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While kidney donations stagnate, the number of people in need of kidney transplants continues to grow. Although transplanting culture-grown organs is years away, pursuing the engineering of the kidney de novo is a valid means of closing the gap between the supply and demand of kidneys for transplantation. The structural organization of a mouse kidney is similar to that of humans. Therefore, mice have traditionally served as the primary model system for the study of kidney development. The mouse is an ideal model organism for understanding the complexity of the human kidney. Nonetheless, the elaborate structure of the mammalian kidney makes the discovery of new therapies based on de novo engineered kidneys more challenging. In contrast to mammals, amphibians have a kidney that is anatomically less complex and develops faster. Given that analogous genetic networks regulate the development of mammalian and amphibian nephric organs, using embryonic kidneys of Xenopus laevis (African clawed frog) to analyze inductive cell signaling events and morphogenesis has many advantages. Pioneering work that led to the ability to generate kidney organoids from embryonic cells was carried out in Xenopus. In this review, we discuss how Xenopus can be utilized to compliment the work performed in mammalian systems to understand kidney development.
Alarcón,
A dual requirement for Iroquois genes during Xenopus kidney development.
2008, Pubmed,
Xenbase
Alarcón,
A dual requirement for Iroquois genes during Xenopus kidney development.
2008,
Pubmed
,
Xenbase
Bartkowski,
Developmental regulation and tissue distribution of the liver transcription factor LFB1 (HNF1) in Xenopus laevis.
1993,
Pubmed
,
Xenbase
Bauer,
The cleavage stage origin of Spemann's Organizer: analysis of the movements of blastomere clones before and during gastrulation in Xenopus.
1994,
Pubmed
,
Xenbase
Blankenship,
Multicellular rosette formation links planar cell polarity to tissue morphogenesis.
2006,
Pubmed
Blitz,
Biallelic genome modification in F(0) Xenopus tropicalis embryos using the CRISPR/Cas system.
2013,
Pubmed
,
Xenbase
Bohn,
Distinct molecular and morphogenetic properties of mutations in the human HNF1beta gene that lead to defective kidney development.
2003,
Pubmed
,
Xenbase
Brändli,
Towards a molecular anatomy of the Xenopus pronephric kidney.
1999,
Pubmed
,
Xenbase
Brennan,
The specification of the pronephric tubules and duct in Xenopus laevis.
1998,
Pubmed
,
Xenbase
Brennan,
The specification and growth factor inducibility of the pronephric glomus in Xenopus laevis.
1999,
Pubmed
,
Xenbase
Buisson,
Pax8 and Pax2 are specifically required at different steps of Xenopus pronephros development.
2015,
Pubmed
,
Xenbase
Caine,
Regeneration of functional pronephric proximal tubules after partial nephrectomy in Xenopus laevis.
2013,
Pubmed
,
Xenbase
Carroll,
Dynamic patterns of gene expression in the developing pronephros of Xenopus laevis.
1999,
Pubmed
,
Xenbase
Carroll,
Wilms' tumor suppressor gene is involved in the development of disparate kidney forms: evidence from expression in the Xenopus pronephros.
1996,
Pubmed
,
Xenbase
Carroll,
Synergism between Pax-8 and lim-1 in embryonic kidney development.
1999,
Pubmed
,
Xenbase
Chan,
A model system for organ engineering: transplantation of in vitro induced embryonic kidney.
1999,
Pubmed
,
Xenbase
Chi,
Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis.
2009,
Pubmed
DeLay,
Technique to Target Microinjection to the Developing Xenopus Kidney.
2016,
Pubmed
,
Xenbase
Demartis,
Cloning and developmental expression of LFB3/HNF1 beta transcription factor in Xenopus laevis.
1994,
Pubmed
,
Xenbase
Drews,
The nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal caps.
2011,
Pubmed
,
Xenbase
Dudziak,
Transcription factor HNF1beta and novel partners affect nephrogenesis.
2008,
Pubmed
,
Xenbase
Durbec,
GDNF signalling through the Ret receptor tyrosine kinase.
1996,
Pubmed
,
Xenbase
Ekblom,
In vitro segregation of the metanephric nephron.
1981,
Pubmed
Francipane,
Pluripotent Stem Cells to Rebuild a Kidney: The Lymph Node as a Possible Developmental Niche.
2016,
Pubmed
Haldin,
The lmx1b gene is pivotal in glomus development in Xenopus laevis.
2008,
Pubmed
,
Xenbase
Hawley,
Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction.
1995,
Pubmed
,
Xenbase
Heller,
Xenopus Pax-2/5/8 orthologues: novel insights into Pax gene evolution and identification of Pax-8 as the earliest marker for otic and pronephric cell lineages.
1999,
Pubmed
,
Xenbase
Heller,
Xenopus Pax-2 displays multiple splice forms during embryogenesis and pronephric kidney development.
1997,
Pubmed
,
Xenbase
Jones,
Xenopus: a prince among models for pronephric kidney development.
2005,
Pubmed
,
Xenbase
Karner,
Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis.
2009,
Pubmed
,
Xenbase
Keller,
How we are shaped: the biomechanics of gastrulation.
2003,
Pubmed
,
Xenbase
Keller,
The function and mechanism of convergent extension during gastrulation of Xenopus laevis.
