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XB-ART-11414
Science 2000 Mar 03;2875458:1641-4. doi: 10.1126/science.287.5458.1641.
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A potassium channel protein encoded by chlorella virus PBCV-1.

Plugge B , Gazzarrini S , Nelson M , Cerana R , Van Etten JL , Derst C , DiFrancesco D , Moroni A , Thiel G .


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The large chlorella virus PBCV-1, which contains double-stranded DNA (dsDNA), encodes a 94-codon open reading frame (ORF) that contains a motif resembling the signature sequence of the pore domain of potassium channel proteins. Phylogenetic analyses of the encoded protein, Kcv, indicate a previously unidentified type of potassium channel. The messenger RNA encoded by the ORF leads to functional expression of a potassium-selective conductance in Xenopus laevis oocytes. The channel blockers amantadine and barium, but not cesium, inhibit this conductance, in addition to virus plaque formation. Thus, PBCV-1 encodes the first known viral protein that functions as a potassium-selective channel and is essential in the virus life cycle.

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