XB-ART-45907
Cold Spring Harb Perspect Biol
2013 Jan 01;51:a007955. doi: 10.1101/cshperspect.a007955.
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Wnt signaling in vertebrate axis specification.
Hikasa H
,
Sokol SY
.
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The Wnt pathway is a major embryonic signaling pathway that controls cell proliferation, cell fate, and body-axis determination in vertebrate embryos. Soon after egg fertilization, Wnt pathway components play a role in microtubule-dependent dorsoventral axis specification. Later in embryogenesis, another conserved function of the pathway is to specify the anteroposterior axis. The dual role of Wnt signaling in Xenopus and zebrafish embryos is regulated at different developmental stages by distinct sets of Wnt target genes. This review highlights recent progress in the discrimination of different signaling branches and the identification of specific pathway targets during vertebrate axial development.
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References [+] :
Aamar,
Xenopus Meis3 protein forms a hindbrain-inducing center by activating FGF/MAP kinase and PCP pathways.
2004, Pubmed,
Xenbase
Aamar, Xenopus Meis3 protein forms a hindbrain-inducing center by activating FGF/MAP kinase and PCP pathways. 2004, Pubmed , Xenbase
Abu-Remaileh, Oct-3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/β-catenin signalling. 2010, Pubmed , Xenbase
Akkers, A hierarchy of H3K4me3 and H3K27me3 acquisition in spatial gene regulation in Xenopus embryos. 2009, Pubmed , Xenbase
Amaya, FGF signalling in the early specification of mesoderm in Xenopus. 1993, Pubmed , Xenbase
Amaya, Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. 1991, Pubmed , Xenbase
Andreazzoli, Cloning and expression of noz1, a zebrafish zinc finger gene related to Drosophila nocA. 2001, Pubmed
Angers, Proximal events in Wnt signal transduction. 2009, Pubmed
Axelrod, Progress and challenges in understanding planar cell polarity signaling. 2009, Pubmed
Beck, The role of Cdx genes in the gut and in axial development. 2010, Pubmed
Behrens, Functional interaction of beta-catenin with the transcription factor LEF-1. 1996, Pubmed , Xenbase
Bellipanni, Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectoderm. 2006, Pubmed
Bilic, Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. 2007, Pubmed
Blumberg, Organizer-specific homeobox genes in Xenopus laevis embryos. 1991, Pubmed , Xenbase
Blythe, beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2. 2010, Pubmed , Xenbase
Bouwmeester, Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. 1996, Pubmed , Xenbase
Brannon, A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. 1997, Pubmed , Xenbase
Brantjes, All Tcf HMG box transcription factors interact with Groucho-related co-repressors. 2001, Pubmed
Bromley, Identification and characterisation of the posteriorly-expressed Xenopus neurotrophin receptor homolog genes fullback and fullback-like. 2004, Pubmed , Xenbase
Brott, Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins. 2002, Pubmed , Xenbase
Burks, FGF signalling modulates transcriptional repression by Xenopus groucho-related-4. 2009, Pubmed , Xenbase
Candia, Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. 1997, Pubmed , Xenbase
Cavallo, Drosophila Tcf and Groucho interact to repress Wingless signalling activity. 1998, Pubmed
Cha, Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation. 2008, Pubmed , Xenbase
Cho, Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid. 1991, Pubmed , Xenbase
Choe, Meis cofactors control HDAC and CBP accessibility at Hox-regulated promoters during zebrafish embryogenesis. 2009, Pubmed
Christian, Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis. 1991, Pubmed , Xenbase
Christian, Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus. 1993, Pubmed , Xenbase
Christian, Isolation of cDNAs partially encoding four Xenopus Wnt-1/int-1-related proteins and characterization of their transient expression during embryonic development. 1991, Pubmed , Xenbase
Chung, Establishment of the dorsal/ventral polarity of the amphibian embryo: use of ultraviolet irradiation and egg rotation as probes. 1980, Pubmed , Xenbase
Chung, Screening of FGF target genes in Xenopus by microarray: temporal dissection of the signalling pathway using a chemical inhibitor. 2004, Pubmed , Xenbase