1985,
Pubmed
,
Xenbase
Kim,
Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epithelia.
2005,
Pubmed
Kyuno,
A functional screen for genes involved in Xenopus pronephros development.
2008,
Pubmed
,
Xenbase
Kyuno,
GDNF expression during Xenopus development.
2007,
Pubmed
,
Xenbase
Lienkamp,
Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension.
2012,
Pubmed
,
Xenbase
Lienkamp,
Inversin relays Frizzled-8 signals to promote proximal pronephros development.
2010,
Pubmed
,
Xenbase
McCoy,
Non-canonical wnt signals antagonize and canonical wnt signals promote cell proliferation in early kidney development.
2011,
Pubmed
,
Xenbase
Miller,
Pronephric tubulogenesis requires Daam1-mediated planar cell polarity signaling.
2011,
Pubmed
,
Xenbase
Moody,
Fates of the blastomeres of the 32-cell-stage Xenopus embryo.
1987,
Pubmed
,
Xenbase
Moody,
Fates of the blastomeres of the 16-cell stage Xenopus embryo.
1987,
Pubmed
,
Xenbase
Moon,
Kidney diseases and tissue engineering.
2016,
Pubmed
Moriya,
Induction of Pronephric Tubules by Activin and Retinoic Acid in Presumptive Ectoderm of Xenopus laevis: (RA/kidney/mesoderm induction/Xenopus laevis).
1993,
Pubmed
,
Xenbase
Murugan,
WT1 and Sox11 regulate synergistically the promoter of the Wnt4 gene that encodes a critical signal for nephrogenesis.
2012,
Pubmed
,
Xenbase
Nakayama,
Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis.
2013,
Pubmed
,
Xenbase
Osafune,
In vitro induction of the pronephric duct in Xenopus explants.
2002,
Pubmed
,
Xenbase
Packard,
Luminal mitosis drives epithelial cell dispersal within the branching ureteric bud.
2013,
Pubmed
Pan,
A Cre-inducible fluorescent reporter for observing apical membrane dynamics.
2015,
Pubmed
Raciti,
Organization of the pronephric kidney revealed by large-scale gene expression mapping.
2008,
Pubmed
,
Xenbase
Rak-Raszewska,
Organ In Vitro Culture: What Have We Learned about Early Kidney Development?
2015,
Pubmed
Romagnani,
Renal progenitors: an evolutionary conserved strategy for kidney regeneration.
2013,
Pubmed
Saulnier,
Essential function of Wnt-4 for tubulogenesis in the Xenopus pronephric kidney.
2002,
Pubmed
,
Xenbase
Schmitt,
Engineering Xenopus embryos for phenotypic drug discovery screening.
2014,
Pubmed
,
Xenbase
Simons,
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways.
2005,
Pubmed
,
Xenbase
Srinivas,
Expression of green fluorescent protein in the ureteric bud of transgenic mice: a new tool for the analysis of ureteric bud morphogenesis.
1999,
Pubmed
Taelman,
The Notch-effector HRT1 gene plays a role in glomerular development and patterning of the Xenopus pronephros anlagen.
2006,
Pubmed
,
Xenbase
Taira,
Expression of the LIM class homeobox gene Xlim-1 in pronephros and CNS cell lineages of Xenopus embryos is affected by retinoic acid and exogastrulation.
1994,
Pubmed
,
Xenbase
Takasato,
Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis.
2015,
Pubmed
Tena,
Odd-skipped genes encode repressors that control kidney development.
2007,
Pubmed
,
Xenbase
Thesleff,
Role of transferrin in branching morphogenesis, growth and differentiation of the embryonic kidney.
1984,
Pubmed
Tomlinson,
Chemical genetics and drug discovery in Xenopus.
2012,
Pubmed
,
Xenbase
Uochi,
Sequential gene expression during pronephric tubule formation in vitro in Xenopus ectoderm.
1996,
Pubmed
,
Xenbase
Vize,
Model systems for the study of kidney development: use of the pronephros in the analysis of organ induction and patterning.
1997,
Pubmed
,
Xenbase
Vize,
Development of the Xenopus pronephric system.
1995,
Pubmed
,
Xenbase
Wang,
A novel Xenopus homologue of bone morphogenetic protein-7 (BMP-7).
1997,
Pubmed
,
Xenbase
Wang,
Targeted gene disruption in Xenopus laevis using CRISPR/Cas9.
2015,
Pubmed
,
Xenbase
Weber,
Regulation and function of the tissue-specific transcription factor HNF1 alpha (LFB1) during Xenopus development.
1996,
Pubmed
,
Xenbase
Wessely,
Xenopus pronephros development--past, present, and future.
2011,
Pubmed
,
Xenbase
Wild,
The mutated human gene encoding hepatocyte nuclear factor 1beta inhibits kidney formation in developing Xenopus embryos.
2000,
Pubmed
,
Xenbase
Wingert,
The zebrafish pronephros: a model to study nephron segmentation.
2008,
Pubmed
,
Xenbase
Zhou,
Proximo-distal specialization of epithelial transport processes within the Xenopus pronephric kidney tubules.
2004,
Pubmed
,
Xenbase
