination and the regulation of gene expression.
1986,
Pubmed
Proudfoot,
Transcriptional interference and termination between duplicated alpha-globin gene constructs suggests a novel mechanism for gene regulation.
,
Pubmed
Ramamurthy,
Sequence requirements for transcriptional arrest in exon 1 of the murine adenosine deaminase gene.
1990,
Pubmed
,
Xenbase
Schwab,
Amplification of cellular oncogenes: a predictor of clinical outcome in human cancer.
1990,
Pubmed
Spandidos,
Transfer of human globin genes to erythroleukemic mouse cells.
1982,
Pubmed
Spencer,
The block to transcription elongation is promoter dependent in normal and Burkitt's lymphoma c-myc alleles.
1990,
Pubmed
,
Xenbase
Taub,
A novel alteration in the structure of an activated c-myc gene in a variant t(2;8) Burkitt lymphoma.
1984,
Pubmed
Taub,
Activation and somatic mutation of the translocated c-myc gene in burkitt lymphoma cells.
1984,
Pubmed
Varmus,
The molecular genetics of cellular oncogenes.
1984,
Pubmed
Watson,
A transcriptional arrest mechanism involved in controlling constitutive levels of mouse c-myb mRNA.
1988,
Pubmed
Wright,
DNA sequences that mediate attenuation of transcription from the mouse protooncogene myc.
1989,
Pubmed