Clevers, Wnt/beta-catenin signaling in development and disease. 2006, Pubmed
Cliffe, A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling. 2003, Pubmed
Cole, Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. 2008, Pubmed
Conlon, A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. 1994, Pubmed
Cook, Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C. 1996, Pubmed
Cox, Caudalization of neural fate by tissue recombination and bFGF. 1995, Pubmed , Xenbase
Daniels, Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. 2005, Pubmed
Darken, Axis induction by wnt signaling: Target promoter responsiveness regulates competence. 2001, Pubmed , Xenbase
Davidson, cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. 2003, Pubmed
Deardorff, Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis. 1998, Pubmed , Xenbase
De Robertis, Dorsal-ventral patterning and neural induction in Xenopus embryos. 2004, Pubmed , Xenbase
Doniach, Planar induction of anteroposterior pattern in the developing central nervous system of Xenopus laevis. 1992, Pubmed , Xenbase
Dorsky, Two tcf3 genes cooperate to pattern the zebrafish brain. 2003, Pubmed
Dorsky, Maternal and embryonic expression of zebrafish lef1. 1999, Pubmed , Xenbase
Dorsky, A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development. 2002, Pubmed
Elkouby, Mesodermal Wnt signaling organizes the neural plate via Meis3. 2010, Pubmed , Xenbase
Epstein, Patterning of the embryo along the anterior-posterior axis: the role of the caudal genes. 1997, Pubmed , Xenbase
Erter, Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo. 2001, Pubmed , Xenbase
Faas, Overlapping functions of Cdx1, Cdx2, and Cdx4 in the development of the amphibian Xenopus tropicalis. 2009, Pubmed , Xenbase
Fan, Wnt signaling and transcriptional control of Siamois in Xenopus embryos. 1998, Pubmed , Xenbase
Fan, A role for Siamois in Spemann organizer formation. 1997, Pubmed , Xenbase
Fekany, The zebrafish bozozok locus encodes Dharma, a homeodomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures. 1999, Pubmed
Feldman, Zebrafish organizer development and germ-layer formation require nodal-related signals. 1998, Pubmed
Fossat, Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo. 2011, Pubmed
Frazzetto, Xenopus marginal coil (Xmc), a novel FGF inducible cytosolic coiled-coil protein regulating gastrulation movements. 2002, Pubmed , Xenbase
Fuentealba, Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal. 2007, Pubmed , Xenbase
Fujisue, Occurrence of dorsal axis-inducing activity around the vegetal pole of an uncleaved Xenopus egg and displacement to the equatorial region by cortical rotation. 1993, Pubmed , Xenbase
Gao, Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. 2011, Pubmed
Garcia-Morales, Frizzled-10 promotes sensory neuron development in Xenopus embryos. 2009, Pubmed , Xenbase
Gawantka, Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1. 1995, Pubmed , Xenbase
Glinka, Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. 1998, Pubmed , Xenbase
Gradl, Functional diversity of Xenopus lymphoid enhancer factor/T-cell factor transcription factors relies on combinations of activating and repressing elements. 2002, Pubmed , Xenbase
Gribble, Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression. 2009, Pubmed
Grigoryan, Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. 2008, Pubmed
Grumolato, Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. 2010, Pubmed
Haegel, Lack of beta-catenin affects mouse development at gastrulation. 1995, Pubmed
Hamilton, Difference in XTcf-3 dependency accounts for change in response to beta-catenin-mediated Wnt signalling in Xenopus blastula. 2001, Pubmed , Xenbase
Haremaki, Integration of multiple signal transducing pathways on Fgf response elements of the Xenopus caudal homologue Xcad3. 2003, Pubmed , Xenbase
Harland, Formation and function of Spemann's organizer. 1997, Pubmed
Hartmann, A Wnt canon orchestrating osteoblastogenesis. 2006, Pubmed
Hata, OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. 2000, Pubmed , Xenbase
Heasman, Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos. 1994, Pubmed , Xenbase
Heasman, Beta-catenin signaling activity dissected in the early Xenopus embryo: a novel antisense approach. 2000, Pubmed , Xenbase
Heisenberg, Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. 2000, Pubmed
Heisenberg, A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. 2001, Pubmed
Hikasa, The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling. 2002, Pubmed , Xenbase
Hikasa, Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2. 2011, Pubmed , Xenbase
Hikasa, Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification. 2010, Pubmed , Xenbase
Hilton, VegT activation of the early zygotic gene Xnr5 requires lifting of Tcf-mediated repression in the Xenopus blastula. 2003, Pubmed , Xenbase
Holowacz, FGF is required for posterior neural patterning but not for neural induction. 1999, Pubmed , Xenbase
Holowacz, Cortical cytoplasm, which induces dorsal axis formation in Xenopus, is inactivated by UV irradiation of the oocyte. 1993, Pubmed , Xenbase
Holstein, Wnt signaling in cnidarians. 2008, Pubmed
Hong, Fgf8a induces neural crest indirectly through the activation of Wnt8 in the paraxial mesoderm. 2008, Pubmed , Xenbase
Hoppler, BMP-2/-4 and Wnt-8 cooperatively pattern the Xenopus mesoderm. 1998, Pubmed , Xenbase
Hoppler, Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos. 1996, Pubmed , Xenbase
Houliston, Microtubules and cytoplasmic reorganization in the frog egg. 1992, Pubmed , Xenbase
Houston, Repression of organizer genes in dorsal and ventral Xenopus cells mediated by maternal XTcf3. 2002, Pubmed , Xenbase
Huber, Nuclear localization of beta-catenin by interaction with transcription factor LEF-1. 1996, Pubmed , Xenbase
Huelsken, Requirement for beta-catenin in anterior-posterior axis formation in mice. 2000, Pubmed
Hufton, Genomic analysis of Xenopus organizer function. 2006, Pubmed , Xenbase
Imai, The homeobox genes vox and vent are redundant repressors of dorsal fates in zebrafish. 2001, Pubmed , Xenbase
Isaacs, Regulation of Hox gene expression and posterior development by the Xenopus caudal homologue Xcad3. 1998, Pubmed , Xenbase
Ishikawa, Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo. 2003, Pubmed
Ishitani, The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. 1999, Pubmed , Xenbase
Itasaki, Crosstalk between Wnt and bone morphogenic protein signaling: a turbulent relationship. 2010, Pubmed
Itoh, Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction. 2000, Pubmed , Xenbase
Itoh, Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin. 1998, Pubmed , Xenbase
Itoh, Graded amounts of Xenopus dishevelled specify discrete anteroposterior cell fates in prospective ectoderm. 1997, Pubmed , Xenbase
Itoh, Specific modulation of ectodermal cell fates in Xenopus embryos by glycogen synthase kinase. 1995, Pubmed , Xenbase
Itoh, Centrosomal localization of Diversin and its relevance to Wnt signaling. 2009, Pubmed , Xenbase
Itoh, A role for Xenopus Frizzled 8 in dorsal development. 1998, Pubmed , Xenbase
Itoh, Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling. 2005, Pubmed , Xenbase
Jesuthasan, Dynamic microtubules and specification of the zebrafish embryonic axis. 1997, Pubmed
Jho, Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. 2002, Pubmed
Kanei-Ishii, Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. 2004, Pubmed
Karaulanov, Transcriptional regulation of BMP4 synexpression in transgenic Xenopus. 2004, Pubmed , Xenbase
Kawakami, WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo. 2001, Pubmed
Keenan, FGF signal transduction and the regulation of Cdx gene expression. 2006, Pubmed , Xenbase
Kelly, Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways. 1995, Pubmed , Xenbase
Kelly, Maternally controlled (beta)-catenin-mediated signaling is required for organizer formation in the zebrafish. 2000, Pubmed
Kessler, Siamois is required for formation of Spemann's organizer. 1997, Pubmed , Xenbase
Kiecker, A morphogen gradient of Wnt/beta-catenin signalling regulates anteroposterior neural patterning in Xenopus. 2001, Pubmed , Xenbase
Kikuchi, Selective activation mechanisms of Wnt signaling pathways. 2009, Pubmed
Kilian, The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. 2003, Pubmed
Kim, Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation. 2010, Pubmed , Xenbase
Kim, Repressor activity of Headless/Tcf3 is essential for vertebrate head formation. 2000, Pubmed
Klein, A molecular mechanism for the effect of lithium on development. 1996, Pubmed , Xenbase
Kolm, Regulation of the Xenopus labial homeodomain genes, HoxA1 and HoxD1: activation by retinoids and peptide growth factors. 1995, Pubmed , Xenbase
Komiya, Wnt signal transduction pathways. 2008, Pubmed
König, The HMG-box transcription factor XTcf-4 demarcates the forebrain-midbrain boundary. 2000, Pubmed , Xenbase
Koos, The nieuwkoid gene characterizes and mediates a Nieuwkoop-center-like activity in the zebrafish. 1998, Pubmed
Kouzarides, Chromatin modifications and their function. 2007, Pubmed
Krauss, Expression of four zebrafish wnt-related genes during embryogenesis. 1992, Pubmed , Xenbase
Ku, Xwnt-11: a maternally expressed Xenopus wnt gene. 1993, Pubmed , Xenbase
Kudoh, Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains. 2004, Pubmed
Labbé, Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways. 2000, Pubmed , Xenbase
Ladher, Xom: a Xenopus homeobox gene that mediates the early effects of BMP-4. 1996, Pubmed , Xenbase
Lamb, Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern. 1995, Pubmed , Xenbase
Larabell, Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathway. 1997, Pubmed , Xenbase
Laurent, The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann's organizer. 1997, Pubmed , Xenbase
Lee, Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization of beta-catenin/Arm and stimulation of target gene expression. 2009, Pubmed
Lekven, Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning. 2001, Pubmed
Lemaire, Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis. 1995, Pubmed , Xenbase
Leung, Direct binding of Lef1 to sites in the boz promoter may mediate pre-midblastula-transition activation of boz expression. 2003, Pubmed
Leyns, Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. 1997, Pubmed , Xenbase
Li, Chromatin modification and epigenetic reprogramming in mammalian development. 2002, Pubmed
Li, Cyclic expression of esr9 gene in Xenopus presomitic mesoderm. 2003, Pubmed , Xenbase
Li, Gene profiling of Frizzled-1 and Frizzled-2 signaling: expression of G-protein-coupled receptor chimeras in mouse F9 teratocarcinoma embryonal cells. 2004, Pubmed
Li, The posteriorizing gene Gbx2 is a direct target of Wnt signalling and the earliest factor in neural crest induction. 2009, Pubmed , Xenbase
Lin, Requirement for Wnt and FGF signaling in Xenopus tadpole tail regeneration. 2008, Pubmed , Xenbase
Lin, Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement. 2010, Pubmed
Liu, beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation. 1999, Pubmed , Xenbase
Liu, Distinct roles for Xenopus Tcf/Lef genes in mediating specific responses to Wnt/beta-catenin signalling in mesoderm development. 2005, Pubmed , Xenbase
Liu, Requirement for Wnt3 in vertebrate axis formation. 1999, Pubmed
Lo, Phosphorylation by the beta-catenin/MAPK complex promotes 14-3-3-mediated nuclear export of TCF/POP-1 in signal-responsive cells in C. elegans. 2004, Pubmed
Louie, Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1. 2009, Pubmed , Xenbase
Lu, Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. 2004, Pubmed
Lupo, Induction and patterning of the telencephalon in Xenopus laevis. 2002, Pubmed , Xenbase
Lyman Gingerich, hecate, a zebrafish maternal effect gene, affects dorsal organizer induction and intracellular calcium transient frequency. 2005, Pubmed
MacDonald, Wnt/beta-catenin signaling: components, mechanisms, and diseases. 2009, Pubmed , Xenbase
Maeda, Xmsx-1 modifies mesodermal tissue pattern along dorsoventral axis in Xenopus laevis embryo. 1997, Pubmed , Xenbase
Maegawa, FGF signaling is required for {beta}-catenin-mediated induction of the zebrafish organizer. 2006, Pubmed
Majumdar, Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. 2003, Pubmed
Maniatis, A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways. 1999, Pubmed
Mao, Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. 2002, Pubmed
Marazzi, Msx2 is a transcriptional regulator in the BMP4-mediated programmed cell death pathway. 1997, Pubmed
Marchal, BMP inhibition initiates neural induction via FGF signaling and Zic genes. 2009, Pubmed , Xenbase
Marlow, NULL 2010, Pubmed
Martin, Wnt signaling and the evolution of embryonic posterior development. 2009, Pubmed
Martinez, FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression. 1999, Pubmed
Massague, Integration of Smad and MAPK pathways: a link and a linker revisited. 2003, Pubmed
Mathers, The Rx homeobox gene is essential for vertebrate eye development. 1997, Pubmed , Xenbase
McGrew, Wnt and FGF pathways cooperatively pattern anteroposterior neural ectoderm in Xenopus. 1997, Pubmed , Xenbase
McKendry, LEF-1/TCF proteins mediate wnt-inducible transcription from the Xenopus nodal-related 3 promoter. 1997, Pubmed , Xenbase
McMahon, Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis. 1989, Pubmed , Xenbase
Melby, Patterning the early zebrafish by the opposing actions of bozozok and vox/vent. 2000, Pubmed , Xenbase
Melby, Regulation of dorsal gene expression in Xenopus by the ventralizing homeodomain gene Vox. 1999, Pubmed , Xenbase
Meneghini, MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. 1999, Pubmed
Merrill, Tcf3: a transcriptional regulator of axis induction in the early embryo. 2004, Pubmed
Mikels, Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. 2006, Pubmed
Mir, FoxI1e activates ectoderm formation and controls cell position in the Xenopus blastula. 2007, Pubmed , Xenbase
Mizuno, Removal of vegetal yolk causes dorsal deficencies and impairs dorsal-inducing ability of the yolk cell in zebrafish. 1999, Pubmed
Molenaar, Differential expression of the HMG box transcription factors XTcf-3 and XLef-1 during early xenopus development. 1998, Pubmed , Xenbase
Molenaar, XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. 1996, Pubmed , Xenbase
Moon, Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis. 1993, Pubmed , Xenbase
Moon, From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in Xenopus. 1998, Pubmed , Xenbase
Mukhopadhyay, Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. 2001, Pubmed , Xenbase
Nakamura, Nlz1/Znf703 acts as a repressor of transcription. 2008, Pubmed
Nelson, Convergence of Wnt, beta-catenin, and cadherin pathways. 2004, Pubmed
Nentwich, Downstream of FGF during mesoderm formation in Xenopus: the roles of Elk-1 and Egr-1. 2009, Pubmed , Xenbase
Ng, Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription. 2008, Pubmed , Xenbase
Nguyen, Tcf3 governs stem cell features and represses cell fate determination in skin. 2006, Pubmed
Nishita, Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration. 2006, Pubmed
Nishita, Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer. 2000, Pubmed , Xenbase
Nishita, Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization. 2010, Pubmed
Nojima, Syntabulin, a motor protein linker, controls dorsal determination. 2010, Pubmed
Nojima, Genetic evidence for involvement of maternally derived Wnt canonical signaling in dorsal determination in zebrafish. 2004, Pubmed
Northrop, Dorsal-ventral differences in Xcad-3 expression in response to FGF-mediated induction in Xenopus. 1994, Pubmed , Xenbase
Ober, Signals from the yolk cell induce mesoderm, neuroectoderm, the trunk organizer, and the notochord in zebrafish. 1999, Pubmed
Olson, Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. 2006, Pubmed
Onichtchouk, The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controlling [correction of controling] dorsoventral patterning of Xenopus mesoderm. 1996, Pubmed , Xenbase
Osada, Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis. 1999, Pubmed , Xenbase
Pera, Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. 2003, Pubmed , Xenbase
Perantoni, Renal development: perspectives on a Wnt-dependent process. 2003, Pubmed
Petersen, Wnt signaling and the polarity of the primary body axis. 2009, Pubmed
Phillips, A new look at TCF and beta-catenin through the lens of a divergent C. elegans Wnt pathway. 2009, Pubmed
Pillemer, The Xcad-2 gene can provide a ventral signal independent of BMP-4. 1998, Pubmed , Xenbase
Pilon, Cdx4 is a direct target of the canonical Wnt pathway. 2006, Pubmed
Ramel, Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox. 2004, Pubmed , Xenbase
Ramel, WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation. 2005, Pubmed
Rauch, Wnt5 is required for tail formation in the zebrafish embryo. 1997, Pubmed
Rocheleau, WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans. 1999, Pubmed
Rocheleau, Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. 1997, Pubmed
Roël, Lef-1 and Tcf-3 transcription factors mediate tissue-specific Wnt signaling during Xenopus development. 2002, Pubmed , Xenbase
Roël, Tcf-1 expression during Xenopus development. 2003, Pubmed , Xenbase
Roose, The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. 1998, Pubmed , Xenbase
Rothbächer, Functional conservation of the Wnt signaling pathway revealed by ectopic expression of Drosophila dishevelled in Xenopus. 1995, Pubmed , Xenbase
Ryu, Regulation of dharma/bozozok by the Wnt pathway. 2001, Pubmed
Sander, The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning. 2007, Pubmed , Xenbase
Sapkota, Balancing BMP signaling through integrated inputs into the Smad1 linker. 2007, Pubmed , Xenbase
Sasai, The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements. 2004, Pubmed , Xenbase
Sasai, Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes. 1994, Pubmed , Xenbase
Sato, Wnt5a regulates distinct signalling pathways by binding to Frizzled2. 2010, Pubmed
Sato, Localized and inducible expression of Xenopus-posterior (Xpo), a novel gene active in early frog embryos, encoding a protein with a 'CCHC' finger domain. 1991, Pubmed , Xenbase
Satoh, Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling. 2004, Pubmed
Schambony, Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway. 2007, Pubmed , Xenbase
Scharf, Determination of the dorsal-ventral axis in eggs of Xenopus laevis: complete rescue of uv-impaired eggs by oblique orientation before first cleavage. 1980, Pubmed , Xenbase
Schedl, Cross-talk in kidney development. 2000, Pubmed
Schier, Molecular genetics of axis formation in zebrafish. 2005, Pubmed
Schmidt, Regulation of dorsal-ventral patterning: the ventralizing effects of the novel Xenopus homeobox gene Vox. 1996, Pubmed , Xenbase
Schneider, Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos. 1996, Pubmed , Xenbase
Schohl, Beta-catenin, MAPK and Smad signaling during early Xenopus development. 2002, Pubmed , Xenbase
Schroeder, Spatially regulated translation in embryos: asymmetric expression of maternal Wnt-11 along the dorsal-ventral axis in Xenopus. 1999, Pubmed , Xenbase
Schwarz-Romond, The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. 2002, Pubmed , Xenbase
Shibata, Systematic screening and expression analysis of the head organizer genes in Xenopus embryos. 2001, Pubmed , Xenbase
Shibata, Xenopus crescent encoding a Frizzled-like domain is expressed in the Spemann organizer and pronephros. 2000, Pubmed , Xenbase
Shibata, Role of crescent in convergent extension movements by modulating Wnt signaling in early Xenopus embryogenesis. 2005, Pubmed , Xenbase
Shibata, A role of D domain-related proteins in differentiation and migration of embryonic cells in Xenopus laevis. 2008, Pubmed , Xenbase
Shimizu, Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue. 2006, Pubmed
Shimizu, Interaction of Wnt and caudal-related genes in zebrafish posterior body formation. 2005, Pubmed
Smith, Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center. 1991, Pubmed , Xenbase
Smith, Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. 1992, Pubmed , Xenbase
Smith, A nodal-related gene defines a physical and functional domain within the Spemann organizer. 1995, Pubmed , Xenbase
Sokol, Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. 1995, Pubmed , Xenbase
Sokol, A role for Wnts in morpho-genesis and tissue polarity. 2000, Pubmed
Sokol, Mesoderm formation in Xenopus ectodermal explants overexpressing Xwnt8: evidence for a cooperating signal reaching the animal pole by gastrulation. 1993, Pubmed , Xenbase
Sokol, Injected Wnt RNA induces a complete body axis in Xenopus embryos. 1991, Pubmed , Xenbase
Sokol, Analysis of Dishevelled signalling pathways during Xenopus development. 1996, Pubmed , Xenbase
Sokol, Wnt signaling and dorso-ventral axis specification in vertebrates. 1999, Pubmed
Sokol, Interaction of Wnt and activin in dorsal mesoderm induction in Xenopus. 1992, Pubmed , Xenbase
Sokol, Wnt signaling through T-cell factor phosphorylation. 2011, Pubmed
Spiegelman, Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor. 2000, Pubmed
Standley, Maternal XTcf1 and XTcf4 have distinct roles in regulating Wnt target genes. 2006, Pubmed , Xenbase
Sumanas, The putative wnt receptor Xenopus frizzled-7 functions upstream of beta-catenin in vertebrate dorsoventral mesoderm patterning. 2000, Pubmed , Xenbase
Suri, Xema, a foxi-class gene expressed in the gastrula stage Xenopus ectoderm, is required for the suppression of mesendoderm. 2005, Pubmed , Xenbase
Suzuki, Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4. 1997, Pubmed , Xenbase
Tada, Noncanonical Wnt/PCP signaling during vertebrate gastrulation. 2009, Pubmed , Xenbase
Taelman, Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes. 2010, Pubmed , Xenbase
Taira, Role of the LIM class homeodomain protein Xlim-1 in neural and muscle induction by the Spemann organizer in Xenopus. 1994, Pubmed , Xenbase
Takada, Wnt-3a regulates somite and tailbud formation in the mouse embryo. 1994, Pubmed
Takahashi, Two novel nodal-related genes initiate early inductive events in Xenopus Nieuwkoop center. 2000, Pubmed , Xenbase
Takao, Beta-catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells. 2007, Pubmed
Tao, Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos. 2005, Pubmed , Xenbase
Thorpe, nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish development. 2004, Pubmed
Torres, Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. 1996, Pubmed , Xenbase
Tucker, The cutting-edge of mammalian development; how the embryo makes teeth. 2004, Pubmed
Ulrich, Slb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation. 2003, Pubmed
van Amerongen, Towards an integrated view of Wnt signaling in development. 2009, Pubmed
van Amerongen, Frat is dispensable for canonical Wnt signaling in mammals. 2005, Pubmed , Xenbase
van den Akker, Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation. 2002, Pubmed
van de Wetering, Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. 1997, Pubmed
Veien, Expression pattern of zebrafish tcf7 suggests unexplored domains of Wnt/beta-catenin activity. 2005, Pubmed
Villanueva, Posteriorization by FGF, Wnt, and retinoic acid is required for neural crest induction. 2002, Pubmed , Xenbase
von Bubnoff, The Xenopus laevis homeobox gene Xgbx-2 is an early marker of anteroposterior patterning in the ectoderm. 1996, Pubmed , Xenbase
von Dassow, Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene. 1993, Pubmed , Xenbase
Wang, Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. 1997, Pubmed , Xenbase
Wei, HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis. 2007, Pubmed
Weidinger, The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning. 2005, Pubmed
Wheeler, Two novel Xenopus frizzled genes expressed in developing heart and brain. 1999, Pubmed , Xenbase
Willert, A transcriptional response to Wnt protein in human embryonic carcinoma cells. 2002, Pubmed
Wu, A quest for the mechanism regulating global planar cell polarity of tissues. 2009, Pubmed
Xu, Setdb2 restricts dorsal organizer territory and regulates left-right asymmetry through suppressing fgf8 activity. 2010, Pubmed
Xu, Regulation of protein stability by GSK3 mediated phosphorylation. 2009, Pubmed
Yamaguchi, Marked Alteration at Midblastula Transition in the Effect of Lithium on Formation of the Larval Body Pattern of Xenopus laevis: (midblastula transition/LiCl/pattern formation/half-egg fragment/Xenopus laevis). 1989, Pubmed , Xenbase
Yamaguchi, A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. 1999, Pubmed
Yamamoto, Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF. 2005, Pubmed , Xenbase
Yamanaka, A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner. 1998, Pubmed , Xenbase
Yanagawa, The dishevelled protein is modified by wingless signaling in Drosophila. 1995, Pubmed
Yang, Beta-catenin/Tcf-regulated transcription prior to the midblastula transition. 2002, Pubmed , Xenbase
Yokoyama, Initiation of limb regeneration: the critical steps for regenerative capacity. 2008, Pubmed , Xenbase
Yost, GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. 1998, Pubmed , Xenbase
Young, Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. 2009, Pubmed
Young, Hox, Cdx, and anteroposterior patterning in the mouse embryo. 2009, Pubmed
Zeng, The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. 1997, Pubmed , Xenbase
Zhang, The beta-catenin/VegT-regulated early zygotic gene Xnr5 is a direct target of SOX3 regulation. 2003, Pubmed , Xenbase
Zhou, Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. 2004, Pubmed
Znosko, Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development. 2010, Pubmed